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Article Open Access

GEMALS: A promising therapy for amyotrophic lateral sclerosis

  • Authors:
    • Michel Geffard
    • Arturo Mangas
    • Denis Bedat
    • Rafael Coveñas
  • View Affiliations / Copyright

    Affiliations: Research Department, Institute for Development of Research on Human Pathology and Therapeutics, 33400 Talence, France, Institute of Neurosciences of Castilla y León, Laboratory of Neuroanatomy of The Peptidergic Systems, University of Salamanca, 37007 Salamanca, Spain
    Copyright: © Geffard et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3203-3210
    |
    Published online on: February 14, 2018
       https://doi.org/10.3892/etm.2018.5868
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Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that currently has no cure. At present, the only approved treatment for ALS is Riluzole, a glutamate release blocker that improves life expectancy by 3‑6 months. ALS-Endotherapia (GEMALS) is a novel therapeutic approach to treat ALS and the aim of the present study was to investigate the potential beneficial effects of this novel treatment. A total of 31 patients with ALS were assessed in the current study. Deceleration of the disease was observed in 83.87% (P<0.0001) of patients and mean life expectancy was increased by 38 months. Motor functions, including breathing, walking, salivation, speech, swallowing and writing, were also improved in patients treated with GEMALS. The results of the present study demonstrate that long‑term treatment with GEMALS has a curative effect in patients with ALS. Furthermore, the overall effectiveness of GEMALS was assessed using the ALS Assessment Questionnaire. The score improvement was 76.2 and 100% for men and women, respectively (P<0.0001), compared with the worldwide reference score. The present study provides a promising basis for the use of GEMALS as a therapeutic treatment for patients with ALS; however, these results must be confirmed in a double‑blinded and randomized clinical trial.
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Copy and paste a formatted citation
Spandidos Publications style
Geffard M, Mangas A, Bedat D and Coveñas R: GEMALS: A promising therapy for amyotrophic lateral sclerosis. Exp Ther Med 15: 3203-3210, 2018.
APA
Geffard, M., Mangas, A., Bedat, D., & Coveñas, R. (2018). GEMALS: A promising therapy for amyotrophic lateral sclerosis. Experimental and Therapeutic Medicine, 15, 3203-3210. https://doi.org/10.3892/etm.2018.5868
MLA
Geffard, M., Mangas, A., Bedat, D., Coveñas, R."GEMALS: A promising therapy for amyotrophic lateral sclerosis". Experimental and Therapeutic Medicine 15.4 (2018): 3203-3210.
Chicago
Geffard, M., Mangas, A., Bedat, D., Coveñas, R."GEMALS: A promising therapy for amyotrophic lateral sclerosis". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3203-3210. https://doi.org/10.3892/etm.2018.5868
Copy and paste a formatted citation
x
Spandidos Publications style
Geffard M, Mangas A, Bedat D and Coveñas R: GEMALS: A promising therapy for amyotrophic lateral sclerosis. Exp Ther Med 15: 3203-3210, 2018.
APA
Geffard, M., Mangas, A., Bedat, D., & Coveñas, R. (2018). GEMALS: A promising therapy for amyotrophic lateral sclerosis. Experimental and Therapeutic Medicine, 15, 3203-3210. https://doi.org/10.3892/etm.2018.5868
MLA
Geffard, M., Mangas, A., Bedat, D., Coveñas, R."GEMALS: A promising therapy for amyotrophic lateral sclerosis". Experimental and Therapeutic Medicine 15.4 (2018): 3203-3210.
Chicago
Geffard, M., Mangas, A., Bedat, D., Coveñas, R."GEMALS: A promising therapy for amyotrophic lateral sclerosis". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3203-3210. https://doi.org/10.3892/etm.2018.5868
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