Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats

  • Authors:
    • Lei Luo
    • Zhang Zhou
    • Juan Xue
    • Yao Wang
    • Juan Zhang
    • Xin Cai
    • Yuqing Liu
    • Fan Yang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second People's Hospital of Yichang, Yichang, Hubei 443000, P.R. China, Department of Anesthesia, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Gastroenterology, Hubei Provincial Hospital of Traditional Chinese and Western Medicine, Wuhan, Hubei 430015, P.R. China, Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Pulmonary Diseases, Jingmen City Hospital of Traditional Chinese Medicine, Jingmen, Hubei 448000, P.R. China, School of Clinical Medical, Hubei University of Chinese Medicine, Wuhan, Hubei 430060, P.R. China, Department of Hepatology, Hubei Provincial Hospital of Chinese Medicine, Wuhan, Hubei 430074, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1715-1722
    |
    Published online on: July 9, 2018
       https://doi.org/10.3892/etm.2018.6430
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

It has been reported that intestinal epithelial barrier dysfunction serves an important role in the development of liver cirrhosis. However, at present there is no satisfactory treatment for intestinal mucosal lesions and ulcers associated with cirrhosis. The aim of the present study was to investigate the effect of Bletilla striata polysaccharide (BSP) on intestinal epithelial barrier disruption in rats with thioacetamide (TAA)‑induced liver cirrhosis. Rats were randomly divided into 5 groups (n=10): BSP low dosage (15 mg/kg), BSP middle dosage (30 mg/kg), BSP high dosage (60 mg/kg), experiment and control groups. All groups except control group were administered with TAA (200 mg/kg/day) to induce liver cirrhosis. Following modeling, rats in the low, middle and high‑dose BSP groups received BSP. ELISA kits were used to measure the endotoxin, alanine transaminase (ALT) and aspartate transaminase (AST) levels in the portal vein, while interleukin (IL)‑6 and tumor necrosis factor (TNF)‑α expression in the ileal tissue was measured. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting were used to detect the expression of zonula occludens (ZO)‑1 and occludin mRNA and protein, respectively. Intestinal epithelial tissue pathology was detected using hematoxylin‑eosin (HE) staining. Immunohistochemistry was performed to assess the expression of ZO‑1 and occludin in intestinal epithelial tissues. Following treatment with BSP, ALT, AST and endotoxin levels in the portal vein, as well as IL‑6 and TNF‑α expression in ileal tissues, were significantly decreased compared with model group (P<0.05 or 0.01). Furthermore, BSP treatment upregulated the expression of ZO‑1 and occludin mRNA and protein compared with the model group (P<0.05 or 0.01) and cytoplasmic staining for these proteins was increased. The degree of intestinal epithelial tissue pathological damage was significantly reduced in the BSP groups. In conclusion, BSP is able to reduce endotoxin levels, inhibit the inflammatory cytokines IL‑6 and TNF‑α and elevate expression of ZO‑1 and occludin at tight junctions. Together, these results suggest a novel protective agent for the restoration of intestinal epithelial barrier disruption.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Gogoi-Tiwari J, Köhn-Gaone J, Giles C, Schmidt-Arras D, Gratte ED, Elsegood CL, McCaughan GW, Ramm GA, Olynyk JK and Tirnitz-Parker JEE: The murine choline-deficient, ethionine-supplemented (CDE) diet model of chronic liver injury. J Vis Exp. Oct 21–2017. View Article : Google Scholar : PubMed/NCBI

2 

Wang H, Zhang W, Zuo L, Zhu W, Wang B, Li Q and Li J: Bifidobacteria may be beneficial to intestinal microbiota and reduction of bacterial translocation in mice following ischaemia and reperfusion injury. Br J Nutr. 109:1990–1998. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Arrieta MC, Bistritz L and Meddings JB: Alterations in intestinal permeability. Gut. 55:1512–1520. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Groschwitz KR and Hogan SP: Intestinal barrier function: Molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 124:3–20. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Turner JR: Intestinal mucosal barrier function in health and disease. Nat Rev Immunol. 9:799–809. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Clark JA, Doelle SM, Halpern MD, Saunders TA, Holubec H, Dvorak K, Boitano SA and Dvorak B: Intestinal barrier failure during experimental necrotizing enterocolitis: Protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol. 291:G938–G949. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Pijls KE, Koek GH, Elamin EE, de Vries H, Masclee AA and Jonkers DM: Large intestine permeability is increased in patients with compensated liver cirrhosis. Am J Physiol Gastrointest Liver Physiol. 306:G147–G153. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Andreasen AS, Krabbe KS, Krogh-Madsen R, Taudorf S, Pedersen BK and Moller K: Human endotoxemia as a model of systemic inflammation. Curr Med Chem. 15:1697–1705. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Marshall JC, Walker PM, Foster DM, Harris D, Ribeiro M, Paice J, Romaschin AD and Derzko AN: Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence. Crit Care. 6:342–348. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Yoshioka N, Taniguchi Y, Yoshida A, Nakata K, Nishizawa T, Inagawa H, Kohchi C and Soma G: Intestinal macrophages involved in the homeostasis of the intestine have the potential for responding to LPS. Anticancer Res. 29:4861–4865. 2009.PubMed/NCBI

