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p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells

  • Authors:
    • Jing‑Jing Guo
    • Hong‑Shun Xu
    • Gang Wu
    • Zhen‑Yu Ma
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of General Surgery, Renhe Hospital, Shanghai 200043, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4693-4696
    |
    Published online on: September 19, 2017
       https://doi.org/10.3892/etm.2017.5137
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Abstract

Thyroid cancer typically has a good prognosis; however, the risks of recurrence and chemoresistance associated with thyroid cancer remain a cause for concern. Papillary thyroid carcinoma (PTC) comprises 80% of all cases of thyroid carcinoma. A previous study reported that cluster of differentiation (CD) 44+/CD24‑ PTC cells may contribute to PTC recurrence and chemoresistance; however, the underlying molecular mechanisms remain elusive. In the present study, CD44+/CD24‑ cells were isolated from the TPC‑1 PTC cell line and biological function assays revealed that CD44+/CD24‑ cells were significantly more proliferative and chemoresistant compared with CD44‑/CD24‑ cells. Furthermore, the expression level of p63 was demonstrated to be negatively correlated with the expression of CD44 in PTC cells. The role of p63 in CD44+/CD24‑ cell proliferation and chemoresistance was investigated and, the ectopic expression of p63 was observed to significantly inhibit CD44+/CD24‑ cell proliferation and chemoresistance in vitro and in vivo. In conclusion, the present study indicated that CD44+/CD24‑ cells contribute to PTC proliferation and chemoresistance and that the suppression of p63 in CD44+/CD24‑ cells contributes to these effects.
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Copy and paste a formatted citation
Spandidos Publications style
Guo JJ, Xu HS, Wu G and Ma ZY: p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells. Exp Ther Med 14: 4693-4696, 2017.
APA
Guo, J., Xu, H., Wu, G., & Ma, Z. (2017). p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells. Experimental and Therapeutic Medicine, 14, 4693-4696. https://doi.org/10.3892/etm.2017.5137
MLA
Guo, J., Xu, H., Wu, G., Ma, Z."p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells". Experimental and Therapeutic Medicine 14.5 (2017): 4693-4696.
Chicago
Guo, J., Xu, H., Wu, G., Ma, Z."p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4693-4696. https://doi.org/10.3892/etm.2017.5137
Copy and paste a formatted citation
x
Spandidos Publications style
Guo JJ, Xu HS, Wu G and Ma ZY: p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells. Exp Ther Med 14: 4693-4696, 2017.
APA
Guo, J., Xu, H., Wu, G., & Ma, Z. (2017). p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells. Experimental and Therapeutic Medicine, 14, 4693-4696. https://doi.org/10.3892/etm.2017.5137
MLA
Guo, J., Xu, H., Wu, G., Ma, Z."p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells". Experimental and Therapeutic Medicine 14.5 (2017): 4693-4696.
Chicago
Guo, J., Xu, H., Wu, G., Ma, Z."p63 inhibits CD44+/CD24‑ cell proliferation and chemoresistance in papillary thyroid carcinoma cells". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4693-4696. https://doi.org/10.3892/etm.2017.5137
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