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Article

Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate

  • Authors:
    • Wen‑Jie Li
    • You‑Wen Lian
    • Quan‑Sheng Guan
    • Ning Li
    • Wen‑Jun Liang
    • Wen‑Xin Liu
    • Yong‑Bin Huang
    • Yi Cheng
    • Hui Luo
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Laboratory Animal Center, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China, Chemistry Teaching and Research Section, The Key Laboratory of Zhanjiang for R&D Marine Microbial Resources in The Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China
  • Pages: 925-930
    |
    Published online on: May 23, 2018
       https://doi.org/10.3892/etm.2018.6210
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Abstract

Liver‑targeted drug delivery improves the efficacy of anti‑liver cancer agents and reduces systemic toxicity by limiting the bioavailability of these drugs to within tumors. Liver targeting reagents with galactose residues, which selectively combine to asialoglyco protein receptors, have previously been used to improve liposome‑encapsulated drug accumulation within liver cells. They lead to a reduction in liver cancer cell growth and have been used to cure certain hepatic diseases. In the present study, curcumol, which is the primary active component of Chinese traditional medicine Rhizoma zedoariae, was encapsulated in galactosylated‑liposomes to enhance its anti‑liver cancer efficacy. Galactosylated‑liposomes and normal liposomes were labeled with propidium iodide. Galactosylated‑liposomes with increasing concentrations of galactosylated‑stearate (Gal‑s) had a notably increased level of uptake in HepG2 cells (hepatoblastoma) compared with SGC‑7901 (gastric cancer) and A549 (non‑small cell lung cancer) cells. When the percentage of Gal‑s reached 20%, liposome uptake plateaued. In the in vitro anti‑liver cancer experiment, the anti‑liver cancer efficacy of galactosylated‑curcumol‑liposomes increased significantly more compared with normal curcumol liposomes and free curcumol as indicated by cell survival rate and lactate dehydrogenase release rate. Collectively, these results demonstrate that galactosylated‑liposomes are able to enhance the in vitro liver‑targeting effect and anti‑liver cancer efficacy of curcumol.
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1 

Jing F and Hongyang W: Precision diagnosis and treatment of liver cancer in China. Cancer Letters. 412:283–288. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Yang H, Woo HY, Lee SK, Han JW, Jang B, Nam HC, Lee HL, Lee SW, Song DS, Song MJ, et al: A comparative study of sorafenib and metronomic chemotherapy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma with poor liver function. Clin Mol Hepatol. 23:128–137. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Mugada V, Ramineni H and Padala D: 5-Fluorouracil induced severe febrile neutropenia and death. J Young Pharm. 9:133–134. 2017. View Article : Google Scholar

4 

Nematbakhsh M, Pezeshki Z, Eshraghi Jazi F, Mazaheri B, Moeini M, Safari T, Azarkish F, Moslemi F, Maleki M, Rezaei A, et al: Cisplatin-induced nephrotoxicity; protective supplements and gender differences. Asian Pac J Cancer Prev. 18:295–314. 2017.PubMed/NCBI

5 

Oun R and Rowan E: Cisplatin induced arrhythmia; electrolyte imbalance or disturbance of the SA node? Eur J Pharmacol. 811:125–128. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Jia WX, Zhao HB, Chen GJ and Zhang CY: Using drug thinking of Traditional Chinese Medicine on liver cancer. Chin J Basic Med Tradi Chin Med. 23:121–123. 2017.(In Chinese).

7 

Guo P, Liang G and Yang S: Research progresses of curcumol in medicine. China Med. 11:768–772. 2016.(In Chinese).

8 

Zang S, Tang Q, Dong F, Liu H, Li L, Guo F, Pan X, Lin H, Zeng W, Cai Z, et al: Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1. Oncol Report. 38:3583–3591. 2017.

9 

Ling G, Xiaofang X, Xiaoping Y, Jian W and Zhao J: Effects of curcumol-β-cyclodextrin inclusion compound on proliferation and cell cycle of human hepatocarcinoma cell line Bel-7404. China Mod Doct. 16:11–14. 2015.

