Open Access

Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy

  • Authors:
    • Wei Liu
    • Jiangyi Yu
    • Qianhua Yan
    • Lijuan Wang
    • Nan Li
    • Wei Xiong
  • View Affiliations

  • Published online on: July 17, 2018     https://doi.org/10.3892/etm.2018.6449
  • Pages: 2545-2553
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of this meta‑analysis was to evaluate the evidence of the clinical efficacy and safety of sitagliptin in diabetic patients with incipient nephropathy. PubMed, Ovid, Cochrane library, Chinese National Knowledge Infrastructure, and Wanfang databases were searched in September 2017 to identify randomized controlled trials (RCTs) of sitagliptin in diabetic patients with incipient nephropathy. Study selection, data extraction and study quality assessment were performed independently by two investigators, while disagreements were resolved by a third reviewer. The treatment effect was estimated by calculating the mean difference (MD) or standard mean difference (SMD). Heterogeneity was assessed with the χ2 and I2 tests. Additionally, risk of bias graphs and summaries were used to assess the quality of the included trials. Thirteen RCTs were included in this review; their results suggested that sitagliptin has obvious advantages in lowering the 24‑hour urinary albumin excretion [MD, ‑25.71; 95% confidence interval (CI), ‑30.75 to ‑20.66; P<0.00001], serum cystatin C (MD, ‑0.59; 95% CI, ‑0.64 to ‑0.54; P<0.00001), inflammation (MD, ‑0.81; 95% CI, ‑1.20 to ‑0.42; P<0.0001), and total cholesterol (MD, ‑0.13; 95% CI, ‑0.22 to ‑0.03; P=0.009). However, sitagliptin did not appear to influence serum creatinine, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin A1c, or triglyceride levels, although these results may have been influenced by biases in the included trials. The most common adverse effects of sitagliptin were gastrointestinal tract reaction and hypoglycemia, although these symptoms resolved quickly. Sitagliptin appears to be effective in reducing proteinuria, ameliorating renal function, and producing an anti‑inflammatory effect in patients with early‑stage diabetic nephropathy. The present analysis provides important guidance for the clinical application of sitagliptin.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
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Spandidos Publications style
Liu W, Yu J, Yan Q, Wang L, Li N and Xiong W: Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy. Exp Ther Med 16: 2545-2553, 2018
APA
Liu, W., Yu, J., Yan, Q., Wang, L., Li, N., & Xiong, W. (2018). Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy. Experimental and Therapeutic Medicine, 16, 2545-2553. https://doi.org/10.3892/etm.2018.6449
MLA
Liu, W., Yu, J., Yan, Q., Wang, L., Li, N., Xiong, W."Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy". Experimental and Therapeutic Medicine 16.3 (2018): 2545-2553.
Chicago
Liu, W., Yu, J., Yan, Q., Wang, L., Li, N., Xiong, W."Meta‑analysis of the benefit of sitagliptin treatment in patients with type 2 diabetes complicated with incipient nephropathy". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2545-2553. https://doi.org/10.3892/etm.2018.6449