11 

Cong X, Zhang Y, Yang NY, Li J, Ding C, Ding QW, Su YC, Mei M, Guo XH, Wu LL and Yu GY: Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland. J Cell Sci. 126:1109–1121. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Nolan JP: The role of intestinal endotoxin in liver injury: A long and evolving history. Hepatology. 52:1829–1835. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Trebicka J, Krag A, Gansweid S, Appenrodt B, Schiedermaier P, Sauerbruch T and Spengler U: Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt. Eur J Gastroenterol Hepatol. 23:1218–1225. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Adachi Y, Moore LE, Bradford BU, Gao W and Thurman RG: Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology. 108:218–224. 1995. View Article : Google Scholar : PubMed/NCBI

15 

Diao H, Li X, Chen J, Luo Y, Chen X, Dong L, Wang C, Zhang C and Zhang J: Bletilla striata polysaccharide stimulates inducilble nitric oxide synthase and proinflammatory cytokine expression in macrophages. J Biosci Bioeng. 105:85–89. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Wang C, Sun J, Luo Y, Xue W, Diao H, Dong L, Chen J and Zhang J: A polysaccaride isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro. Biotechnol Lett. 28:539–543. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Liu J, Li Q, Wang Y and Wang C: Two natural glucomannan polymers, from Konjac and Bletilla, as bioactive materials for pharmaceutical applications. Biotechnol Lett. 37:1–8. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Luo Y, Diao H, Xia S, Dong L, Chen J and Zhang J: A physiologically active polysaccharide hydrogel promotes wound healing. J Biomed Mater Res A. 94:193–204. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Dong L, Xia S, Luo Y, Diao H and Zhang J, Chen J and Zhang J: Targeting delivery oligonucleotide into macrophages by cationic polysaccharide from Bletilla striata successfully inhibited the expression of TNF-alpha. J Control Release. 134:214–220. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Y, Lv T, Li M, Xue T, Liu H, Zhang W, Ding X and Zhuang Z: Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag. 11:449–454. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Wang Y, Liu D, Chen S, Wang Y, Jiang H and Yin H: A new glucomannan from Bletilla striata: Structural and anti-fibrosis effects. Fitoterapia. 92:72–78. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Wang Y, Yang F, Xue J, Zhou X, Luo L, Ma Q, Chen YF, Zhang J, Zhang SL and Zhao L: Anti-schistosomiasis liverfibrosis effects of chlorogenic acid through IL-13/miR-21/Smad7 signaling interactions in vivo and in vitro. Antimicrob Agents Chemother. 61:pii: e01347. –16. 2017.

24 

Tsochatzis EA, Bosch J and Burroughs AK: Liver cirrhosis. Lancet. 383:1749–1761. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Malaguarnera G, Giordano M, Nunnari G, Bertino G and Malaguarnera M: Gut microbiota in alcoholic liver disease: Pathogenetic role and therapeutic perspectives. World J Gastroenterol. 20:16639–16648. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Brun P, Castagliuolo I, Di Leo V, Buda A, Pinzani M, Palù G and Martines D: Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol. 292:G518–G525. 2007.

27 

Caine WR, Metzler-Zebeli BU, McFall M, Miller B, Ward TL, Kirkwood RN and Mosenthin R: Supplementation of diets for gestating sows with zinc amino acid complex and gastric intubation of suckling pigs with zinc-methionine on mineral status, intestinal morphology and bacterial translocation in lipopolysaccharide-challenged early-weaned pigs. Res Vet Sci. 86:453–462. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Song HL, Lv S and Liu P: The roles of tumor necrosis factor-α in colon tight junction protein expression and intestinal mucosa structure in a mouse model of acute liver failure. BMC Gastroenterol. 9:702009. View Article : Google Scholar : PubMed/NCBI

29 

Yang DH, Ye ZY, Jin B, He XJ, Zhang Q, Zhou WM, Xu WJ and Lu HX: Salvianolate inhibits cytokine gene expression in small intestine of cirrhotic rats. World J Gastroenterol. 17:1903–1909. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Shen L, Weber CR, Raleigh DR, Yu D and Turner JR: Tight junction pore and leak pathways: A dynamic duo. Annu Rev Physiol. 73:283–309. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT and Turner JR: Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am J Pathol. 166:409–419. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Muñoz L, Borrero José M, Ubeda M, Lario M, Díaz D, Francés R, Monserrat J, Pastor O, Aguado-Fraile E, Such J, et al: Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis. Hepatology. 56:1861–1869. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Toda K, Kumagai N, Tsuchimoto K, Inagaki H, Suzuki T, Oishi T, Atsukawa K, Saito H, Morizane T, Hibi T and Ishii H: Induction of hepatic stellate cell proliferation by LPS-stimulated peripheral blood mononuclear cells from patients with liver cirrhosis. J Gastroenterol. 35:214–220. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Mitic LL, Van Itallie CM and Anderson JM: Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: Lessons from mutant animals and proteins. Am J Physiol Gastrointest Liver Physiol. 279:G250–G254. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Anderson JM and Van Itallie CM: Physiology and function of the tight junction. Cold Spring Harb Perspect Biol. 1:a0025842009. View Article : Google Scholar : PubMed/NCBI