10 

Hossen MS, Tanvir EM, Prince MB, Paul S, Saha M, Ali MY, Gan SH, Khalil MI and Karim N: Protective mechanism of turmeric (Curcuma longa) on carbofuran-induced hematological and hepatic toxicities in a rat model. Pharm Biol. 55:1937–1945. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Mengqing S, Yongxing D, Zongze L, Lei Y, Hong S and Ziwen L: 5-Fluorouracil suppresses human hepatocellular carcinoma cell growth via promoting miR-22 expression. Basic Clin Med. 37:1368–1372. 2017.(In Chinese).

12 

Hua L and Dong'ang Z: Matrine injection for enhanced sensitivity to cisplatin in chemotherapy for liver cancer. Pract J Cancer. 32:1659–1662. 2017.(In Chinese).

13 

Zhe M, Fang W, Xin J and Yu L: Preformulation study of curcumol. Int Pharm Res. 43:561–563. 2016.(In Chinese).

14 

Ting W and Xiaokun L: Study on technology of preparation and quality evaluation of curcumol liposome. Chin Arch Tradit Chin Med. 33:2687–2689. 2015.

15 

Darwish WM, Bayoumi NA and El-Kolaly MT: Laser-responsive liposome for selective tumor targeting of nitazoxanide nanoparticles. Eur J Pharm Sci. 111:526–533. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Joseph RR, Tan DWN, Ramon MRM, Natarajan JV, Agrawal R, Wong TT and Venkatraman SS: Characterization of liposomal carriers for the trans-scleral transport of Ranibizumab. Sci Rep. 7:168032017. View Article : Google Scholar : PubMed/NCBI

17 

Aryasomayajula B, Salzano G and Torchilin VP: Multifunctional Liposomes. Methods Mol Biol. 1530:41–61. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Zhao M, Ding XF, Shen JY, Zhang XP, Ding XW and Xu B: Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice. J Zhejiang Univ Sci B. 18:15–26. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Zununi Vahed S, Salehi R, Davaran S and Sharifi S: Liposome-based drug co-delivery systems in cancer cells. Mater Sci Eng C Mater Biol Appl. 71:1327–1341. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Koshy ST, Cheung AS, Gu L, Graveline AR and Mooney DJ: Liposomal delivery enhances immune activation by STING agonists for cancer immunotherapy. Advanced Biosystems. 1:1–19. 2017. View Article : Google Scholar

21 

Oh HR, Jo HY, Park JS, Kim DE, Cho JY, Kim PH and Kim KS: Galactosylated liposomes for targeted co-delivery of Doxorubicin/Vimentin siRNA to hepatocellular carcinoma. Nanomaterials. 6:E1412016. View Article : Google Scholar : PubMed/NCBI

22 

Mbatha L, Chakravorty S, de Koning CB, van Otterlo WA, Arbuthnot P, Ariatti M and Singh M: Spacer length: A determining factor in the design of galactosyl ligands for hepatoma cell-specific liposomal gene delivery. Curr Drug Deliv. 13:935–945. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Luo LH, Zheng PJ, Nie H, Chen YC, Tong D, Chen J and Cheng Y: Pharmacokinetics and tissue distribution of docetaxel liposome mediated by a novel galactosylated cholesterol derivatives synthesized by lipase-catalyzed esterification in non-aqueous phase. Drug Deliv. 23:1282–1290. 2016.PubMed/NCBI

24 

Jiang PL, Lin HJ, Wang HW, Tsai WY, Lin SF, Chien MY, Liang PH, Huang YY and Liu DZ: Galactosylated liposome as a dendritic cell-targeted mucosal vaccine for inducing protective anti-tumor immunity. Acta Biomater. 11:356–367. 2015. View Article : Google Scholar : PubMed/NCBI

25 

López-Terrada D, Cheung SW, Finegold MJ and Knowles BB: HepG2 is a hepatoblastoma-derived cell line. Hum Pathol. 40:1512–1515. 2009. View Article : Google Scholar

26 

Cheng D, Meng M, Zhang X and Wang C: An anti-tumor peptide from Musca Domestica Pupae (MATP) induces apoptosis in human liver cancer cells HepG2 cells through a ROS-JNK pathway. Internat J Pept Res Ther. 23:101–109. 2017. View Article : Google Scholar

27 

Cui H, Li W and Lin L: Antibacterial activity of liposome containing curry plant essential oil against Bacillus cereus in rice. J Food Saf. 37:1–8. 2017. View Article : Google Scholar

28 

Ping S, Chunhui Z, Jing H and Dongbin H: The curcumol inhibitory effect on HNE1 cell of nasopharyngeal carcinoma in tumor-bearing mouse mode. Lab Anim Sci. 34:18–22. 2017.

