Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions

  • Authors:
    • Ayman G. Mustafa
    • Mahmoud A. Alfaqih
    • Othman Al‑Shboul
  • View Affiliations / Copyright

    Affiliations: Department of Basic Medical Sciences, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan, Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
  • Pages: 2132-2137
    |
    Published online on: July 6, 2018
       https://doi.org/10.3892/etm.2018.6419
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lipid peroxidation is associated with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4‑hydroxyonenal (4‑HNE). The exact mechanism(s) by which 4‑HNE causes damage in the intravascular compartment is not yet exactly understood. Using an in vitro system, the damage induced by 4‑HNE on the blood was investigated by measuring protein carbonyl groups and thiobarbituric acid reactive substances (TBARS) following 4‑HNE treatment. The findings demonstrated that treatment with 4‑HNE increased the carbonylation of protein and the formation of TBARS in the blood plasma. It was also tested whether phenelzine, a scavenger of aldehyde species, or U‑83836E, a scavenger of lipid peroxy radicals, attenuated the damage caused by 4‑HNE. It was demonstrated that phenelzine or U‑83836E both mitigated the effects of 4‑HNE on the proteins and the lipids of the blood plasma. The findings of the current study suggest that phenelzine, U‑83836E or functionally similar therapeutics may prevent or treat diseases that involve an increased production of 4‑HNE in the intravascular compartment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ray PD, Huang BW and Tsuji Y: Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 24:981–990. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Bergamini CM, Gambetti S, Dondi A and Cervellati C: Oxygen, reactive oxygen species and tissue damage. Curr Pharm Des. 10:1611–1626. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Bandyopadhyay U, Das D and Banerjee RK: Reactive oxygen species: Oxidative damage and pathogenesis. Current science. 658–666. 1999.

4 

Halliwell B: Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. Am J Med. 91:S14–S22. 1991. View Article : Google Scholar

5 

Betteridge DJ: What is oxidative stress? Metabolism. 49 2 Suppl 1:3–8. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Shukla V, Mishra SK and Pant HC: Oxidative stress in neurodegeneration. Adv Pharmacol Sci. 2011:5726342011.PubMed/NCBI

7 

Andersen JK: Oxidative stress in neurodegeneration: Cause or consequence? Nat Med. 10 Suppl:S18–S25. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Rodriguez-Rodriguez A, Egea-Guerrero JJ, Murillo-Cabezas F and Carrillo-Vico A: Oxidative stress in traumatic brain injury. Current Med Chem. 21:1201–1211. 2014. View Article : Google Scholar

9 

Giacco F and Brownlee M: Oxidative stress and diabetic complications. Circ Res. 107:1058–1070. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Asmat U, Abad K and Ismail K: Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 24:547–553. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Liochev SI: Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med. 60:1–4. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Mustafa AG, Al-Shboul O, Alfaqih MA, Al-Qudah MA and Al-Dwairi AN: Phenelzine reduces the oxidative damage induced by peroxynitrite in plasma lipids and proteins. Arch Physiol Biochem. 1–6. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Mustafa AG, Bani-Ahmad MA, Jaradat AQ and Allouh MZ: Tempol protects blood proteins and lipids against peroxynitrite-mediated oxidative damage. Exp Biol Med (Maywood). 240:109–112. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Mustafa AG, Singh IN, Wang J, Carrico KM and Hall ED: Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals. J Neurochem. 114:271–280. 2010.PubMed/NCBI

15 

Mylonas C and Kouretas D: Lipid peroxidation and tissue damage. In vivo. 13:295–309. 1999.PubMed/NCBI

16 

Jena NR: DNA damage by reactive species: Mechanisms, mutation and repair. J Biosci. 37:503–517. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Hemnani T and Parihar MS: Reactive oxygen species and oxidative DNA damage. Indian J Physiol Pharmacol. 42:440–452. 1998.PubMed/NCBI

18 

Suzuki YJ, Carini M and Butterfield DA: Protein Carbonylation. Antioxid Redox Signal. 12:323–325. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Ayala A, Muñoz MF and Argüelles S: Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-Hydroxy-2-Nonenal. Oxid Med Cell Longev. 2014:3604382014. View Article : Google Scholar : PubMed/NCBI

