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Protein‑protein interaction analysis to identify biomarker networks for endometriosis

  • Authors:
    • Hong Xiao
    • Lihua Yang
    • Jianjun Liu
    • Yang Jiao
    • Lin Lu
    • Hongbo Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Gynecology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, Yunnan 650500, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4647-4654
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    Published online on: September 22, 2017
       https://doi.org/10.3892/etm.2017.5185
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Abstract

The identification of biomarkers and their interaction network involved in the processes of endometriosis is a critical step in understanding the underlying mechanisms of the disease. The aim of the present study was to construct biomarker networks of endometriosis that integrated human protein‑protein interactions and known disease‑causing genes. Endometriosis‑associated genes were extracted from Genotator and DisGeNet and biomarker network and pathway analyses were constructed using atBioNet. Of 100 input genes, 96 were strongly mapped to six major modules. The majority of the pathways in the first module were associated with the proliferation of cancer cells, the enriched pathways in module B were associated with the immune system and infectious diseases, module C included pathways related to immune and metastasis, the enriched pathways in module D were associated with inflammatory processes, and the majority of the pathways in module E were related to replication and repair. The present approach identified known and potential biomarkers in endometriosis. The identified biomarker networks are highly enriched in biological pathways associated with endometriosis, which may provide further insight into the molecular mechanisms underlying endometriosis.
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1 

Podgaec S, Abrao MS, Dias JA Jr, Rizzo LV, de Oliveira RM and Baracat EC: Endometriosis: An inflammatory disease with a Th2 immune response component. Hum Reprod. 22:1373–1379. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Braun DP and Dmowski WP: Endometriosis: Abnormal endometrium and dysfunctional immune response. Curr Opin Obstet Gynecol. 10:365–369. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Sha G, Wu D, Zhang L, Chen X, Lei M, Sun H, Lin S and Lang J: Differentially expressed genes in human endometrial endothelial cells derived from eutopic endometrium of patients with endometriosis compared with those from patients without endometriosis. Hum Reprod. 22:3159–3169. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Kato N, Sasou S and Motoyama T: Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary. Mod Pathol. 19:83–89. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Kvaskoff M, Mu F, Terry KL, Harris HR, Poole EM, Farland L and Missmer SA: Endometriosis: A high-risk population for major chronic diseases? Hum Reprod Update. 21:500–516. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Ahn SH, Monsanto SP, Miller C, Singh SS, Thomas R and Tayade C: Pathophysiology and immune dysfunction in endometriosis. Biomed Res Int. 2015:7959762015. View Article : Google Scholar : PubMed/NCBI

7 

Hamosh A, Scott AF, Amberger JS, Bocchini CA and McKusick VA: Online mendelian inheritance in man (OMIM), a knowledgebase of human genes and genetic disorders. Nucleic Acids Res. 33(Database issue): D514–D517. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Stenson PD, Mort M, Ball EV, Howells K, Phillips AD, Thomas NS and Cooper DN: The human gene mutation database: 2008 pdate. Genome Med. 1:132009. View Article : Google Scholar : PubMed/NCBI

9 

Becker KG, Barnes KC, Bright TJ and Wang SA: The genetic association database. Nature Genet. 36:431–432. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Wall DP, Pivovarov R, Tong M, Jung JY, Fusaro VA, DeLuca TF and Tonellato PJ: Genotator: A disease-agnostic tool for genetic annotation of disease. BMC Med Genomics. 3:502010. View Article : Google Scholar : PubMed/NCBI

11 

Bauer-Mehren A, Rautschka M, Sanz F and Furlong LI: DisGeNET: A Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks. Bioinformatics. 26:2924–2926. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, et al: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 125:801–814. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, et al: Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 39:1338–1349. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Jia P, Kao CF, Kuo PH and Zhao Z: A comprehensive network and pathway analysis of candidate genes in major depressive disorder. BMC Syst Biol. 5 Suppl 3:S122011. View Article : Google Scholar : PubMed/NCBI

15 

Vidal M, Cusick ME and Barabási AL: Interactome networks and human disease. Cell. 144:986–998. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Wu G, Feng X and Stein L: A human functional protein interaction network and its application to cancer data analysis. Genome Biol. 11:R532010. View Article : Google Scholar : PubMed/NCBI

17 

Schadt EE: Molecular networks as sensors and drivers of common human diseases. Nature. 461:218–223. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Ding Y, Chen M, Liu Z, Ding D, Ye Y, Zhang M, Kelly R, Guo L, Su Z, Harris SC, et al: atBioNet-an integrated network analysis tool for genomics and biomarker discovery. BMC Genomics. 13:3252012. View Article : Google Scholar : PubMed/NCBI

19 

Stark C, Breitkreutz BJ, Chatr-Aryamontri A and Tyers M: The BioGRID Interaction Database: 2011 pdate. Nucleic Acids Res. 39(Database issue): D698–D704. 2010.PubMed/NCBI

