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Article Open Access

Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis

  • Authors:
    • Xia Yang
    • Han‑Lin Wang
    • Hai‑Wei Liang
    • Liang Liang
    • Dong‑Yue Wen
    • Rui Zhang
    • Gang Chen
    • Dan‑Ming Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of General Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530007, P.R. China, Department of Ultrasonography, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3247-3258
    |
    Published online on: February 5, 2018
       https://doi.org/10.3892/etm.2018.5836
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Abstract

Increasing evidence has demonstrated that microRNA (miR)-449a expression is reduced in various types of tumors and that it serves as a tumor suppressor. However, the molecular mechanism of miR‑449a in hepatocellular carcinoma (HCC) has not been thoroughly elucidated and is disputed. Therefore, the aim of the present work was to systematically review the current literature and to utilize the public Gene Expression Omnibus database to determine the role of miR‑449a and its significance in HCC. A total of eight original papers and seven microarrays were included in the present study. Based on the evidence, miR‑449a was reduced in HCC. miR‑449a is likely involved in various signaling pathways and is targeted to multiple mRNA as part of its function in HCC. In addition, a preliminary bioinformatic analysis was conducted for miR-449a to investigate the novel potential pathways that miR-449a may participate in regarding HCC.
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1 

Wan LC, Wang F, Guo X, Lu S, Qiu Z, Zhao Y, Zhang H and Lin J: Identification and characterization of small non-coding RNAs from Chinese fir by high throughput sequencing. BMC Plant Biol. 12:1462012. View Article : Google Scholar : PubMed/NCBI

2 

Bussotti G, Notredame C and Enright AJ: Detecting and comparing non-coding RNAs in the high-throughput era. Int J Mol Sci. 14:15423–15458. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR, Evans JR, Zhao S, et al: The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. 47:199–208. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wang H, Ke C, Ma X, Zhao Q, Yang M, Zhang W and Wang J: MicroRNA-92 promotes invasion and chemoresistance by targeting GSK3β and activating Wnt signaling in bladder cancer cells. Tumour Biol. 37:16295–16304. 2016. View Article : Google Scholar

5 

Cech TR and Steitz JA: The noncoding RNA revolution-trashing old rules to forge new ones. Cell. 157:77–94. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Dhamija S and Diederichs S: From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis. Int J Cancer. 139:269–280. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Wu W, Liu S, Liang Y, Zhou Z and Liu X: MiR-7 inhibits progression of hepatocarcinoma by targeting KLF-4 and promises a novel diagnostic biomarker. Cancer Cell Int. 17:312017. View Article : Google Scholar : PubMed/NCBI

8 

Morey C and Avner P: Employment opportunities for non-coding RNAs. FEBS Lett. 567:27–34. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Ling H, Fabbri M and Calin GA: MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov. 12:847–865. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Dehury B, Panda D, Sahu J, Sahu M, Sarma K, Barooah M, Sen P and Modi M: In silico identification and characterization of conserved miRNAs and their target genes in sweet potato (Ipomoea batatas L.) expressed sequence tags (ESTs). Plant Signal Behav. 8:e265432013. View Article : Google Scholar : PubMed/NCBI

12 

Cong D, He M, Chen S, Liu X, Liu X and Sun H: Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: An analysis of The Cancer Genome Atlas. Onco Targets Ther. 8:2271–2277. 2015.PubMed/NCBI

13 

Polioudakis D, Abell NS and Iyer VR: MiR-191 regulates primary human fibroblast proliferation and directly targets multiple oncogenes. PLoS One. 10:e01265352015. View Article : Google Scholar : PubMed/NCBI

14 

Yuan S, Tang C, Zhang Y, Wu J, Bao J, Zheng H, Xu C and Yan W: mir-34b/c and mir-449a/b/c are required for spermatogenesis, but not for the first cleavage division in mice. Biol Open. 4:212–223. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Kumar P, Sharad S, Petrovics G, Mohamed A, Dobi A, Sreenath TL, Srivastava S and Biswas R: Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1. Oncotarget. 7:22791–22806. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Shi J, Liu Y, Liu J and Zhou J: Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population. Int J Clin Exp Pathol. 8:13387–13392. 2015.PubMed/NCBI

17 

You J, Zhang Y, Li Y, Fang N, Liu B, Zu L and Zhou Q: MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small cell lung cancer. Am J Cancer Res. 5:2730–2744. 2015.PubMed/NCBI

