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Review

Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review)

  • Authors:
    • Nan Jiang
    • Jing‑Jing Lin
    • Jun Wang
    • Bei‑Ning Zhang
    • Ao Li
    • Zheng‑Yang Chen
    • Song Guo
    • Bin‑Bin Li
    • Yu‑Zhong Duan
    • Ru‑Yi Yan
    • Hong‑Feng Yan
    • Xiao‑Yan Fu
    • Jin‑Lian Zhou
    • He‑Ming Yang
    • Yan Cui
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, 306 Hospital of PLA, Beijing 100101, P.R. China, Department of Hepatology, 302 Teaching Hospital of Peking University Health Science Center, Beijing 100101, P.R. China, Department of General Surgery, PLA 306 Clinical Hospital of Anhui Medical University, Beijing 230000, P.R. China, Department of Pathology, 306 Hospital of PLA, Beijing 100101, P.R. China
  • Pages: 2183-2192
    |
    Published online on: July 17, 2018
       https://doi.org/10.3892/etm.2018.6459
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Abstract

Human epidermal growth factor receptor‑2 positive breast cancer (HER2+ BC) is characterized by a high rate of metastasis and drug resistance. The advent of targeted therapy drugs greatly improves the prognosis of HER2+ BC patients. However, drug resistance or severe side effects have limited the application of targeted therapy drugs. To achieve more effective treatment, considerable research has concentrated on strategies to overcome drug resistance. Abemaciclib (CDK4/6 inhibitor), a new antibody‑drug conjugate (ADC), src homology 2 (SH2) containing tyrosine phosphatase‑1 (SHP‑1) and fatty acid synthase (FASN) have been demonstrated to improve drug resistance. In addition, using an effective vector to accurately deliver drugs to tumors has shown good application prospects. Many studies have also found that natural anti‑cancer substances produced effective results during in vitro and in vivo anti‑HER2+ BC research. This review aimed to summarize the current status of potential clinical drugs that may benefit HER2+ BC patients in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang N, Lin JJ, Wang J, Zhang BN, Li A, Chen ZY, Guo S, Li BB, Duan YZ, Yan RY, Yan RY, et al: Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review). Exp Ther Med 16: 2183-2192, 2018.
APA
Jiang, N., Lin, J., Wang, J., Zhang, B., Li, A., Chen, Z. ... Cui, Y. (2018). Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review). Experimental and Therapeutic Medicine, 16, 2183-2192. https://doi.org/10.3892/etm.2018.6459
MLA
Jiang, N., Lin, J., Wang, J., Zhang, B., Li, A., Chen, Z., Guo, S., Li, B., Duan, Y., Yan, R., Yan, H., Fu, X., Zhou, J., Yang, H., Cui, Y."Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review)". Experimental and Therapeutic Medicine 16.3 (2018): 2183-2192.
Chicago
Jiang, N., Lin, J., Wang, J., Zhang, B., Li, A., Chen, Z., Guo, S., Li, B., Duan, Y., Yan, R., Yan, H., Fu, X., Zhou, J., Yang, H., Cui, Y."Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review)". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2183-2192. https://doi.org/10.3892/etm.2018.6459
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang N, Lin JJ, Wang J, Zhang BN, Li A, Chen ZY, Guo S, Li BB, Duan YZ, Yan RY, Yan RY, et al: Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review). Exp Ther Med 16: 2183-2192, 2018.
APA
Jiang, N., Lin, J., Wang, J., Zhang, B., Li, A., Chen, Z. ... Cui, Y. (2018). Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review). Experimental and Therapeutic Medicine, 16, 2183-2192. https://doi.org/10.3892/etm.2018.6459
MLA
Jiang, N., Lin, J., Wang, J., Zhang, B., Li, A., Chen, Z., Guo, S., Li, B., Duan, Y., Yan, R., Yan, H., Fu, X., Zhou, J., Yang, H., Cui, Y."Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review)". Experimental and Therapeutic Medicine 16.3 (2018): 2183-2192.
Chicago
Jiang, N., Lin, J., Wang, J., Zhang, B., Li, A., Chen, Z., Guo, S., Li, B., Duan, Y., Yan, R., Yan, H., Fu, X., Zhou, J., Yang, H., Cui, Y."Novel treatment strategies for patients with HER2‑positive breast cancer who do not benefit from current targeted therapy drugs (Review)". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2183-2192. https://doi.org/10.3892/etm.2018.6459
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