20 

Xenarios I, Rice DW, Salwinski L, Baron MK, Marcotte EM and Eisenberg D: DIP: The database of interacting proteins. Nucleic Acids Res. 28:289–291. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Prasad TS Keshava, Goel R, Kandasamy K, Keerthikumar S, Kumar S, Mathivanan S, Telikicherla D, Raju R, Shafreen B, Venugopal A, et al: Human protein reference database-2009 update. Nucleic Acids Res. 37(Database issue): D767–D772. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Aranda B, Achuthan P, Alam-Faruque Y, Armean I, Bridge A, Derow C, Feuermann M, Ghanbarian AT, Kerrien S, Khadake J, et al: The IntAct molecular interaction database in 2010. Nucleic Acids Res. 38(Database issue): D525–D531. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Licata L, Briganti L, Peluso D, Perfetto L, Iannuccelli M, Galeota E, Sacco F, Palma A, Nardozza AP, Santonico E, et al: MINT, the molecular interaction database: 2012 pdate. Nucleic Acids Res. 40(Database issue): D857–D861. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Matthews L, Gopinath G, Gillespie M, Caudy M, Croft D, de Bono B, Garapati P, Hemish J, Hermjakob H, Jassal B, et al: Reactome knowledgebase of human biological pathways and processes. Nucleic Acids Res. 37(Database issue): D619–D622. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R, et al: SPIKE-a database, visualization and analysis tool of cellular signaling pathways. BMC bioinformatics. 9:1102008. View Article : Google Scholar : PubMed/NCBI

26 

Xu X, Yuruk N, Feng Z and Schweiger T: SCAN: A structural clustering algorithm for networks. Proceedings of the 13th ACM SIGKDD international conference on Knowledge Discovery and Data Mining. ACM. San Jose, CA. pp. 824–833. 2007;

27 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Hwang JH, Oh JJ, Wang T, Jin YC, Lee JS, Choi JR, Lee KS, Joo JK and Lee HG: Identification of biomarkers for endometriosis in eutopic endometrial cells from patients with endometriosis using a proteomics approach. Mol Med Rep. 8:183–188. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Wei WD, Ruan F, Tu FX, Zhou CY and Lin J: Expression of suppressor of cytokine signaling-3 and caspase-3 in endometriosis and their correlation. Zhonghua Bing Li Xue Za Zhi. 42:515–518. 2013.(In Chinese). PubMed/NCBI

30 

Hayrabedyan S, Kyurkchiev S and Kehayov I: Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis. Reprod Biol. 5:51–67. 2005.PubMed/NCBI

31 

Hou Z, Zhou J, Ma X, Fan L, Liao L and Liu J: Role of interleukin-1 receptor type II in the pathogenesis of endometriosis. Fertil Steril. 89:42–51. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Selam B, Kayisli UA, Garcia-Velasco JA and Arici A: Extracellular matrix-dependent regulation of Fas ligand expression in human endometrial stromal cells. Biol Reprod. 66:1–5. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Osteen KG, Yeaman GR and Bruner-Tran KL: Matrix metalloproteinases and endometriosis. Semin Reprod Med. 21:155–164. 2003. View Article : Google Scholar : PubMed/NCBI

34 

de Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, et al: A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet. 38:1166–1172. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Kumar H, Kawai T and Akira S: Toll-like receptors and innate immunity. Biochem Biophys Res Commun. 388:621–625. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Hsieh YY, Chang CC, Chen SY, Chen CP, Lin WH and Tsai FJ: XRCC1 399 Arg-related genotype and allele, but not XRCC1 His107Arg, XRCC1 Trp194Arg, KCNQ2, AT1R and hOGG1 polymorphisms, are associated with higher susceptibility of endometriosis. Gynecol Endocrinol. 28:305–309. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Jiang QY and Wu RJ: Growth mechanisms of endometriotic cells in implanted places: A review. Gynecol Endocrinol. 28:562–567. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Vlahos NF, Economopoulos KP and Fotiou S: Endometriosis, in vitro fertilisation and the risk of gynaecological malignancies, including ovarian and breast cancer. Best Pract Res Clin Obstet Gynaecol. 24:39–50. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Pollacco J, Sacco K, Portelli M, Schembri-Wismayer P and Calleja-Agius J: Molecular links between endometriosis and cancer. Gynecol Endocrinol. 28:577–581. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Jiang X, Hitchcock A, Bryan EJ, Watson RH, Englefield P, Thomas EJ and Campbell IG: Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian tumor suppressor gene loci. Cancer Res. 56:3534–3539. 1996.PubMed/NCBI

41 

Hsieh YY, Chang CC, Tsai FJ, Hsu CM, Lin CC and Tsai CH: Interleukin-2 receptor beta (IL-2R beta)-627*C homozygote but not IL-12R beta 1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis. Fertil Steril. 84:510–512. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Ayaz L, Celik SK, Cayan F, Aras-Ates N and Tamer L: Functional association of interleukin-18 gene −607 C/A promoter polymorphisms with endometriosis. Fertil Steril. 95:298–300. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Monsanto SP, Edwards AK, Zhou J, Nagarkatti P, Nagarkatti M, Young SL, Lessey BA and Tayade C: Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients. Fertil Steril. 105:968–977. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Harada T, Iwabe T and Terakawa N: Role of cytokines in endometriosis. Fertil Steril. 76:1–10. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Shuai K and Liu B: Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 3:900–911. 2003. View Article : Google Scholar : PubMed/NCBI

