Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2018 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet

  • Authors:
    • Jianbo Huang
    • Yangpeng Wang
    • Chao Ying
    • Lei Liu
    • Zhaohuan Lou
  • View Affiliations / Copyright

    Affiliations: Department of Basic Theory of Traditional Chinese Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Institute of Materia Medica, College of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, Institute of Materia Medica, College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 547-556
    |
    Published online on: June 6, 2018
       https://doi.org/10.3892/etm.2018.6254
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hypercholesterolemia is a major risk factor for cardiovascular disease. Mulberry leaf (ML) is a Traditional Chinese Medicine used to treat hyperlipidemia in clinical settings. The aim of the present study was to identify the potential effect and possible target of ML in anti‑hypercholesterolemia. Male Sprague‑Dawley rats were fed with a high‑fat diet and treated with ML for 5 weeks. Blood lipid levels, total cholesterol (TC) and total bile acid (TBA) in the liver and feces were measured to assess the effects of ML on hypercholesterolemia. Harris's hematoxylin staining and oil red O staining was applied to observe the pathological change and lipid accumulation in the liver. Immunohistochemical assay was performed to observe the location of expressions of scavenger receptor class B type I and low‑density lipoprotein (LDL) receptor (‑R), and western blotting was applied to determine the protein expression of ATP‑binding cassette transporter G5/G8 (ABCG5/8), nuclear transcription factor peroxisome proliferator‑activated receptor‑α (PPARα), farnesoid‑X receptor (FXR) and cholesterol 7α‑hydroxylase 1 (CYP7A1). The results demonstrated that ML treatment reduced serum TC and LDL‑cholesterol levels, and liver TC and TBA contents; increased serum HDL‑C levels, and fecal TC and TBA contents; and alleviated hepatocyte lipid degeneration. In addition, ML treatment inhibited liver LDL‑R, PPARα and FXR protein expression, promoted protein expression of CYP7A1, and maintained the ratio of ABCG5/ABCG8. The findings of the present study provide a positive role of ML on cholesterol clearance via promoting cholesterol and TBA execration via FXR‑ and CYP7A1‑mediated pathways; RCT regulation may be a potential mechanism of ML on anti‑hypercholesterolemia.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Navar-Boggan AM, Peterson ED, D'Agostino RB Sr, Neely B, Sniderman AD and Pencina MJ: Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation. 131:451–458. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Garcia GH, Liu JN, Wong A, Cordasco F, Dines DM, Dines JS, Gulotta LV and Warren R: Hyperlipidemia increases the risk of retear after arthroscopic rotator cuff repair. J Shoulder Elbow Surg. 26:2086–2090. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Bjornsson E, Jacobsen EI and Kalaitzakis E: Hepatotoxicity associated with statins: Reports of idiosyncratic liver injury post-marketing. J Hepatol. 56:374–380. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Graham DJ, Staffa JA, Shatin D, Andrade SE, Schech SD, La Grenade L, Gurwitz JH, Chan KA, Goodman MJ and Platt R: Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs. JAMA. 292:2585–2590. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Sakamoto K, Honda T, Yokoya S, Waguri S and Kimura J: Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers. FASEB J. 21:4087–4094. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Chu SM, Shih WT, Yang YH, Chen PC and Chu YH: Use of traditional Chinese medicine in patients with hyperlipidemia: A population-based study in Taiwan. J Ethnopharmacol. 168:129–135. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Cai S, Sun W, Fan Y, Guo X, Xu G, Xu T, Hou Y, Zhao B, Feng X and Liu T: Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats. Pharm Biol. 54:2685–2691. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Salemi Z, Barzin Tond S, Fallah S, Shojaii A and Seifi M: The effect of Morus alba leaves extract and powder on resistin levels and liver transaminase enzymes activities in diabetes. Cell Mol Biol (Noisy-le-Grand). 62:112–118. 2016.PubMed/NCBI

9 

Zhang Y, Ren C, Lu G, Cui W, Mu Z, Gao H and Wang Y: Purification, characterization and anti-diabetic activity of a polysaccharide from mulberry leaf. Regul Toxicol Pharmacol. 70:687–695. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Khan MA, Rahman AA, Islam S, Khandokhar P, Parvin S, Islam MB, Hossain M, Rashid M, Sadik G, Nasrin S, et al: A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae). BMC Res Notes. 6:242013. View Article : Google Scholar

11 

Lee YJ, Hsu JD, Lin WL, Kao SH and Wang CJ: Upregulation of caveolin-1 by mulberry leaf extract and its major components, chlorogenic acid derivatives, attenuates alcoholic steatohepatitis via inhibition of oxidative stress. Food Funct. 8:397–405. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Jeong JW, Lee HH, Lee KW, Kim KY, Kim SG, Hong SH, Kim GY, Park C, Kim HK, Choi YW and Choi YH: Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. Int J Mol Med. 37:452–460. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ann JY, Eo H and Lim Y: Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice. Genes Nutr. 10:462015. View Article : Google Scholar : PubMed/NCBI