18 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Guo P, Huang ZL, Yu P and Li K: Trends in cancer mortality in China: An update. Ann Oncol. 23:2755–2762. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Center MM and Jemal A: International trends in liver cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 20:2362–2368. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Chen CF, Hsu EC, Lin KT, Tu PH, Chang HW, Lin CH, Chen YJ, Gu DL, Lin CH, Wu JY, et al: Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma. Hepatology. 52:1690–1701. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Takeshima N, Sozu T, Tajika A, Ogawa Y, Hayasaka Y and Furukawa TA: Which is more generalizable, powerful and interpretable in meta-analyses, mean difference or standardized mean difference? BMC Med Res Methodol. 14:302014. View Article : Google Scholar : PubMed/NCBI

23 

Valera EM, Faraone SV, Murray KE and Seidman LJ: Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry. 61:1361–1369. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Sandbothe M, Buurman R, Reich N, Greiwe L, Vajen B, Gürlevik E, Schäffer V, Eilers M, Kühnel F, Vaquero A, et al: The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4. J Hepatol. 66:1012–1021. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Dweep H and Gretz N: miRWalk2.0: A comprehensive atlas of microRNA-target interactions. Nat Methods. 12:6972015. View Article : Google Scholar : PubMed/NCBI

26 

Zhang X, Tang W, Chen G, Ren F, Liang H, Dang Y and Rong M: An encapsulation of gene signatures for hepatocellular carcinoma, MicroRNA-132 predicted target genes and the corresponding overlaps. PLoS One. 11:e01594982016. View Article : Google Scholar : PubMed/NCBI

27 

Lau J, Ioannidis JP and Schmid CH: Quantitative synthesis in systematic reviews. Ann Intern Med. 127:820–826. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Begg CB and Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics. 50:1088–1101. 1994. View Article : Google Scholar : PubMed/NCBI

29 

Wang Q, Huang CS, Yu W, et al: MicroRNA-449a suppresses liver cancer migration and invasion through targeting CXC chemokine ligand 5. Chin J Exp Surg. 34:228–230. 2017.

30 

Liu S, Liu K, Zhang W, Wang Y, Jin Z, Jia B and Liu Y: miR-449a inhibits proliferation and invasion by regulating ADAM10 in hepatocellular carcinoma. Am J Transl Res. 8:2609–2619. 2016.PubMed/NCBI

31 

Chen SP, Liu BX, Xu J, Pei XF, Liao YJ, Yuan F and Zheng F: MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets. BMC Cancer. 15:7062015. View Article : Google Scholar : PubMed/NCBI

32 

Liu Y, Wang Y, Sun X, Mei C, Wang L, Li Z and Zha X: miR-449a promotes liver cancer cell apoptosis by downregulation of Calpain 6 and POU2F1. Oncotarget. 7:13491–13501. 2016.PubMed/NCBI

33 

Zhang X, Liu H, Xie Z, Deng W, Wu C, Qin B, Hou J and Lu M: Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype. Sci Rep. 6:253892016. View Article : Google Scholar : PubMed/NCBI

34 

Sarma NJ, Tiriveedhi V, Subramanian V, Shenoy S, Crippin JS, Chapman WC and Mohanakumar T: Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway. PLoS One. 7:e508262012. View Article : Google Scholar : PubMed/NCBI

35 

El-Serag HB, Kramer J, Duan Z and Kanwal F: Racial differences in the progression to cirrhosis and hepatocellular carcinoma in HCV-infected veterans. Am J Gastroenterol. 109:1427–1435. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F and Skawran B: Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology. 143:811–820.e15. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Murakami Y, Kubo S, Tamori A, Itami S, Kawamura E, Iwaisako K, Ikeda K, Kawada N, Ochiya T and Taguchi YH: Comprehensive analysis of transcriptome and metabolome analysis in intrahepatic cholangiocarcinoma and hepatocellular carcinoma. Sci Rep. 5:162942015. View Article : Google Scholar : PubMed/NCBI

38 

Morita K, Shirabe K, Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T, Yamashita Y, Sugimachi K, Harimoto N, et al: Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation. Liver Transpl. 22:665–676. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Diaz G, Melis M, Tice A, Kleiner DE, Mishra L, Zamboni F and Farci P: Identification of microRNAs specifically expressed in hepatitis C virus-associated hepatocellular carcinoma. Int J Cancer. 133:816–824. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Sato F, Hatano E, Kitamura K, Myomoto A, Fujiwara T, Takizawa S, Tsuchiya S, Tsujimoto G, Uemoto S and Shimizu K: MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan Criteria. PLoS One. 6:e164352011. View Article : Google Scholar : PubMed/NCBI

