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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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April-2018 Volume 15 Issue 4

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Case Report

Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports

  • Authors:
    • Hisashi Takeuchi
    • Naoto Tokuyama
    • Isao Kuroda
    • Teiichiro Aoyagi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki 300‑0395, Japan
  • Pages: 3976-3980
    |
    Published online on: February 20, 2018
       https://doi.org/10.3892/etm.2018.5882
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Abstract

Molecular targeted therapies have markedly improved the prognosis of metastatic renal cell carcinoma (RCC) and patients are able to receive specific treatments depending on their condition. The cases of two patients who presented with large RCC with very different statuses were examined in the current study. One of the patients was elderly with numerous comorbidities, and the other was young and had Case 1 was an elderly female with various comorbidities including a history of cerebral infarction and impaired eyesight. A 7 cm solid mass in the left kidney, pulmonary metastases and a shrunken right kidney were identified. Conservative treatment was selected and the patient underwent treatment with oral sorafenib for 5 years without experiencing disease progression. Case 2 was a middle‑aged male in a good general condition who had a 19 cm left renal mass and multiple metastases. Due to the tumor size, the patient was initially treated with oral pazopanib to reduce the renal tumor volume and was able to undergo left radical nephrectomy after 6 months. Molecular targeted therapies were thus used to treat these patients taking into account each patient's life stage; case 1 was treated without surgery for six years and case 2 received treatment as a neoadjuvant.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chow WH, Devesa SS, Warren JL and Fraumeni JF Jr: Rising incidence of renal cell cancer in the United States. JAMA. 281:1628–1631. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Fry DE, Amin M and Harbrecht PJ: Rectal obstruction secondary to carcinoma of the prostate. Ann Surgery. 189:488–492. 1979.

Motzer RJ, Bander NH and Nanus DM: Renal cell carcinoma. N Engl J Med. 335:865–875. 1996.

4 

Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, Negrier S, Chevreau C, Solska E, Desai AA, et al: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 356:125–134. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, Staroslawska E, Sosman J, McDermott D, Bodrogi I, et al: Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 356:2271–2281. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, et al: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial. Lancet. 378:1931–1939. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Fuhrman SA, Lasky LC and Limas C: Prognostic signoficance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 6:655–663. 1982. View Article : Google Scholar : PubMed/NCBI

10 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. 7th. Wiley-Blackwell; New Jersey: pp. 255–257. 2009

11 

Pantuck AJ, Zisman A and Belldegrun AS: The changing natural history of renal cell carcinoma. J Urol. 166:1611–1623. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 22:3584–3590. 2009. View Article : Google Scholar

13 

Faivre S, Delbaldo C, Vera K, Robert C, Lozahic S, Lassau N, Bello C, Deprimo S, Brega N, Massimini G, et al: Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol. 1:25–35. 2006. View Article : Google Scholar

14 

Gore ME, Szczylik C, Porta C, Bracarda S, Bjarnason GA, Oudard S, Hariharan S, Lee SH, Haanen J, Castellano D, et al: Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: An expanded-access trial. Lancet Oncol. 8:757–763. 2009. View Article : Google Scholar

15 

Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, et al: Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol. 6:1061–1068. 2010. View Article : Google Scholar

16 

May M, Cindolo L, Zigeuner R, De Cobelli O, Rocco B, De Nunzio C, Tubaro A, Coman I, Truss M, Dalpiaz O, et al: Results of a comparative study analyzing octogenarians with renal cell carcinoma in a competing risk analysis with patients in the seventh decade of life. Urol Oncol. 32:1252–1258. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Escudier B, Szczylik C, Hutson TE, Demkow T, Staehler M, Rolland F, Negrier S, Laferriere N, Scheuring UJ, Cella D, et al: Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma. J Clin Oncol. 8:1280–1289. 2009. View Article : Google Scholar

18 

Zhang HL, Qin XJ, Wang HK, Gu WJ, Ma CG, Shi GH, Zhou LP and Ye DW: Clinicopathological and prognostic factors for long-term survival in Chinese patients with metastatic renal cell carcinoma treated with sorafenib: A single-center retrospective study. Oncotarget. 6:36870–36883. 2015.PubMed/NCBI