14 

Sugimoto M, Arai H, Tamura Y, Murayama T, Khaengkhan P, Nishio T, Ono K, Ariyasu H, Akamizu T, Ueda Y, et al: Mulberry leaf ameliorates the expression profile of adipocytokines by inhibiting oxidative stress in white adipose tissue in db/db mice. Atherosclerosis. 204:388–394. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Enkhmaa B, Shiwaku K, Katsube T, Kitajima K, Anuurad E, Yamasaki M and Yamane Y: Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr. 135:729–734. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Aramwit P, Petcharat K and Supasyndh O: Efficacy of mulberry leaf tablets in patients with mild dyslipidemia. Phytother Res. 25:365–369. 2011.PubMed/NCBI

17 

Aramwit P, Supasyndh O, Siritienthong T and Bang N: Mulberry leaf reduces oxidation and C-reactive protein level in patients with mild dyslipidemia. Biomed Res Int. 2013:7879812013. View Article : Google Scholar : PubMed/NCBI

18 

Kobayashi Y, Miyazawa M, Kamei A, Abe K and Kojima T: Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: Induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress. Biosci Biotechnol Biochem. 74:2385–2395. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Lou Z, Zhang G, Su J, Xia B, Yu J and Yan M: Effect of green tea and mulberry leaf powder on serum lipid profile in rats with hyperlipidemia. Zhongchengyao. 38:1594–1597. 2016.(In Chinese).

20 

Trimarco V, Izzo R, Stabile E, Rozza F, Santoro M, Manzi MV, Serino F, Schiattarella GG, Esposito G and Trimarco B: Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial. High Blood Press Cardiovasc Prev. 22:149–154. 2015. View Article : Google Scholar

21 

Valacchi G, Belmonte G, Miracco C, Eo H and Lim Y: Effect of combined mulberry leaf and fruit extract on liver and skin cholesterol transporters in high fat diet-induced obese mice. Nutr Res Pract. 8:20–26. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Riwanto M and Landmesser U: High density lipoproteins and endothelial functions: Mechanistic insights and alterations in cardiovascular disease. J Lipid Res. 54:3227–3243. 2013. View Article : Google Scholar : PubMed/NCBI

23 

van der Velde AE, Vrins CL, van den Oever K, Seemann I, Oude Elferink RP, van Eck M, Kuipers F and Groen AK: Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol. 295:G203–G208. 2008. View Article : Google Scholar : PubMed/NCBI

24 

The State Science and Technology Commission of China: Regulations on the management of laboratory animals. Shiyong Qiguan Yizhi Zazhi. 4:66–67. 2016.(In Chinese).

25 

Ministry of Science and Technology of the People's Republic of China: 2018, Methods for managing experimental animal licenses (trial). [online] Available at:. http://www.most.gov.cn/fggw/zfwj/zfwj2001/zf01yw/zf01kjjh/200312/t20031209_31332.htmJuly 30–2015

26 

Brown MS and Goldstein JL: A receptor-mediated pathway for cholesterol homeostasis. Science. 232:34–47. 1986. View Article : Google Scholar : PubMed/NCBI

27 

Huby T, Doucet C, Dachet C, Ouzilleau B, Ueda Y, Afzal V, Rubin E, Chapman MJ and Lesnik P: Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues. J Clin Invest. 116:2767–2776. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Braamskamp MJ, Hutten BA and Wiegman A: Early initiation of statin treatment in children with familial hypercholesterolaemia. Curr Opin Lipidol. 26:236–239. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Yakushiji E, Ayaori M, Nishida T, Shiotani K, Takiguchi S, Nakaya K, Uto-Kondo H, Ogura M, Sasaki M, Yogo M, et al: Probucol-oxidized products, spiroquinone and diphenoquinone, promote reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol. 36:591–597. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Wang DQ: Regulation of intestinal cholesterol absorption. Annu Rev Physiol. 69:221–248. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Orsoni A, Villard EF, Bruckert E, Robillard P, Carrie A, Bonnefont-Rousselot D, Chapman MJ, Dallinga-Thie GM, Le Goff W and Guerin M: Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia. J Lipid Res. 53:767–775. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Y, Si Y, Zhai L, Guo S, Zhao J, Sang H, Pang X, Zhang X, Chen A and Qin S: Celastrus orbiculatus thunb. Reduces lipid accumulation by promoting reverse cholesterol transport in hyperlipidemic mice. Lipids. 51:677–692. 2016.

