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Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis

  • Authors:
    • Changliang Wu
    • Liyu Guan
    • Li Yao
    • Jiean Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2319-2324
    |
    Published online on: July 18, 2018
       https://doi.org/10.3892/etm.2018.6464
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Abstract

The aim of the present study was to investigate the safety and efficacy of mesalazine suppository in the treatment of refractory ulcerative chronic radiation proctitis (CRP). In total, 10 refractory ulcerative CRP patients who did not respond to previous medical treatments were recruited for the present study and were treated with mesalazine suppository (0.5 g) twice daily for 24 weeks. For each patient, the severity of clinical symptoms and endoscopic appearance was assessed before and after the treatment. For symptom scoring, the reductions in the mean total symptom score (pre‑ vs. post‑treatment, 8.20 vs. 0.90; P<0.01), rectal bleeding score (2.40 vs. 0.30; P<0.01), rectal pain score (2.00 vs. 0.50; P<0.01), stool frequency score (2.00 vs. 0.10; P<0.01) and tenesmus score (1.80 vs. 0.00; P<0.01) were all statistically significant. For mucosal damage scoring, there was a reduction in the mean scores for total scores (9.22 vs. 5.22; P<0.01), telangiectasia (2.78 vs. 1.89; P=0.009), edema (2.89 vs. 1.78; P=0.001) and ulceration (2.44 vs. 0.89; P=0.003). However, statistically reductions in the median symptom scores were not observed for stenosis (0.78 vs. 0.67; P=0.347) and necrosis (0.33 vs. 0.00; P=0.081). Furthermore, no adverse events were observed during and after the treatment. The topical mesalazine suppository may be a safe and effective treatment for CRP, particularly for patients with deep ulcers. Adequately randomized controlled trials are required to confirm the results of the present study.
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Copy and paste a formatted citation
Spandidos Publications style
Wu C, Guan L, Yao L and Huang J: Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis. Exp Ther Med 16: 2319-2324, 2018.
APA
Wu, C., Guan, L., Yao, L., & Huang, J. (2018). Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis. Experimental and Therapeutic Medicine, 16, 2319-2324. https://doi.org/10.3892/etm.2018.6464
MLA
Wu, C., Guan, L., Yao, L., Huang, J."Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis". Experimental and Therapeutic Medicine 16.3 (2018): 2319-2324.
Chicago
Wu, C., Guan, L., Yao, L., Huang, J."Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2319-2324. https://doi.org/10.3892/etm.2018.6464
Copy and paste a formatted citation
x
Spandidos Publications style
Wu C, Guan L, Yao L and Huang J: Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis. Exp Ther Med 16: 2319-2324, 2018.
APA
Wu, C., Guan, L., Yao, L., & Huang, J. (2018). Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis. Experimental and Therapeutic Medicine, 16, 2319-2324. https://doi.org/10.3892/etm.2018.6464
MLA
Wu, C., Guan, L., Yao, L., Huang, J."Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis". Experimental and Therapeutic Medicine 16.3 (2018): 2319-2324.
Chicago
Wu, C., Guan, L., Yao, L., Huang, J."Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2319-2324. https://doi.org/10.3892/etm.2018.6464
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