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The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis

  • Authors:
    • Jingru Du
    • Junfeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Orthopedics, The 180th Hospital of PLA (Affiliated Haixia Hospital of Huaqiao University), Quanzhou, Fujian 362008, P.R. China
  • Pages: 1975-1981
    |
    Published online on: July 3, 2018
       https://doi.org/10.3892/etm.2018.6397
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Abstract

Expression and function of Wnt signaling pathway in rats with atherosclerosis (AS) were investegated. The AS model of rats was established after 8-week continuous feeding of a high-fat diet, with normal rats as the control. Blood was taken from the carotid artery to detect the level of blood lipid. Aortic slices were made to observe the pathological changes of the aorta after the rats were sacrificed. Enzyme-linked immunosorbent assay kits were used to detect the contents of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Western blot analysis and semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) were performed to detect the expression levels of related proteins and mRNA in rat Wnt signaling pathway. Correlation analysis between the protein expression level of vascular endothelial growth factor (VEGF) and that of Wnt1 was conducted. Aortic slices showed that the ratio of intima thickness to media thickness of the rats in the model group was higher than that of in the control group (P<0.01). Blood lipid and the contents of IL-6 and TNF-α of the rats in the model group were higher than those of the rats in the control group (P<0.01). Semi‑quantitative RT-PCR indicated that mRNA expression levels of Wnt1, β-catenin and dickkopf1 in the aorta of rats in the model group were increased compared with those of control group (P<0.01). The results of western blot analysis revealed that the protein expression levels of Wnt1, β-catenin, DKK1 and VEGF of the rats in the model group were remarkably higher than those of the control group (P<0.01). The level of VEGF protein was positively correlated with that of Wnt1 (P<0.05, r=0.7810). The activation of Wnt signaling pathway in the aorta of the rats with AS can induce the expression of relevant inflammatory cytokines. It has the effects of promoting the progression of AS and accelerating angiogenesis.
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1 

Dolan H, Crain B, Troncoso J, Resnick SM, Zonderman AB and Obrien RJ: Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort. Ann Neurol. 68:231–240. 2010.PubMed/NCBI

2 

Yamamoto S, Zhong J, Yancey PG, Zuo Y, Linton MF, Fazio S, Yang H, Narita I and Kon V: Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. Atherosclerosis. 242:56–64. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Rose H, Low H, Dewar E, Bukrinsky M, Hoy J, Dart A and Sviridov D: The effect of HIV infection on atherosclerosis and lipoprotein metabolism: A one year prospective study. Atherosclerosis. 229:206–211. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Alberts-Grill N, Denning TL, Rezvan A and Jo H: The role of the vascular dendritic cell network in atherosclerosis. Am J Physiol Cell Physiol. 305:C1–C21. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Bauer AJ and Martin KA: Coordinating regulation of gene expression in cardiovascular disease: Interactions between chromatin modifiers and transcription factors. Front Cardiovasc Med. 4:192017. View Article : Google Scholar : PubMed/NCBI

6 

Gajjala PR, Sanati M and Jankowski J: Cellular and molecular mechanisms of chronic kidney disease with diabetes mellitus and cardiovascular diseases as its comorbidities. Front Immunol. 6:3402015. View Article : Google Scholar : PubMed/NCBI

7 

Garcia-Martín A, Reyes-Garcia R, García-Fontana B, Morales-Santana S, Coto-Montes A, Muñoz-Garach M, Rozas-Moreno P and Muñoz-Torres M: Relationship of Dickkopf1 (DKK1) with cardiovascular disease and bone metabolism in Caucasian type 2 diabetes mellitus. PLoS One. 9:e1117032014. View Article : Google Scholar : PubMed/NCBI

8 

Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, et al: Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 98:E60–E65. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Witztum JL and Lichtman AH: The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol. 9:73–102. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Geng YJ and Jonasson L: Linking immunity to atherosclerosis: Implications for vascular pharmacology - a tribute to Göran K. Hansson. Vascul Pharmacol. 56:29–33. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Taghavie-Moghadam PL, Butcher MJ and Galkina EV: The dynamic lives of macrophage and dendritic cell subsets in atherosclerosis. Ann N Y Acad Sci. 1319:19–37. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Patel KM, Strong A, Tohyama J, Jin X, Morales CR, Billheimer J, Millar J, Kruth H and Rader DJ: Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis. Circ Res. 116:789–796. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Fontes JA, Rose NR and Čiháková D: The varying faces of IL-6: From cardiac protection to cardiac failure. Cytokine. 74:62–68. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Orbay H, Hong H, Zhang Y and Cai W: PET/SPECT imaging of hindlimb ischemia: Focusing on angiogenesis and blood flow. Angiogenesis. 16:279–287. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, et al: Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal Transduct Target Ther. 1:458–463. 2016. View Article : Google Scholar

16 

Xu Y, Chen B, George SK and Liu B: Downregulation of MicroRNA-152 contributes to high expression of DKK1 in multiple myeloma. RNA Biol. 12:1314–1322. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Mozos I and Marginean O: Links between vitamin D deficiency and cardiovascular diseases. BioMed Res Int. 2015:1092752015. View Article : Google Scholar : PubMed/NCBI

18 

Taghavie-Moghadam PL, Gjurich BN, Jabeen R, Krishnamurthy P, Kaplan MH, Dobrian AD, Nadler JL and Galkina EV: STAT4 deficiency reduces the development of atherosclerosis in mice. Atherosclerosis. 243:169–178. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Caliceti C, Nigro P, Rizzo P and Ferrari R: ROS, Notch, and Wnt signaling pathways: Crosstalk between three major regulators of cardiovascular biology. BioMed Res Int. 2014:3187142014. View Article : Google Scholar : PubMed/NCBI

20 

Zhou H, Binmadi NO, Yang YH, Proia P and Basile JR: Semaphorin 4D cooperates with VEGF to promote angiogenesis and tumor progression. Angiogenesis. 15:391–407. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Du J and Li J: The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis. Exp Ther Med 16: 1975-1981, 2018.
APA
Du, J., & Li, J. (2018). The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis. Experimental and Therapeutic Medicine, 16, 1975-1981. https://doi.org/10.3892/etm.2018.6397
MLA
Du, J., Li, J."The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis". Experimental and Therapeutic Medicine 16.3 (2018): 1975-1981.
Chicago
Du, J., Li, J."The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1975-1981. https://doi.org/10.3892/etm.2018.6397
Copy and paste a formatted citation
x
Spandidos Publications style
Du J and Li J: The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis. Exp Ther Med 16: 1975-1981, 2018.
APA
Du, J., & Li, J. (2018). The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis. Experimental and Therapeutic Medicine, 16, 1975-1981. https://doi.org/10.3892/etm.2018.6397
MLA
Du, J., Li, J."The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis". Experimental and Therapeutic Medicine 16.3 (2018): 1975-1981.
Chicago
Du, J., Li, J."The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1975-1981. https://doi.org/10.3892/etm.2018.6397
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