Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2017 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins

  • Authors:
    • Wenwen Gao
    • Wangdi Wang
    • Wenjian Sun
    • Mingfang Wang
    • Na Zhang
    • Shuwen Yu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Pharmacy, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4627-4632
    |
    Published online on: September 22, 2017
       https://doi.org/10.3892/etm.2017.5191
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to compare the antitumor efficiency of Phellinus igniarius polysaccharides (PIP) from six different origins and preliminarily investigate its potential mechanisms. PIP was extracted using the microwave extraction method. The corresponding in vivo antitumor efficacy was assessed in Kunming mice bearing H22 tumors and Gansu PIP (GPIP) was identified to have a significantly higher antitumor efficacy compared with the control group (P<0.05), while no significant difference was observed following treatment with PIP from different origins (P>0.05). The spleen index of the GPIP group significantly increased compared with the saline and CTX groups (P<0.01). The in vitro MTT assay of GPIP on HepG2 cells indicated that GPIP had no direct cytotoxicity. The serum immune cytokines of interleukin‑2, interleukin‑12 and interferon‑γ were assessed using the ELISA method. The concentration of all three serum cytokines significantly increased compared with saline and CTX groups (P<0.01) indicating that activating the immune system may be a potential antitumor mechanism. These results demonstrated that GPIP has great potential as a natural antitumor agent with immunomodulatory activity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sliva D, Jedinak A, Kawasaki J, Harvey K and Slivova V: Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling. Br J Cancer. 98:1348–1356. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Chen Y, Wan Y, Wang Y, Zhang H and Jiao Z: Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles. Int J Nanomedicine. 6:2321–2326. 2011.PubMed/NCBI

3 

Sun Y, Sun T, Wang F, Zhang J, Li C, Chen X, Li Q and Sun S: A polysaccharide from the fungi of Huaier exhibits anti-tumor potential and immunomodulatory effects. Carbohydr Polym. 92:577–582. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yi Y, Zhang MW, Liao ST, Zhang RF, Deng YY, Wei ZC, Tang XJ and Zhang Y: Structural features and immunomodulatory activities of polysaccharides of longan pulp. Carbohydr Polym. 87:636–643. 2012. View Article : Google Scholar

5 

Fabricant DS and Farnsworth NR: The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 109 Suppl. 1:S69–S75. 2001. View Article : Google Scholar

6 

Gao C, Zhong L, Jiang L, Geng C, Yao X and Cao J: Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells. Phytomedicine. 20:705–709. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Zhao R, Gao X, Cai Y, Shao X, Jia G, Huang Y, Qin X, Wang J and Zheng X: Antitumor activity of Portulaca oleracea L. polysaccharides against cervical carcinoma in vitro and in vivo. Carbohydr Polym. 96:376–383. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Zou X, Sun M and Guo X: Quantitative response of cell growth and polysaccharide biosynthesis by the medicinal mushroom Phellinus linteus to NaCl in the medium. World J Microb Biot. 22:1129–1133. 2006. View Article : Google Scholar

9 

Li X, Jiao LL, Zhang X, Tian WM, Chen S and Zhang LP: Anti-tumor and immunomodulating activities of proteoglycans from mycelium of Phellinus nigricans and culture medium. Int Immunopharmacol. 8:909–915. 2008. View Article : Google Scholar : PubMed/NCBI

10 

He P, Geng L, Wang J, Wang Z, Mao D and Xu C: Purification, characterization and bioactivity of an extracellular polysaccharide produced from Phellinus igniarius. Ann Microbiol. 62:1697–1707. 2012. View Article : Google Scholar

11 

Li YG, Ji DF, Zhong S, Liu PG, Lv ZQ, Zhu JX, Chen JE and Chen HP: Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway. J Ethnopharmacol. 150:187–195. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zhong S, Ji DF, Li YG, Lin TB, Lv ZQ and Chen HP: Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells. Chem Biol Interact. 206:222–229. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Zong A, Cao H and Wang F: Anticancer polysaccharides from natural resources: A review of recent research. Carbohydr Polym. 90:1395–1410. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Wu SJ, Liaw CC, Pan SZ, Yang HC and Ng LT: Phellinus linteus polysaccharides and their immunomodulatory properties in human monocytic cells. J Funct Foods. 5:679–683. 2013. View Article : Google Scholar

