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Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats

  • Authors:
    • Ying Liao
    • Kaihong Chen
    • Xingmo Dong
    • Weiguo Li
    • Ganyang Li
    • Guoyong Huang
    • Wei Song
    • Liling Chen
    • Yong Fang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Affiliated Longyan First Hospital of Fujian Medical University, Longyan, Fujian 364000, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2499-2505
    |
    Published online on: July 11, 2018
       https://doi.org/10.3892/etm.2018.6438
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Abstract

The effects of berberine on cardiac function of heart failure after myocardial infarction and its possible mechanism were investigated. The anterior descending branches of 50 female Wistar rats were ligatured to establish the model of heart failure after myocardial infarction. At 4 weeks after successful modeling, the rats were randomly divided into two groups receiving 4-week gavage with saline (Sal group) and berberine (Ber group), while the sham-operation group (Sham group) was set up. After 4 weeks, the hemodynamics and serum BNP in rats were measured. The hearts of rats were taken to detect the degree of myocardial fibrosis. The myocardial cell apoptosis was detected. The expressions and changes in myocardial apoptosis-related proteins, including Bcl-2, Bax and caspase-3, were detected. The expression and changes in GRP78, CHOP and caspase-12 in myocardial tissue were detected. The results showed that Berberine improved the cardiac function of rats after myocardial infarction. After myocardial infarction, myocardial fibrosis and apoptosis were observed around the infarction area, berberine improved the myocardial fibrosis and reduced cell apoptosis. Furthermore, berberine alleviated endoplasmic reticulum stress (ERS) after myocardial infarction. In conclusion, Berberine can inhibit the myocardium cell apoptosis of heart failure after myocardial infarction, and its mechanism may be realized by affecting the ERS in myocardial tissue of heart failure after myocardial infarction and CHOP and caspase-12 apoptotic signaling pathway, upregulating Bcl-2/Bax expression and downregulating caspase-3 expression, thus inhibiting the cardiac remodeling and protecting the cardiac function.
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Copy and paste a formatted citation
Spandidos Publications style
Liao Y, Chen K, Dong X, Li W, Li G, Huang G, Song W, Chen L and Fang Y: Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats. Exp Ther Med 16: 2499-2505, 2018.
APA
Liao, Y., Chen, K., Dong, X., Li, W., Li, G., Huang, G. ... Fang, Y. (2018). Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats. Experimental and Therapeutic Medicine, 16, 2499-2505. https://doi.org/10.3892/etm.2018.6438
MLA
Liao, Y., Chen, K., Dong, X., Li, W., Li, G., Huang, G., Song, W., Chen, L., Fang, Y."Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats". Experimental and Therapeutic Medicine 16.3 (2018): 2499-2505.
Chicago
Liao, Y., Chen, K., Dong, X., Li, W., Li, G., Huang, G., Song, W., Chen, L., Fang, Y."Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2499-2505. https://doi.org/10.3892/etm.2018.6438
Copy and paste a formatted citation
x
Spandidos Publications style
Liao Y, Chen K, Dong X, Li W, Li G, Huang G, Song W, Chen L and Fang Y: Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats. Exp Ther Med 16: 2499-2505, 2018.
APA
Liao, Y., Chen, K., Dong, X., Li, W., Li, G., Huang, G. ... Fang, Y. (2018). Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats. Experimental and Therapeutic Medicine, 16, 2499-2505. https://doi.org/10.3892/etm.2018.6438
MLA
Liao, Y., Chen, K., Dong, X., Li, W., Li, G., Huang, G., Song, W., Chen, L., Fang, Y."Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats". Experimental and Therapeutic Medicine 16.3 (2018): 2499-2505.
Chicago
Liao, Y., Chen, K., Dong, X., Li, W., Li, G., Huang, G., Song, W., Chen, L., Fang, Y."Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2499-2505. https://doi.org/10.3892/etm.2018.6438
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