41 

Liu AM, Yao TJ, Wang W, Wong KF, Lee NP, Fan ST, Poon RT, Gao C and Luk JM: Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: A retrospective cohort study. BMJ Open. 2:e0008252012. View Article : Google Scholar : PubMed/NCBI

42 

Noh JH, Chang YG, Kim MG, Jung KH, Kim JK, Bae HJ, Eun JW, Shen Q, Kim SJ, Kwon SH, et al: MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer. Cancer Lett. 335:455–462. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Martinez-Quetglas I, Pinyol R, Dauch D, Torrecilla S, Tovar V, Moeini A, Alsinet C, Portela A, Rodriguez-Carunchio L, Solé M, et al: IGF2 Is Up-regulated by epigenetic mechanisms in hepatocellular carcinomas and is an actionable oncogene product in experimental models. Gastroenterology. 151:1192–1205. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Petrovic N, Ergün S and Isenovic ER: Levels of MicroRNA heterogeneity in cancer biology. Mol Diagn Ther. 21:511–523. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Luo LJ, Zhang LP, Duan CY, Wang B, He NN, Abulimiti P and Lin Y: The inhibition role of miR-22 in hepatocellular carcinoma cell migration and invasion via targeting CD147. Cancer Cell Int. 17:172017. View Article : Google Scholar : PubMed/NCBI

46 

Xia W, Zhou J, Luo H, Liu Y, Peng C, Zheng W and Ma W: MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7. Cancer Cell Int. 17:142017. View Article : Google Scholar : PubMed/NCBI

47 

Liu C, Li G, Yang N, Su Z, Zhang S, Deng T, Ren S, Lu S, Tian Y, Liu Y and Qiu Y: miR-324-3p suppresses migration and invasion by targeting WNT2B in nasopharyngeal carcinoma. Cancer Cell International. 17:22017. View Article : Google Scholar : PubMed/NCBI

48 

Towler BP, Jones CI and Newbury SF: Mechanisms of regulation of mature miRNAs. Biochem Soc Trans. 43:1208–1214. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Tacke F, Zimmermann HW, Trautwein C and Schnabl B: CXCL5 plasma levels decrease in patients with chronic liver disease. J Gastroenterol Hepatol. 26:523–529. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Yang MH, Chen CL, Chau GY, Chiou SH, Su CW, Chou TY, Peng WL and Wu JC: Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology. 50:1464–1474. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Curtil C, Enache LS, Radreau P, Dron AG, Scholtès C, Deloire A, Roche D, Lotteau V, André P and Ramière C: The metabolic sensors FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus transcription. FASEB J. 28:1454–1463. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Schulze K, Imbeaud S, Letouze E, Alexandrov LB, Calderaro J, Rebouissou S, Couchy G, Meiller C, Shinde J, Soysouvanh F, et al: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 47:505–511. 2015. View Article : Google Scholar : PubMed/NCBI

53 

ClinicalTrials.gov: A multicenter phase I study of MRX34, microRNA miR-RX34 liposomal injection, NCT01829971. 2013.

54 

Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr and Levy DE: Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol. 12:3315–3324. 1992. View Article : Google Scholar : PubMed/NCBI

55 

Yang H, Huang ZZ, Wang J and Lu SC: The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. FASEB J. 15:1507–1516. 2001. View Article : Google Scholar : PubMed/NCBI

56 

Wan Z, Zhi N, Wong S, Keyvanfar K, Liu D, Raghavachari N, Munson PJ, Su S, Malide D, Kajigaya S and Young NS: Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors. J Clin Invest. 120:3530–3544. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Chen HZ, Tsai SY and Leone G: Emerging roles of E2Fs in cancer: An exit from cell cycle control. Nat Rev Cancer. 9:785–797. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Jiang Y, Yim SH, Xu HD, Jung SH, Yang SY, Hu HJ, Jung CK and Chung YJ: A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. World J Gastroenterol. 17:470–477. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Suryadinata R, Sadowski M and Sarcevic B: Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates. Biosci Rep. 30:243–255. 2010. View Article : Google Scholar : PubMed/NCBI

