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Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology

  • Authors:
    • Yujen Tseng
    • Lili Ma
    • Tiancheng Luo
    • Xiaoqing Zeng
    • Na Li
    • Yichao Wei
    • Ji Zhou
    • Feng Li
    • Shiyao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Endoscopy, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Gastroenterology, Endoscopy Center, Evidence‑Based Medicine Center, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China
    Copyright: © Tseng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3329-3335
    |
    Published online on: January 30, 2018
       https://doi.org/10.3892/etm.2018.5816
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Abstract

Portal hypertension secondary to liver cirrhosis may cause a number of life-threatening complications. The rupture of gastroesophageal varices is associated with a high mortality rate of 15‑30%. Hepatic venous pressure gradient (HVPG) is an accurate reflection of disease severity, however this can only be assessed via an invasive interventional procedure. The aim of the present study was to explore a non-invasive method based on 3D computed tomography (CT) volume rendering technology to accurately predict HVPG. A total of 77 patients diagnosed with liver cirrhosis underwent HVPG examination in the present study and the appropriate clinical and radiological data were retrospectively reviewed. A 3D liver and spleen volume rendering was constructed for volume measurements. All non-invasive parameters were tested using univariate analysis and the resulting variables that were statistically significant (P<0.20) were used in the multivariate linear regression model. The HVPG predictive model was as follows: HVPG = 18.726 ‑ 0.324 (albumin) + 1.57 (amino­transferase-to-platelet ratio index) + 0.004 (liver volume) (multivariate regression analysis, P=0.006). The corresponding area under receiver operating characteristic curve to identify clinically significant portal hypertension defined as HVPG ≥10 mmHg was 0.810 (95% confidence interval; 0.705‑0.891), with an optimal cut‑off value of 12.84, yielding a sensitivity of 80.36% a specificity of 76.19%. The results of the present study indicate that 3D CT volume rendering technology may have the potential to be used for non-invasive prediction of HVPG.
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1 

Mokdad AA, Lopez AD, Shahraz S, Lozano R, Mokdad AH, Stanaway J, Murray CJ and Naghavi M: Liver cirrhosis mortality in 187 countries between 1980 and 2010: A systematic analysis. BMC Med. 12:1452014. View Article : Google Scholar : PubMed/NCBI

2 

Triantos CK, Nikolopoulou V and Burroughs AK: Review article: The therapeutic and prognostic benefit of portal pressure reduction in cirrhosis. Aliment Pharmacol Ther. 28:943–952. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Garcia-Tsao G, Sanyal AJ, Grace ND and Carey W; Practice Guidelines Committee of the American Association for the Study of Liver Diseases, ; Practice Parameters Committee of the American College of Gastroenterology, : Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 46:922–938. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Garcia-Tsao G and Bosch J: Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med. 362:823–832. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Procopet B, Cristea VM, Robic MA, Grigorescu M, Agachi PS, Metivier S, Peron JM, Selves J, Stefanescu H, Berzigotti A, et al: Serum tests, liver stiffness and artificial neural networks for diagnosing cirrhosis and portal hypertension. Dig Liver Dis. 47:411–416. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Suk KT: Hepatic venous pressure gradient: Clinical use in chronic liver disease. Clin Mol Hepatol. 20:6–14. 2014. View Article : Google Scholar : PubMed/NCBI

7 

de Franchis R: Baveno VI Faculty: Expanding consensus in portal hypertension: Report of the Baveno VI consensus workshop: Stratifying risk and individualizing care for portal hypertension. J Hepatol. 63:743–752. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Procopet B, Berzigotti A, Abraldes JG, Turon F, Hernandez-Gea V, Garcia-Pagan JC and Bosch J: Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension. J Hepatol. 62:1068–1075. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Merkel C and Montagnese S: Should we routinely measure portal pressure in patients with cirrhosis, using hepatic venous pressure gradient (HVPG) as guidance for prophylaxis and treatment of bleeding and re-bleeding? Yes! Eur J Intern Med. 22:1–4. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K and Blei AT: Hepatic encephalopathy-definition, nomenclature, diagnosis and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 35:716–721. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Bedossa P and Poynard T: An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 24:289–293. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Sarin SK, Lahoti D, Saxena SP, Murthy NS and Makwana UK: Prevalence, classification and natural history of gastric varices: A long-term follow-up study in 568 portal hypertension patients. Hepatology. 16:1343–1349. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Sarin SK and Lahoti D: Management of gastric varices. Baillieres Clin Gastroenterol. 6:527–548. 1992. View Article : Google Scholar : PubMed/NCBI

14 

Cholongitas E, Papatheodoridis GV, Vangeli M, Terreni N, Patch D and Burroughs AK: Systematic review: The model for end-stage liver disease-should it replace Child-Pugh's classification for assessing prognosis in cirrhosis? Aliment Pharmacol Ther. 22:1079–1089. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Sarin SK and Kumar A: Endoscopic treatment of gastric varices. Clin Liver Dis. 18:809–827. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sarin SK: Injection sclerotherapy for varices. Trop Gastroenterol. 8:177–181. 1987.PubMed/NCBI