19 

Motzer RJ, Escudier B, Tomczak P, Hutson TE, Michaelson MD, Negrier S, Oudard S, Gore ME, Tarazi J, Hariharan S, et al: Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol. 14:552–562. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Akaza H, Naito S, Ueno N, Aoki K, Houzawa H, Pitman Lowenthal S and Lee SY: Real-world use of sunitinib in Japanese patients with advanced renal cell carcinoma: Efficacy, safety and biomarker analyses in 1689 consecutive patients. Jpn J Clin Oncol. 45:576–583. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Mickisch GH, Garin A, van Poppel H, de Prijck L and Sylvester R; European organisation for research and treatment of cancer (EORTC) genitourinary Group, : Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: A randomised trial. Lancet. 358:966–970. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Flanigan RC, Salmon SE, Blumenstein BA, Bearman SI, Roy V, McGrath PC, Caton JR Jr, Munshi N and Crawford ED: Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 345:1655–1659. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Flanigan RC, Mickisch G, Sylvester R, Tangen C, Van Poppel H and Crawford ED: Cytoreductive nephrectomy in patients with metastatic renal cancer: A combined analysis. J Urol. 171:1071–1076. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Choueiri TK, Xie W, Kollmannsberger C, North S, Knox JJ, Lampard JG, McDermott DF, Rini BI and Heng DY: The impact of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor targeted therapy. J Urol. 185:60–66. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, Eigl BJ, Ruether JD, Cheng T, North S, et al: Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. J Clin Oncol. 27:5794–5799. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wood CG and Margulis V: Neoadjuvant (presurgical) therapy for renal cell carcinoma: A new treatment paradigm for locally advanced and metastatic disease. Cancer. 115 10 Suppl:S2355–S2360. 2009. View Article : Google Scholar

27 

Powles T, Blank C, Chowdhury S, Horenblas S, Peters J, Shamash J, Sarwar N, Boleti E, Sahdev A, O'Brien T, et al: The outcome of patients treated with sunitinib prior to planned nephrectomy in metastatic clear cell renal cancer. Eur Urol. 60:448–454. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Bex A, Blank C, Meinhardt W, van Tinteren H, Horenblas S and Haanen J: A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ. Urology. 78:832–837. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Takeuchi H, Tokuyama N, Kuroda I and Aoyagi T: Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports. Exp Ther Med 15: 3976-3980, 2018.
APA
Takeuchi, H., Tokuyama, N., Kuroda, I., & Aoyagi, T. (2018). Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports. Experimental and Therapeutic Medicine, 15, 3976-3980. https://doi.org/10.3892/etm.2018.5882
MLA
Takeuchi, H., Tokuyama, N., Kuroda, I., Aoyagi, T."Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports". Experimental and Therapeutic Medicine 15.4 (2018): 3976-3980.
Chicago
Takeuchi, H., Tokuyama, N., Kuroda, I., Aoyagi, T."Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3976-3980. https://doi.org/10.3892/etm.2018.5882
Copy and paste a formatted citation
x
Spandidos Publications style
Takeuchi H, Tokuyama N, Kuroda I and Aoyagi T: Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports. Exp Ther Med 15: 3976-3980, 2018.
APA
Takeuchi, H., Tokuyama, N., Kuroda, I., & Aoyagi, T. (2018). Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports. Experimental and Therapeutic Medicine, 15, 3976-3980. https://doi.org/10.3892/etm.2018.5882
MLA
Takeuchi, H., Tokuyama, N., Kuroda, I., Aoyagi, T."Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports". Experimental and Therapeutic Medicine 15.4 (2018): 3976-3980.
Chicago
Takeuchi, H., Tokuyama, N., Kuroda, I., Aoyagi, T."Molecular targeted therapies of renal cell carcinoma considering life stage of the patient: Two case reports". Experimental and Therapeutic Medicine 15, no. 4 (2018): 3976-3980. https://doi.org/10.3892/etm.2018.5882
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