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Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats

  • Authors:
    • Hancheng Li
    • Chan Li
    • Yuting Zhou
    • Chaohua Luo
    • Jingying Ou
    • Jing Li
    • Zhixian Mo
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3369-3375
    |
    Published online on: January 30, 2018
       https://doi.org/10.3892/etm.2018.5814
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Abstract

Drug abuse is a public health and social problem. A number of studies have reported that drug addiction is associated with microRNAs (miRNAs). By comparing the expression of miRNAs in the serum exosomes of methamphetamine‑dependent and ketamine‑dependent rats, the aim of the present study was to provide insights into the miRNA‑mediated associations between the two groups. Published results on conditioned place preference (CPP) in rats conditioned by methamphetamine and ketamine were replicated. The expression of miRNAs in serum exosomes were determined by gene‑chip sequencing. The potential target genes of differentially expressed (DE) co‑miRNAs were predicted in the methamphetamine and ketamine rats, then functional analysis of their target genes was performed. Methamphetamine and ketamine reward greatly increased the activity time and distance in the intrinsically non‑preferred side of the behavioral apparatus when compared with controlled rats (P<0.01). In addition, methamphetamine upregulated the expression of 276 miRNAs and downregulated 25 miRNAs, while ketamine only downregulated the expression of 267 miRNAs. Ten DE co‑miRNAs in the two model groups were identified. Functional analysis revealed that DE co‑miRNAs are involved in the development of addiction at different stages, and their target genes were enriched in ‘vesicular transport’, ‘amphetamine addiction’, ‘dopaminergic synapse’ and ‘GABAergic synapse’. Therefore, it was suggested that these co‑miRNAs may have a strong association with drug addiction, and they may be involved in the different addiction processes, which partly explains methamphetamine and ketamine addiction.
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1 

Tomás-Rosselló J, Rawson RA, Zarza MJ, Bellows A, Busse A, Saenz E, Freese T, Shawkey M, Carise D, Ali R and Ling W: United nations office on drugs and crime international network of drug dependence treatment and rehabilitation resource centres: Treatnet. Subst Abus. 31:251–263. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Vinogradova MV, Kryukova EM, Kulyamina OS, Vapnyarskaya OI and Sokolova AP: Approaches to the study of the status and trends of drug abuse, rehabilitation and reintegration of drug users. Biosci Biotechnol Res Asia. 11:1505–1514. 2014. View Article : Google Scholar

3 

Baptista S, Lourenço J, Milhazes N, Borges F, Silva AP and Bacci A: Long-term treatment with low doses of methamphetamine promotes neuronal differentiation and strengthens long-term potentiation of glutamatergic synapses onto dentate granule neurons. eNeuro. 3:pii: ENEURO2016. View Article : Google Scholar

4 

Stoicea N, Versteeg G, Florescu D, Joseph N, Fiorda-Diaz J, Navarrete V and Bergese SD: Ketamine-based anesthetic protocols and evoked potential monitoring: A risk/benefit overview. Front Neurosci. 10:372016. View Article : Google Scholar : PubMed/NCBI

5 

Tzschentke TM: Measuring reward with the conditioned place preference (CPP) paradigm: Update of the last decade. Addict Biol. 12:227–462. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Tzschentke TM: Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol. 56:613–672. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Sun W: Dopamine neurons in the ventral tegmental area: Drug-induced synaptic plasticity and its role in relapse to drug-seeking behavior. Curr Drug Abuse Rev. 4:270–285. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, Willoughby D, Wahlestedt C, Conkright MD and Kenny PJ: Striatal microRNA controls cocaine intake through CREB signalling. Nature. 466:197–202. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Maccani MA, Avissar-Whiting M, Banister CE, McGonnigal B, Padbury JF and Marsit CJ: Maternal cigarette smoking during pregnancy is associated with downregulation of mir-16, mir-21, and mir-146a in the placenta. Epigenetics. 5:583–589. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Zheng H, Zeng Y, Zhang X, Chu J, Loh HH and Law PY: mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD. Mol Pharmacol. 77:102–109. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Baek MN, Jung KH, Halder D, Choi MR, Lee BH, Lee BC, Jung MH, Choi IG, Chung MK, Oh DY and Chai YG: Artificial microRNA-based neurokinin-1 receptor gene silencing reduces alcohol consumption in mice. Neurosci Lett. 475:124–128. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, Stefanis L and Vekrellis K: Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci. 30:6838–6851. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Simons M and Raposo G: Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol. 21:575–581. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lai R, Yeo R, Tan S, Zhang B, Yin Y, Sze N, Choo A and Lim S: Biochemical potential of MSC exosome. Cytotherap. 16:S432014. View Article : Google Scholar