17 

Saad WE: Balloon-occluded retrograde transvenous obliteration of gastric varices: Concept, basic techniques, and outcomes. Semin Intervent Radiol. 29:118–128. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Garcia-Pagán JC, Barrufet M, Cardenas A and Escorsell À: Management of gastric varices. Clin Gastroenterol Hepatol. 12:919–928. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Kim I, Jang YJ, Ryeom H, Lee SM, Lee HJ, Kim GC and Kim HJ: Variation in hepatic segmental volume distribution according to different causes of liver cirrhosis: CT volumetric evaluation. J Comput Assist Tomogr. 36:220–225. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Yan S, Wu H, Wang G, Chen Y, Zhang C and Zhu Q: A new model combining the liver/spleen volume ratio and classification of varices predicts HVPG in hepatitis B patients with cirrhosis. Eur J Gastroen Hepat. 27:335–343. 2015. View Article : Google Scholar

21 

de Franchis R: Baveno V Faculty: Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 53:762–768. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Kim TY, Jeong WK, Sohn JH, Kim J, Kim MY and Kim Y: Evaluation of portal hypertension by real-time shear wave elastography in cirrhotic patients. Liver Int. 35:2416–2424. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kim MY, Jeong WK and Baik SK: Invasive and non-invasive diagnosis of cirrhosis and portal hypertension. World J Gastroenterol. 20:4300–4315. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Abraldes JG, Sarlieve P and Tandon P: Measurement of portal pressure. Clin Liver Dis. 18:779–792. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Silva-Junior G, Baiges A, Turon F, Torres F, Hernández-Gea V, Bosch J and Garcia-Pagan JC: The prognostic value of hepatic venous pressure gradient in patients with cirrhosis is highly dependent on the accuracy of the technique. Hepatology. 62:1584–1592. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Berzigotti A, Reverter E, García-Criado A, Abraldes JG, Cerini F, García-Pagán JC and Bosch J: Reliability of the estimation of total hepatic blood flow by Doppler ultrasound in patients with cirrhotic portal hypertension. J Hepatol. 59:717–722. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Lemoine M, Katsahian S, Ziol M, Nahon P, Ganne-Carrie N, Kazemi F, Grando-Lemaire V, Trinchet JC and Beaugrand M: Liver stiffness measurement as a predictive tool of clinically significant portal hypertension in patients with compensated hepatitis C virus or alcohol-related cirrhosis. Aliment Pharm Ther. 28:1102–1110. 2008. View Article : Google Scholar

28 

Hong WK, Kim MY, Baik SK, Shin SY, Kim JM, Kang YS, Lim YL, Kim YJ, Cho YZ, Hwang HW, et al: The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data. Clin Mol Hepatol. 19:370–375. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Zhang QW, Wang Y, Wang J, Zhao HB, Yu H, Liu SY, Zeng X, Chen Q, Hu ZQ, Guo WY, et al: A non-invasive magnetic resonance imaging-based model predicts portal venous pressure. J Digest Dis. 17:175–185. 2016. View Article : Google Scholar

30 

Hayashi H, Beppu T, Okabe H, Nitta H, Imai K, Doi K, Chikamoto A and Baba H: Combined measurements of serum bile acid level and splenic volume may be useful to noninvasively assess portal venous pressure. J Gastroenterol. 47:1336–1341. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tseng Y, Ma L, Luo T, Zeng X, Li N, Wei Y, Zhou J, Li F and Chen S: Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology. Exp Ther Med 15: 3329-3335, 2018.
APA
Tseng, Y., Ma, L., Luo, T., Zeng, X., Li, N., Wei, Y. ... Chen, S. (2018). Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology. Experimental and Therapeutic Medicine, 15, 3329-3335. https://doi.org/10.3892/etm.2018.5816
MLA
Tseng, Y., Ma, L., Luo, T., Zeng, X., Li, N., Wei, Y., Zhou, J., Li, F., Chen, S."Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology". Experimental and Therapeutic Medicine 15.4 (2018): 3329-3335.
Chicago
Tseng, Y., Ma, L., Luo, T., Zeng, X., Li, N., Wei, Y., Zhou, J., Li, F., Chen, S."Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3329-3335. https://doi.org/10.3892/etm.2018.5816
Copy and paste a formatted citation
x
Spandidos Publications style
Tseng Y, Ma L, Luo T, Zeng X, Li N, Wei Y, Zhou J, Li F and Chen S: Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology. Exp Ther Med 15: 3329-3335, 2018.
APA
Tseng, Y., Ma, L., Luo, T., Zeng, X., Li, N., Wei, Y. ... Chen, S. (2018). Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology. Experimental and Therapeutic Medicine, 15, 3329-3335. https://doi.org/10.3892/etm.2018.5816
MLA
Tseng, Y., Ma, L., Luo, T., Zeng, X., Li, N., Wei, Y., Zhou, J., Li, F., Chen, S."Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology". Experimental and Therapeutic Medicine 15.4 (2018): 3329-3335.
Chicago
Tseng, Y., Ma, L., Luo, T., Zeng, X., Li, N., Wei, Y., Zhou, J., Li, F., Chen, S."Non-invasive predictive model for hepatic venous pressure gradient based on a 3-dimensional computed tomography volume rendering technology". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3329-3335. https://doi.org/10.3892/etm.2018.5816
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