60 

Iyirhiaro GO, Im DS, Boonying W, Callaghan SM, During MJ, Slack RS and Park DS: Cdc25A Is a critical mediator of ischemic neuronal death in vitro and in vivo. J Neurosci. 37:6729–6740. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Shi Y, Qian ZR, Zhang S, Li W, Masugi Y, Li T, Chan JA, Yang J, Da Silva A, Gu M, et al: Cell cycle protein expression in neuroendocrine tumors: Association of CDK4/CDK6, CCND1, and phosphorylated retinoblastoma protein with proliferative index. Pancreas. 46:1347–1353. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Shang A, Lu WY, Yang M, Zhou C, Zhang H, Cai ZX, Wang WW, Wang WX and Wu GQ: miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway. Artif Cells Nanomed Biotechnol. 1–9. 2017. View Article : Google Scholar

63 

Lulla AR, Slifker MJ, Zhou Y, Lev A, Einarson MB, Dicker DT and El-Deiry WS: miR-6883 family miRNAs target CDK4/6 to induce G1 phase cell cycle arrest in colon cancer cells. Cancer Res. 77:6902–6913. 2017. View Article : Google Scholar : PubMed/NCBI

64 

Dall'Acqua A, Sonego M, Pellizzari I, Pellarin I, Canzonieri V, D'Andrea S, Benevol S, Sorio R, Giorda G, Califano D, et al: CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation. EMBO Mol Med. 9:1415–1433. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Zhu H, Wang G, Zhou X, Song X, Gao H, Ma C, Chang H, Li H, Liu FF, Lu J and Ma J: miR-1299 suppresses cell proliferation of hepatocellular carcinoma (HCC) by targeting CDK6. Biomed Pharmacother. 83:792–797. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Wu H, Tao J, Li X, Zhang T, Zhao L, Wang Y, Zhang L, Xiong J, Zeng Z, Zhan N, et al: MicroRNA-206 prevents the pathogenesis of hepatocellular carcinoma by modulating expression of met proto-oncogene and cyclin-dependent kinase 6 in mice. Hepatology. 66:1952–1967. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS and Kiyokawa H: The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. Mol Cell Biol. 21:4818–4828. 2001. View Article : Google Scholar : PubMed/NCBI

68 

Sur S and Agrawal DK: Phosphatases and kinases regulating CDC25 activity in the cell cycle: Clinical implications of CDC25 overexpression and potential treatment strategies. Mol Cell Biochem. 416:33–46. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Wang HL, Liang HW, Liang L, Wen DY, Zhang R, Chen G and Wei DM: Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis. Exp Ther Med 15: 3247-3258, 2018.
APA
Yang, X., Wang, H., Liang, H., Liang, L., Wen, D., Zhang, R. ... Wei, D. (2018). Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis. Experimental and Therapeutic Medicine, 15, 3247-3258. https://doi.org/10.3892/etm.2018.5836
MLA
Yang, X., Wang, H., Liang, H., Liang, L., Wen, D., Zhang, R., Chen, G., Wei, D."Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis". Experimental and Therapeutic Medicine 15.4 (2018): 3247-3258.
Chicago
Yang, X., Wang, H., Liang, H., Liang, L., Wen, D., Zhang, R., Chen, G., Wei, D."Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3247-3258. https://doi.org/10.3892/etm.2018.5836
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Wang HL, Liang HW, Liang L, Wen DY, Zhang R, Chen G and Wei DM: Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis. Exp Ther Med 15: 3247-3258, 2018.
APA
Yang, X., Wang, H., Liang, H., Liang, L., Wen, D., Zhang, R. ... Wei, D. (2018). Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis. Experimental and Therapeutic Medicine, 15, 3247-3258. https://doi.org/10.3892/etm.2018.5836
MLA
Yang, X., Wang, H., Liang, H., Liang, L., Wen, D., Zhang, R., Chen, G., Wei, D."Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis". Experimental and Therapeutic Medicine 15.4 (2018): 3247-3258.
Chicago
Yang, X., Wang, H., Liang, H., Liang, L., Wen, D., Zhang, R., Chen, G., Wei, D."Clinical significance of microRNA-449a in hepatocellular carcinoma with microarray data mining together with initial bioinformatics analysis". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3247-3258. https://doi.org/10.3892/etm.2018.5836
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