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Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma

  • Authors:
    • Jie Zeng
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    Affiliations: Department of Emergency Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2478-2482
    |
    Published online on: July 18, 2018
       https://doi.org/10.3892/etm.2018.6472
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Abstract

The aim of this study was to analyze the dynamic changes and predictive values of nuclear factor-κB (NF-κB) combined with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in peripheral blood in multiple organ dysfunction syndrome (MODS) in patients with severe multiple trauma. Seventy patients diagnosed with severe multiple trauma in Emergency Department of Sichuan Provincial People's Hospital (Chengdu, China) from April 2014 to April 2016 were selected and retrospectively analyzed. The patients enrolled were divided into the MODS group (n=25) and the non-MODS group (n=45). The injury severity scores (ISSs), acute physiology and chronic health evaluation II (APACHE II) scores, NF-κB, IL-6 and TNF-α levels in patients were detected at different time points (12, 24 and 48 h after admission), the changes in different indexes and the areas under the receiver operating characteristic (ROC) curve (AUC) were analyzed. The predictive values of different detection methods in MODS patients were discussed and compared. The ISS, APACHE II score, NF-κB, IL-6 and TNF-α levels in the MODS group at admission and 24 and 48 h after admission were higher than those in the non-MODS group (P<0.05). Those indexes in the deceased patients at 12, 24 and 48 h after admission were higher than those in survivors (P<0.05). The ISS, APACHE II score, NF-κB, IL-6 and TNF-α levels were not the risk factors of MODS in patients with severe multiple trauma (P>0.05). AUCs of ISS >22 points and APACHE II score >14 points in predicting MODS were lower than that of combined detection of NF-κB >1.20. In conclusion, the combined detection of NF-κB, IL-6 and TNF-α in peripheral blood of patients with acute multiple trauma is more helpful to predict the occurrence of MODS, which has a certain guiding significance for the prognosis of patients with MODS.
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1 

Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, et al: Acute lung injury in patients with traumatic injuries: Utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma. 68:1121–1127. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Davenport R and Brohi K: Fibrinogen depletion in trauma: Early, easy to estimate and central to trauma-induced coagulopathy. Crit Care. 17:1902013. View Article : Google Scholar : PubMed/NCBI

3 

Frink M, van Griensven M, Kobbe P, Brin T, Zeckey C, Vaske B, Krettek C and Hildebrand F: IL-6 predicts organ dysfunction and mortality in patients with multiple injuries. Scand J Trauma Resusc Emerg Med. 17:492009. View Article : Google Scholar : PubMed/NCBI

4 

Matsuda N, Hattori Y, Takahashi Y, Nishihira J, Jesmin S, Kobayashi M and Gando S: Therapeutic effect of in vivo transfection of transcription factor decoy to NF-kappaB on septic lung in mice. Am J Physiol Lung Cell Mol Physiol. 287:L1248–L1255. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Moraes LA, Piqueras L and Bishop-Bailey D: Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther. 110:371–385. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Maffia P, Patel NS, Di Paola R, Ialenti A, Genovese T, Chatterjee PK, et al: Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. Eur J Pharmacol. 483:79–93. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL and Sibbald WJ: Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med. 23:1638–1652. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Damiani P and Burini G: Fluorometric determination of nitrite. Talanta. 33:649–652. 1986. View Article : Google Scholar : PubMed/NCBI

9 

Dougnac A, Riquelme A, Calvo M, Andresen M, Magedzo A, Eugenin E, Marshall G and Gutiérrez M: Study of cytokines kinetics in severe sepsis and its relationship with mortality and score of organic dysfunction. Rev Med Chil. 129:347–358. 2001.(In Spanish). PubMed/NCBI

10 

Stegmaier J, Kirchhoff C, Kanz KG, Mayer V, Landes J, Euler E, Mutschler W and Biberthaler P: Analysis of NF-kappaB nuclear translocation in PMN-neutrophils of major trauma patients in the early post-traumatic period: A pilot study. World J Surg. 30:2142–2151. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Zhao E, Wang L and Wen Q: Fasudil hydrochloride differentiates bone marrow mesenchymal stem cells into neurons via notch signaling. Neural Regen Res. 5:814–819. 2010.

12 

Pacary E, Legros H, Valable S, Duchatelle P, Lecocq M, Petit E, Nicole O and Bernaudin M: Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells. J Cell Sci. 119:2667–2678. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Pacary E, Petit E and Bernaudin M: Concomitant inhibition of prolyl hydroxylases and ROCK initiates differentiation of mesenchymal stem cells and PC12 towards the neuronal lineage. Biochem Biophys Res Commun. 377:400–406. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS and Vignali DA: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 450:566–569. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Neunaber C, Zeckey C, Andruszkow H, Frink M, Mommsen P, Krettek C and Hildebrand F: Immunomodulation in polytrauma and polymicrobial sepsis - where do we stand? Recent Pat Inflamm Allergy Drug Discov. 5:17–25. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Marti L, Cervera C, Filella X, Marin JL, Almela M and Moreno A: Cytokine-release patterns in elderly patients with systemic inflammatory response syndrome. Gerontology. 53:239–244. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Li J, Li NP, Gu YF, Yang X, Lu XB, Cong JN, Ling Y, Tang JA, Yuan XY and Wang H: Dynamic activity of NF-kappaB in multiple trauma patients and protective effects of ulinastain. Chin J Traumatol. 14:354–358. 2011.PubMed/NCBI

18 

Yadav K, Zehtabchi S, Nemes PC, Miller AC, Azher M, Durkin H and Sinert R: Early immunologic responses to trauma in the emergency department patients with major injuries. Resuscitation. 80:83–88. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Shih HC, Huang MS and Lee CH: Polymorphonuclear cell priming associated with NF-κB activation in patients with severe injury is partially dependent on macrophage migration inhibitory factor. J Am Coll Surg. 211:791–797. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Li R, Zijlstra JG, Kamps JA, van Meurs M and Molema G: Abrupt reflow enhances cytokine-induced proinflammatory activation of endothelial cells during simulated shock and resuscitation. Shock. 42:356–364. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zeng J: Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma. Exp Ther Med 16: 2478-2482, 2018.
APA
Zeng, J. (2018). Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma. Experimental and Therapeutic Medicine, 16, 2478-2482. https://doi.org/10.3892/etm.2018.6472
MLA
Zeng, J."Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma". Experimental and Therapeutic Medicine 16.3 (2018): 2478-2482.
Chicago
Zeng, J."Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2478-2482. https://doi.org/10.3892/etm.2018.6472
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng J: Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma. Exp Ther Med 16: 2478-2482, 2018.
APA
Zeng, J. (2018). Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma. Experimental and Therapeutic Medicine, 16, 2478-2482. https://doi.org/10.3892/etm.2018.6472
MLA
Zeng, J."Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma". Experimental and Therapeutic Medicine 16.3 (2018): 2478-2482.
Chicago
Zeng, J."Values of detection of NF-κB activation level combined with IL-6 and TNF-α levels in peripheral neutrophils in the prediction of multiple organ dysfunction syndrome in patients with severe multiple trauma". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2478-2482. https://doi.org/10.3892/etm.2018.6472
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