46 

Petrilli V, Dostert C, Muruve DA and Tschopp J: The inflammasome: A danger sensing complex triggering innate immunity. Curr Opin Immunol. 19:615–622. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Harada M, Osuga Y, Hirata T, Hirota Y, Koga K, Yoshino O, Morimoto C, Fujiwara T, Momoeda M, Yano T, et al: Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis. Hum Reprod. 19:2188–2191. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Nissinen L and Kähäri VM: Matrix metalloproteinases in inflammation. Biochim Biophys Acta. 1840:2571–2580. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Cominelli A, Chevronnay HP Gaide, Lemoine P, Courtoy PJ, Marbaix E and Henriet P: Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions. Mol Hum Reprod. 20:767–775. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Nagase H, Visse R and Murphy G: Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res. 69:562–573. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Mu L, Zheng W, Wang L, Chen XJ, Zhang X and Yang JH: Alteration of focal adhesion kinase expression in eutopic endometrium of women with endometriosis. Fertil Steril. 89:529–537. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Celik O, Hascalik S, Elter K, Tagluk ME, Gurates B and Aydin NE: Combating endometriosis by blocking proteasome and nuclear factor-kappaB pathways. Hum Reprod. 23:2458–2465. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Nothnick WB: Treating endometriosis as an autoimmune disease. Fertil Steril. 76:223–231. 2001. View Article : Google Scholar : PubMed/NCBI

54 

Kitawaki J, Obayashi H, Kado N, Ishihara H, Koshiba H, Maruya E, Saji H, Ohta M, Hasegawa G, Nakamura N, et al: Association of HLA class I and class II alleles with susceptibility to endometriosis. Hum Immunol. 63:D1033–D1038. 2002. View Article : Google Scholar

55 

Zhang X, Sharma RK, Agarwal A and Falcone T: Effect of pentoxifylline in reducing oxidative stress-induced embryotoxicity. J Assist Reprod Genet. 22:415–417. 2005. View Article : Google Scholar : PubMed/NCBI

56 

Wood RD, Mitchell M, Sgouros J and Lindahl T: Human DNA repair genes. Science. 291:1284–1289. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Hsu CM, Chang WS, Hwang JJ, Wang JY, Hsiao YL, Tsai CW, Liu JC, Ying TH and Bau DT: The role of apurinic/apyrimidinic endonuclease DNA repair gene in endometriosis. Cancer Genomics Proteomics. 11:295–301. 2014.PubMed/NCBI

58 

Brem R and Hall J: XRCC1 is required for DNA single-strand break repair in human cells. Nucleic Acids Res. 33:2512–2520. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xiao H, Yang L, Liu J, Jiao Y, Lu L and Zhao H: Protein‑protein interaction analysis to identify biomarker networks for endometriosis. Exp Ther Med 14: 4647-4654, 2017.
APA
Xiao, H., Yang, L., Liu, J., Jiao, Y., Lu, L., & Zhao, H. (2017). Protein‑protein interaction analysis to identify biomarker networks for endometriosis. Experimental and Therapeutic Medicine, 14, 4647-4654. https://doi.org/10.3892/etm.2017.5185
MLA
Xiao, H., Yang, L., Liu, J., Jiao, Y., Lu, L., Zhao, H."Protein‑protein interaction analysis to identify biomarker networks for endometriosis". Experimental and Therapeutic Medicine 14.5 (2017): 4647-4654.
Chicago
Xiao, H., Yang, L., Liu, J., Jiao, Y., Lu, L., Zhao, H."Protein‑protein interaction analysis to identify biomarker networks for endometriosis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4647-4654. https://doi.org/10.3892/etm.2017.5185
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao H, Yang L, Liu J, Jiao Y, Lu L and Zhao H: Protein‑protein interaction analysis to identify biomarker networks for endometriosis. Exp Ther Med 14: 4647-4654, 2017.
APA
Xiao, H., Yang, L., Liu, J., Jiao, Y., Lu, L., & Zhao, H. (2017). Protein‑protein interaction analysis to identify biomarker networks for endometriosis. Experimental and Therapeutic Medicine, 14, 4647-4654. https://doi.org/10.3892/etm.2017.5185
MLA
Xiao, H., Yang, L., Liu, J., Jiao, Y., Lu, L., Zhao, H."Protein‑protein interaction analysis to identify biomarker networks for endometriosis". Experimental and Therapeutic Medicine 14.5 (2017): 4647-4654.
Chicago
Xiao, H., Yang, L., Liu, J., Jiao, Y., Lu, L., Zhao, H."Protein‑protein interaction analysis to identify biomarker networks for endometriosis". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4647-4654. https://doi.org/10.3892/etm.2017.5185
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