36 

Gonzalez-Mariscal L, Betanzos A, Nava P and Jaramillo BE: Tight junction protein. Prog Biophys Mol Biol. 81:1–44. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Hu YJ, Wang YD, Tan FQ and Yang WX: Regulation of paracellular permeability: Factors and mechanisms. Mol Biol Rep. 40:6123–6142. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S and Tsukita S and Tsukita S: Occludin: A novel integral membrane protein localizing at tight junctions. J Cell Biol. 123:1777–1788. 1993. View Article : Google Scholar : PubMed/NCBI

39 

Saitou M, Ando-Akatsuka Y, Itoh M, Furuse M, Inazawa J, Fujimoto K and Tsukita S: Mammalian occludin in epithelial cells: Its expression and subcellular distribution. Eur J Cell Biol. 73:222–231. 1997.PubMed/NCBI

40 

Li J, Ge R, Zhao C, Tang L, Li J and Li Q: Farrerol regulates occludin expression in hydrogen peroxide-induced EA.hy926 cells by modulating ERK1/2 activity. Eur J Pharmacol. 734:9–14. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Chen D, Li L, Yan J, Yang X, You Y, Zhou Y and Ling X: The loss of αSNAP downregulates the expression of occludin in the intestinal epithelial cell of acute pancreatitis model. Pancreatology. 14:347–355. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Lapierre LA: The molecular structure of the tight junction. Adv Drug Deliv Rev. 41:255–264. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Berkes J, Viswanathan VK, Sarkovic SD and Hecht G: Intestinal epithelial responses to enteric pathogens: Effects on the tight junction barrier, ion transport, and inflammation. Gut. 52:439–451. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Beltinger J, McKaig BC, Makh S, Stack WA, Hawkey CJ and Mahida YR: Human colonic subepithelial myofibroblasts modulate transepithelial resistance and sceretory response. Am J Physiol. 277:C271–C279. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Stevenson BR, Siliciano JD, Mooseker MS and Goodenough DA: Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 103:755–766. 1986. View Article : Google Scholar : PubMed/NCBI

46 

Cario E, Gerken G and Podolsky DK: Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology. 127:224–238. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Chen J, Zhang R, Wang J, Yu P, Liu Q, Zeng D, Song H and Kuang Z: Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions. Can J Physiol Pharmacol. 93:233–237. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Luo L, Zhou Z, Xue J, Wang Y, Zhang J, Cai X, Liu Y and Yang F: Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats. Exp Ther Med 16: 1715-1722, 2018.
APA
Luo, L., Zhou, Z., Xue, J., Wang, Y., Zhang, J., Cai, X. ... Yang, F. (2018). Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats. Experimental and Therapeutic Medicine, 16, 1715-1722. https://doi.org/10.3892/etm.2018.6430
MLA
Luo, L., Zhou, Z., Xue, J., Wang, Y., Zhang, J., Cai, X., Liu, Y., Yang, F."Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats". Experimental and Therapeutic Medicine 16.3 (2018): 1715-1722.
Chicago
Luo, L., Zhou, Z., Xue, J., Wang, Y., Zhang, J., Cai, X., Liu, Y., Yang, F."Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1715-1722. https://doi.org/10.3892/etm.2018.6430
Copy and paste a formatted citation
x
Spandidos Publications style
Luo L, Zhou Z, Xue J, Wang Y, Zhang J, Cai X, Liu Y and Yang F: Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats. Exp Ther Med 16: 1715-1722, 2018.
APA
Luo, L., Zhou, Z., Xue, J., Wang, Y., Zhang, J., Cai, X. ... Yang, F. (2018). Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats. Experimental and Therapeutic Medicine, 16, 1715-1722. https://doi.org/10.3892/etm.2018.6430
MLA
Luo, L., Zhou, Z., Xue, J., Wang, Y., Zhang, J., Cai, X., Liu, Y., Yang, F."Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats". Experimental and Therapeutic Medicine 16.3 (2018): 1715-1722.
Chicago
Luo, L., Zhou, Z., Xue, J., Wang, Y., Zhang, J., Cai, X., Liu, Y., Yang, F."Bletilla striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1715-1722. https://doi.org/10.3892/etm.2018.6430
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team