15 

Sahoo S, Klychko E, Thorne T, Misener S, Schultz KM, Millay M, Ito A, Liu T, Kamide C, Agrawal H, et al: Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res. 109:724–728. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Wang HW, Wang J, Ding F, Callahan K, Bratkowski MA, Butler JS, Nogales E and Ke A: Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3′ end processing. Proc Natl Acad Sci USA. 104:pp. 16844–16849. 2007; View Article : Google Scholar : PubMed/NCBI

17 

Liu W, Peng QX, Lin XL, Luo CH, Jiang MJ, Mo ZX and Yung KK: Effect of rhynchophylline on the expression of p-CREB and sc-Fos in triatum and hippocampal CA1 area of methamphetamine-induced conditioned place preference rats. Fitoterapia. 92:16–22. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Li J, Liu W, Peng Q, Jiang M, Luo C, Guo Y, Liu Y, Fang M and Mo Z: Effect of rhynchophylline on conditioned place preference on expression of NR2B in methamphetamine-dependent mice. Biochem Biophys Res Commun. 452:695–700. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Robinson MD, McCarthy DJ and Smyth GK: EdgeR: A bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Manzanedo C, Aguilar MA, Rodriguez-Arias M and Miñarro J: Conditioned place preference paradigm can be a mouse model of relapse to opiates. Neurosci Res Commun. 28:23–29. 2001. View Article : Google Scholar

21 

Van den Oever MC, Spijker S and Smit AB: The synaptic pathology of drug addiction. Adv Exp Med Biol. 970:469–491. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Gonda DD, Akers JC, Kim R, Kalkanis SN, Hochberg FH, Chen CC and Carter BS: Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles. Neurosurgery. 72:501–510. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yang MH, Jung MS, Lee MJ, Yoo KH, Yook YJ, Park EY, Choi SH, Suh YJ, Kim KW and Park JH: Gene expression profiling of the rewarding effect caused by methamphetamine in the mesolimbic dopamine system. Mol Cells. 26:121–130. 2008.PubMed/NCBI

24 

During MJ, Bean AJ and Roth RH: Effects of CNS stimulants on the in vivo release of the colocalized transmitters, dopamine and neurotensin, from rat prefrontal cortex. Neurosci Lett. 140:129–133. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Vaz GC, Bahia AP, de Figueiredo Müller-Ribeiro FC, Xavier CH, Patel KP, Santos RA, Moreira FA, Frézard F and Fontes MA: Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system. Neuroscience. 285:60–69. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Nugent FS: VTA GABAergic plasticity: An inhibitory synaptic model of drug addiction. Springer; New York, NY: 2011

27 

Borner GH, Antrobus R, Hirst J, Bhumbra GS, Kozik P, Jackson LP, Sahlender DA and Robinson MS: Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. J Cell Biol. 197:141–160. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Bauer MC, O'Connell DJ, Maj M, Wagner L, Cahill DJ and Linse S: Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion. Mol Biosyst. 7:2196–2204. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Byrne FL, Poon IK, Modesitt SC, Tomsig JL, Chow JD, Healy ME, Baker WD, Atkins KA, Lancaster JM, Marchion DC, et al: Metabolic vulnerabilities in endometrial cancer. Cancer Res. 74:5832–5845. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Surhone LM, Tennoe MT and Henssonow SF: Tnfrsf1b. Betascript Publishing; 2011

31 

Pati D, Zhang N and Plon SE: Linking sister chromatid cohesion and apoptosis: Role of Rad21. Mol Cell Biol. 22:8267–8277. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Li C, Zhou Y, Luo C, Ou J, Li J and Mo Z: Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats. Exp Ther Med 15: 3369-3375, 2018.
APA
Li, H., Li, C., Zhou, Y., Luo, C., Ou, J., Li, J., & Mo, Z. (2018). Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats. Experimental and Therapeutic Medicine, 15, 3369-3375. https://doi.org/10.3892/etm.2018.5814
MLA
Li, H., Li, C., Zhou, Y., Luo, C., Ou, J., Li, J., Mo, Z."Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats". Experimental and Therapeutic Medicine 15.4 (2018): 3369-3375.
Chicago
Li, H., Li, C., Zhou, Y., Luo, C., Ou, J., Li, J., Mo, Z."Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3369-3375. https://doi.org/10.3892/etm.2018.5814
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Li C, Zhou Y, Luo C, Ou J, Li J and Mo Z: Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats. Exp Ther Med 15: 3369-3375, 2018.
APA
Li, H., Li, C., Zhou, Y., Luo, C., Ou, J., Li, J., & Mo, Z. (2018). Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats. Experimental and Therapeutic Medicine, 15, 3369-3375. https://doi.org/10.3892/etm.2018.5814
MLA
Li, H., Li, C., Zhou, Y., Luo, C., Ou, J., Li, J., Mo, Z."Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats". Experimental and Therapeutic Medicine 15.4 (2018): 3369-3375.
Chicago
Li, H., Li, C., Zhou, Y., Luo, C., Ou, J., Li, J., Mo, Z."Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3369-3375. https://doi.org/10.3892/etm.2018.5814
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