Open Access

Human fibroblast growth factor-21 serves as a predictor and prognostic factor in patients with hepatitis B cirrhosis combined with adrenal insufficiency

  • Authors:
    • Jian Zhang
    • Junhong Li
    • Junwei Ma
    • Hongxin Wang
    • Yin Yi
  • View Affiliations

  • Published online on: February 6, 2018     https://doi.org/10.3892/etm.2018.5840
  • Pages: 3189-3196
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatitis B cirrhosis is caused by liver cell necrosis, residual liver cell nodular regeneration, connective tissue hyperplasia and fiber formation, which frequently leads to adrenal insufficiency. Previous reports have demonstrated that human fibroblast growth factor (hFGF)‑21 is a multifunctional protein that exhibits potential therapeutic value for metabolic diseases. The present study investigated the diagnostic value of hFGF‑21 and analyzed the potential molecular mechanism in the progression of hepatitis B cirrhosis combined with adrenal insufficiency. Characteristics of cellular immunity and humoral immunity were analyzed in patients with hepatitis B cirrhosis combined with adrenal insufficiency (PhbA). Results demonstrated that expression levels of hFGF‑21 were downregulated in plasma and liver cells isolated from clinical specimens. Plasma concentration levels of hFGF‑21 were upregulated in prognostic PhbA. In vitro assays indicated that hFGF‑21 treatment decreased the continuous deposition of extracellular matrix and reactive oxygen species in liver cells isolated from clinical specimens. Results also demonstrated that hFGF‑21 treatment downregulated inflammatory cytokines. It was observed that hFGF‑21 treatment downregulated nuclear factor (NF)‑κB and Kruppel‑like factor 6. Notably, transforming growth factor (TGF)‑β, platelet‑derived growth factor and epidermal growth factor levels were improved by hFGF‑21 treatment. In conclusion, these results indicated that hFGF‑21 inhibits inflammation by regulation of the NF‑κB‑mediated TGF‑β signaling pathway, which may serve as a predictor and prognostic factor in PhbA.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang J, Li J, Ma J, Wang H and Yi Y: Human fibroblast growth factor-21 serves as a predictor and prognostic factor in patients with hepatitis B cirrhosis combined with adrenal insufficiency. Exp Ther Med 15: 3189-3196, 2018
APA
Zhang, J., Li, J., Ma, J., Wang, H., & Yi, Y. (2018). Human fibroblast growth factor-21 serves as a predictor and prognostic factor in patients with hepatitis B cirrhosis combined with adrenal insufficiency. Experimental and Therapeutic Medicine, 15, 3189-3196. https://doi.org/10.3892/etm.2018.5840
MLA
Zhang, J., Li, J., Ma, J., Wang, H., Yi, Y."Human fibroblast growth factor-21 serves as a predictor and prognostic factor in patients with hepatitis B cirrhosis combined with adrenal insufficiency". Experimental and Therapeutic Medicine 15.4 (2018): 3189-3196.
Chicago
Zhang, J., Li, J., Ma, J., Wang, H., Yi, Y."Human fibroblast growth factor-21 serves as a predictor and prognostic factor in patients with hepatitis B cirrhosis combined with adrenal insufficiency". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3189-3196. https://doi.org/10.3892/etm.2018.5840