29 

Zhang L, Ding L, Tang C, Li Y and Yang L: Liraglutide-loaded multivesicular liposome as a sustained-delivery reduces blood glucose in SD rats with diabetes. Drug Deliv. 23:3358–3363. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Wenjie L, Hui L, Qiuqiang Y, Juxiang Z, Zhenbin J and Yi C: Rapid determination of entrapment efficiency of zedoary turmeric oil liposomes by extraction-chromogenic method. J N Pharm. 10:3–6. 2013.

31 

Xiao Z: Research of curcumenol intravenous submicron emulsion. Peking Union Med Coll. 2008

32 

Ma Y, Chen H, Su S, Wang T, Zhang C, Fida G, Cui S, Zhao J and Gu Y: Galactose as Broad ligand for multiple tumor imaging and therapy. J Cancer. 6:658–670. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Pathak PO, Nagarsenker MS, Barhate CR, Padhye SG, Dhawan VV, Bhattacharyya D, Viswanathan CL, Steiniger F and Fahr A: Cholesterol anchored arabinogalactan for asialoglycoprotein receptor targeting: Synthesis, characterization, and proof of concept of hepatospecific delivery. Carbohydr Res. 408:33–43. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Li Y, Huang G, Diakur J and Wiebe LI: Targeted delivery of macromolecular drugs: Asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell Lines used in antiviral drug development. Curr Drug Deliv. 5:299–302. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Xu H, Hu M, Yu X, Li Y, Fu Y, Zhou X, Zhang D and Li J: Design and evaluation of pH-sensitive liposomes constructed by poly (2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery. Eur J Biopharm. 91:66–74. 2015. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li WJ, Lian YW, Guan QS, Li N, Liang WJ, Liu WX, Huang YB, Cheng Y and Luo H: Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate. Exp Ther Med 16: 925-930, 2018.
APA
Li, W., Lian, Y., Guan, Q., Li, N., Liang, W., Liu, W. ... Luo, H. (2018). Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate. Experimental and Therapeutic Medicine, 16, 925-930. https://doi.org/10.3892/etm.2018.6210
MLA
Li, W., Lian, Y., Guan, Q., Li, N., Liang, W., Liu, W., Huang, Y., Cheng, Y., Luo, H."Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate". Experimental and Therapeutic Medicine 16.2 (2018): 925-930.
Chicago
Li, W., Lian, Y., Guan, Q., Li, N., Liang, W., Liu, W., Huang, Y., Cheng, Y., Luo, H."Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate". Experimental and Therapeutic Medicine 16, no. 2 (2018): 925-930. https://doi.org/10.3892/etm.2018.6210
Copy and paste a formatted citation
x
Spandidos Publications style
Li WJ, Lian YW, Guan QS, Li N, Liang WJ, Liu WX, Huang YB, Cheng Y and Luo H: Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate. Exp Ther Med 16: 925-930, 2018.
APA
Li, W., Lian, Y., Guan, Q., Li, N., Liang, W., Liu, W. ... Luo, H. (2018). Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate. Experimental and Therapeutic Medicine, 16, 925-930. https://doi.org/10.3892/etm.2018.6210
MLA
Li, W., Lian, Y., Guan, Q., Li, N., Liang, W., Liu, W., Huang, Y., Cheng, Y., Luo, H."Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate". Experimental and Therapeutic Medicine 16.2 (2018): 925-930.
Chicago
Li, W., Lian, Y., Guan, Q., Li, N., Liang, W., Liu, W., Huang, Y., Cheng, Y., Luo, H."Liver‑targeted delivery of liposome‑encapsulated curcumol using galactosylated‑stearate". Experimental and Therapeutic Medicine 16, no. 2 (2018): 925-930. https://doi.org/10.3892/etm.2018.6210
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