20 

Yin H, Xu L and Porter NA: Free radical lipid peroxidation: Mechanisms and analysis. Chem Rev. 111:5944–5972. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Girotti AW: Lipid hydroperoxide generation, turnover, and effector action in biological systems. J Lipid Res. 39:1529–1542. 1998.PubMed/NCBI

22 

Reis A and Spickett CM: Chemistry of phospholipid oxidation. Biochim Biophys Acta. 1818:2374–2387. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Dix TA and Aikens J: Mechanisms and biological relevance of lipid peroxidation initiation. Chem Res Toxicol. 6:2–18. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Zhong H and Yin H: Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria. Redox Biol. 4:193–199. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Schaur RJ, Siems W, Bresgen N and Eckl PM: 4-Hydroxy-nonenal-A bioactive lipid peroxidation product. Biomolecules. 5:2247–2337. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Yang Y, Sharma R, Sharma A, Awasthi S and Awasthi YC: Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim Pol. 50:319–336. 2003.PubMed/NCBI

27 

Jang EJ, Jeong HO, Park D, Kim DH, Choi YJ, Chung KW, Park MH, Yu BP and Chung HY: Src tyrosine kinase activation by 4-hydroxynonenal upregulates p38, ERK/AP-1 signaling and COX-2 expression in YPEN-1 Cells. PLoS One. 10:e01292442015. View Article : Google Scholar : PubMed/NCBI

28 

Cebak JE, Singh IN, Hill RL, Wang JA and Hall ED: Phenelzine protects brain mitochondrial function in vitro and in vivo following traumatic brain injury by scavenging the reactive carbonyls 4-hydroxynonenal and acrolein leading to cortical histological neuroprotection. J Neurotrauma. 34:1302–1317. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Jaganjac M, Tirosh O, Cohen G, Sasson S and Zarkovic N: Reactive aldehydes-second messengers of free radicals in diabetes mellitus. Free Radic Res. 47 Suppl 1:S39–S48. 2013. View Article : Google Scholar

30 

Hall ED, Braughler JM, Yonkers PA, Smith SL, Linseman KL, Means ED, Scherch HM, Von Voigtlander PF, Lahti RA and Jacobsen EJ: U-78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J Pharmacol Exp Ther. 258:688–694. 1991.PubMed/NCBI

31 

Raza H and John A: 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol Appl Pharmacol. 216:309–318. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Grimsrud PA, Xie H, Griffin TJ and Bernlohr DA: Oxidative stress and covalent modification of protein with bioactive aldehydes. J Biol Chem. 283:21837–21841. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Schieber M and Chandel NS: ROS function in redox signaling and oxidative stress. Curr Biol. 24:R453–R462. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Usatyuk PV and Natarajan V: Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cells. J Biol Chem. 279:11789–11797. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Huang Y, Li W and Kong AN: Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal. Cell Biosci. 2:402012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mustafa AG, Alfaqih MA and Al‑Shboul O: The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions. Exp Ther Med 16: 2132-2137, 2018.
APA
Mustafa, A.G., Alfaqih, M.A., & Al‑Shboul, O. (2018). The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions. Experimental and Therapeutic Medicine, 16, 2132-2137. https://doi.org/10.3892/etm.2018.6419
MLA
Mustafa, A. G., Alfaqih, M. A., Al‑Shboul, O."The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions". Experimental and Therapeutic Medicine 16.3 (2018): 2132-2137.
Chicago
Mustafa, A. G., Alfaqih, M. A., Al‑Shboul, O."The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2132-2137. https://doi.org/10.3892/etm.2018.6419
Copy and paste a formatted citation
x
Spandidos Publications style
Mustafa AG, Alfaqih MA and Al‑Shboul O: The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions. Exp Ther Med 16: 2132-2137, 2018.
APA
Mustafa, A.G., Alfaqih, M.A., & Al‑Shboul, O. (2018). The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions. Experimental and Therapeutic Medicine, 16, 2132-2137. https://doi.org/10.3892/etm.2018.6419
MLA
Mustafa, A. G., Alfaqih, M. A., Al‑Shboul, O."The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions". Experimental and Therapeutic Medicine 16.3 (2018): 2132-2137.
Chicago
Mustafa, A. G., Alfaqih, M. A., Al‑Shboul, O."The 4‑hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2132-2137. https://doi.org/10.3892/etm.2018.6419
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team