15 

Blattman JN and Greenberg PD: Cancer immunotherapy: A treatment for the masses. Science. 305:200–205. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Gajewski TF, Woo SR, Zha Y, Spaapen R, Zheng Y, Corrales L and Spranger S: Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment. Curr Opin Immunol. 25:268–276. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Landskron G, De la Fuente M, Thuwajit P, Thuwajit C and Hermoso MA: Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. 2014:1491852014. View Article : Google Scholar : PubMed/NCBI

18 

Li Xiong S, Li A, Huang N, Lu F and Hou D: Antioxidant and immunoregulatory activity of different polysaccharide fractions from tuber of Ophiopogon japonicus. Carbohydr Polym. 86:1273–1280. 2011. View Article : Google Scholar

19 

Jeff IB, Yuan X, Sun L, Kassim RM, Foday AD and Zhou Y: Purification and in vitro anti-proliferative effect of novel neutral polysaccharides from Lentinus edodes. Int J Biol Macromol. 52:99–106. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Mou ZZ, Wang MF, Gao WW, Zhang N and Yu SW: Extraction of Phellinus igniarius polysaccharides and composition analysis of monosaccharide. Chin J Experimental Traditional Medical Formulae. 20:13–15. 2014.(In Chinese).

21 

Chen L, Pan J, Li X, Zhou Y, Meng Q and Wang Q: Endo-polysaccharide of Phellinus igniarius exhibited anti-tumor effect through enhancement of cell mediated immunity. Int Immunopharmacol. 11:255–259. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Huang HY, Chieh SY, Tso TK, Chien TY, Lin HT and Tsai YC: Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice. J Ethnopharmacol. 133:460–466. 2011. View Article : Google Scholar : PubMed/NCBI

23 

De Silva DD, Rapior S, Fons F, Bahkali AH and Hyde KD: Medicinal mushrooms in supportive cancer therapies: An approach to anti-cancer effects and putative mechanisms of action. Fungal Diversity. 55:1–35. 2012. View Article : Google Scholar

24 

Wong KH, Lai CK and Cheung PC: Immunomodulatory activities of mushroom sclerotial polysaccharides. Food Hydrocolloids. 25:150–158. 2011. View Article : Google Scholar

25 

Xie G, Schepetkin IA and Quinn MT: Immunomodulatory activity of acidic polysaccharides isolated from Tanacetum vulgare L. Int Immunopharmacol. 7:1639–1650. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A and Alber G: Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 184:747–752. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Qin Z and Blankenstein T: CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity. 12:677–686. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao W, Wang W, Sun W, Wang M, Zhang N and Yu S: Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins. Exp Ther Med 14: 4627-4632, 2017.
APA
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., & Yu, S. (2017). Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins. Experimental and Therapeutic Medicine, 14, 4627-4632. https://doi.org/10.3892/etm.2017.5191
MLA
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., Yu, S."Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins". Experimental and Therapeutic Medicine 14.5 (2017): 4627-4632.
Chicago
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., Yu, S."Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4627-4632. https://doi.org/10.3892/etm.2017.5191
Copy and paste a formatted citation
x
Spandidos Publications style
Gao W, Wang W, Sun W, Wang M, Zhang N and Yu S: Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins. Exp Ther Med 14: 4627-4632, 2017.
APA
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., & Yu, S. (2017). Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins. Experimental and Therapeutic Medicine, 14, 4627-4632. https://doi.org/10.3892/etm.2017.5191
MLA
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., Yu, S."Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins". Experimental and Therapeutic Medicine 14.5 (2017): 4627-4632.
Chicago
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., Yu, S."Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4627-4632. https://doi.org/10.3892/etm.2017.5191
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team