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Article

TTB2 induces apoptosis in Ewing sarcoma cells

  • Authors:
    • Xueling Zou
    • Wenfeng Huang
  • View Affiliations / Copyright

    Affiliations: Hubei Key Laboratory of Natural Products Research and Development, Medical College, China Three Gorges University, Yichang, Hubei 443002, P.R. China
  • Pages: 1021-1025
    |
    Published online on: May 30, 2018
       https://doi.org/10.3892/etm.2018.6236
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Abstract

A steroidal saponin named pennogenin 3-O-α-­L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→4)]-β-D-glucoyranoside(TTB2) has been successfully separated from the n‑BuOH extracts of Trillium tschonoskii Maxim and is able to induce cytotoxicity to some types cancer cells. The present study aimed to investigate how this novel saponinin duces cytotoxicity in malignant sarcoma cells and to clarify its molecular mechanisms of action. It was determined this steroidal saponin induced the apoptosis in Rh1 cells and activated caspase‑3 and caspase‑9. Additionally, it disrupted the mitochondrial membrane potential and altered the expression of bax and bcl‑2. Thus, the results of present study identified that an anticancer saponin isolated from Trillium tschonoskii Maxim may be developed as a potential novel therapeutic strategy to treat certain types of cancer, including lung cancer and lung sarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zou X and Huang W: TTB2 induces apoptosis in Ewing sarcoma cells. Exp Ther Med 16: 1021-1025, 2018.
APA
Zou, X., & Huang, W. (2018). TTB2 induces apoptosis in Ewing sarcoma cells. Experimental and Therapeutic Medicine, 16, 1021-1025. https://doi.org/10.3892/etm.2018.6236
MLA
Zou, X., Huang, W."TTB2 induces apoptosis in Ewing sarcoma cells". Experimental and Therapeutic Medicine 16.2 (2018): 1021-1025.
Chicago
Zou, X., Huang, W."TTB2 induces apoptosis in Ewing sarcoma cells". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1021-1025. https://doi.org/10.3892/etm.2018.6236
Copy and paste a formatted citation
x
Spandidos Publications style
Zou X and Huang W: TTB2 induces apoptosis in Ewing sarcoma cells. Exp Ther Med 16: 1021-1025, 2018.
APA
Zou, X., & Huang, W. (2018). TTB2 induces apoptosis in Ewing sarcoma cells. Experimental and Therapeutic Medicine, 16, 1021-1025. https://doi.org/10.3892/etm.2018.6236
MLA
Zou, X., Huang, W."TTB2 induces apoptosis in Ewing sarcoma cells". Experimental and Therapeutic Medicine 16.2 (2018): 1021-1025.
Chicago
Zou, X., Huang, W."TTB2 induces apoptosis in Ewing sarcoma cells". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1021-1025. https://doi.org/10.3892/etm.2018.6236
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