33 

Zhu RG, Sun YD, Hou YT, Fan JG, Chen G and Li TP: Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice. Chem Biol Interact. 272:153–159. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Maxwell KN, Fisher EA and Breslow JL: Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci USA. 102:2069–2074. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Zelcer N, Hong C, Boyadjian R and Tontonoz P: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 325:100–104. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Kosenko T, Golder M, Leblond G, Weng W and Lagace TA: Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation. J Biol Chem. 288:8279–8288. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ji Y, Wang N, Ramakrishnan R, Sehayek E, Huszar D, Breslow JL and Tall AR: Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem. 274:33398–33402. 1999. View Article : Google Scholar : PubMed/NCBI

38 

Braun A, Zhang S, Miettinen HE, Ebrahim S, Holm TM, Vasile E, Post MJ, Yoerger DM, Picard MH, Krieger JL, et al: Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse. Proc Natl Acad Sci USA. 100:7283–7288. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Chulsky S, Paland N, Lazarovich A and Fuhrman B: Urokinase-type plasminogen activator (uPA) decreases hepatic SR-BI expression and impairs HDL-mediated reverse cholesterol transport. Atherosclerosis. 233:11–18. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R and Hobbs HH: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 290:1771–1775. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Wang J, Mitsche MA, Lutjohann D, Cohen JC, Xie XS and Hobbs HH: Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res. 56:319–330. 2015. View Article : Google Scholar : PubMed/NCBI

42 

van der Veen JN, van Dijk TH, Vrins CL, van Meer H, Havinga R, Bijsterveld K, Tietge UJ, Groen AK and Kuipers F: Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J Biol Chem. 284:19211–19219. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Dikkers A, Freak de Boer J, Annema W, Groen AK and Tietge UJ: Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice. Hepatology. 58:293–303. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Cao Y, Bei W, Hu Y, Cao L, Huang L, Wang L, Luo D, Chen Y, Yao X, He W, et al: Hypocholesterolemia of Rhizoma Coptidis alkaloids is related to the bile acid by up-regulated CYP7A1 in hyperlipidemic rats. Phytomedicine. 19:686–692. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Li T, Matozel M, Boehme S, Kong B, Nilsson LM, Guo G, Ellis E and Chiang JY: Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology. 53:996–1006. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G and Gonzalez FJ: Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 102:731–744. 2000. View Article : Google Scholar : PubMed/NCBI

47 

Cai SY, He H, Nguyen T, Mennone A and Boyer JL: Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res. 51:2265–2274. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Kojima Y, Kimura T, Nakagawa K, Asai A, Hasumi K, Oikawa S and Miyazawa T: Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans. J Clin Biochem Nutr. 47:155–161. 2010. View Article : Google Scholar : PubMed/NCBI

49 

Chan KC, Yang MY, Lin MC, Lee YJ, Chang WC and Wang CJ: Mulberry leaf extract inhibits the development of atherosclerosis in cholesterol-fed rabbits and in cultured aortic vascular smooth muscle cells. J Agric Food Chem. 61:2780–2788. 2013. View Article : Google Scholar : PubMed/NCBI

50 

He X, Fang J, Ruan Y, Wang X, Sun Y, Wu N, Zhao Z, Chang Y, Ning N, Guo H and Huang L: Structures, bioactivities and future prospective of polysaccharides from Morus alba (white mulberry): A review. Food Chem. 245:899–910. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang J, Wang Y, Ying C, Liu L and Lou Z: Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet. Exp Ther Med 16: 547-556, 2018.
APA
Huang, J., Wang, Y., Ying, C., Liu, L., & Lou, Z. (2018). Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet. Experimental and Therapeutic Medicine, 16, 547-556. https://doi.org/10.3892/etm.2018.6254
MLA
Huang, J., Wang, Y., Ying, C., Liu, L., Lou, Z."Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet". Experimental and Therapeutic Medicine 16.2 (2018): 547-556.
Chicago
Huang, J., Wang, Y., Ying, C., Liu, L., Lou, Z."Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet". Experimental and Therapeutic Medicine 16, no. 2 (2018): 547-556. https://doi.org/10.3892/etm.2018.6254
Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Wang Y, Ying C, Liu L and Lou Z: Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet. Exp Ther Med 16: 547-556, 2018.
APA
Huang, J., Wang, Y., Ying, C., Liu, L., & Lou, Z. (2018). Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet. Experimental and Therapeutic Medicine, 16, 547-556. https://doi.org/10.3892/etm.2018.6254
MLA
Huang, J., Wang, Y., Ying, C., Liu, L., Lou, Z."Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet". Experimental and Therapeutic Medicine 16.2 (2018): 547-556.
Chicago
Huang, J., Wang, Y., Ying, C., Liu, L., Lou, Z."Effects of mulberry leaf on experimental hyperlipidemia rats induced by high‑fat diet". Experimental and Therapeutic Medicine 16, no. 2 (2018): 547-556. https://doi.org/10.3892/etm.2018.6254
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team