Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3

  • Authors:
    • Jing Zhang
    • Shengze Li
    • Yanhua Li
    • Hongli Liu
    • Yuan Zhang
    • Qingsong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2433-2441
    |
    Published online on: July 20, 2018
       https://doi.org/10.3892/etm.2018.6491
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cervical cancer (CC) is one of the most malignant tumors that affect women. Recent studies have reported that microRNAs (miRs) serve important roles in CC. The aim of the present study was to investigate the role of miR‑218 in CC and to verify its underlying mechanism. The results of reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) revealed that miR‑218 was dramatically downregulated in CC tissues and cell lines. Furthermore, the expression of Gli3 and Ki67 was measured using RT‑qPCR and the results revealed that levels of these proteins were negatively correlated with miR‑218 in CC tissues. The protein expression levels were determined by western blotting. Then SiHa cell line was used to investigate the mechanism of CC. Following cell transfection, cell apoptosis and cycle analyses were performed using the flow cytometry. The results revealed that miR‑218 overexpression significantly inhibited cell proliferation, apoptosis and cell cycle. Additionally, luciferase reporter assay revealed that Gli3 may be a novel and direct target of miR‑218 in CC. Taken together, the results of the present study suggest that miR‑218 overexpression or Gli3 knockdown may have potential as therapeutic strategies for the treatment of CC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lahue BJ, Baginska E, Li SS and Parisi M: Health technology assessment on cervical cancer screening 2000–2014. Int J Technol Assess Health Care. 31:171–180. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Subramanian S, Trogdon J, Ekwueme DU, Gardner JG, Whitmire JT and Rao C: Cost of cervical cancer treatment: Implications for providing coverage to low-income women under the Medicaid expansion for cancer care. Womens Health Issues. 20:400–405. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Arbyn M, Castellsague X, de Sanjose S, Bruni L, Saraiya M, Bray F and Ferlay J: Worldwide burden of cervical cancer in 2008. Ann Oncol. 22:2675–2686. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Gómez-Gómez Y, Organista-Nava J and Gariglio P: Deregulation of the miRNAs expression in cervical cancer: Human papillomavirus implications. Biomed Res Int 2013. 4070522013.

6 

Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D and Woo S: A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish. Development. 138:1409–1419. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Alajez NM, Lenarduzzi M, Ito E, Hui AB, Shi W, Bruce J, Yue S, Huang SH, Xu W, Waldron J, et al: miR-218 suppresses nasopharyngeal cancer progression through downregulation of surviving and SLIT2-ROBO1 pathway. Cancer Res. 71:2381–2391. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Small EM, Sutherland LB, Rajagopalan KN, Wang S and Olson EN: MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling. Circ Res. 107:1336–1344. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Zhao H, Anand AR and Ganju RK: Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia. J Immunol. 192:385–393. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Dickinson RE, Dallol A, Bieche I, Krex D, Morton D, Maher ER and Latif F: Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers. Br J Cancer. 91:2071–2078. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Narayan G, Goparaju C, Arias-Pulido H, Kaufmann AM, Schneider A, Dürst M, Mansukhani M, Pothuri B and Murty VV: Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. Mol Cancer. 5:162006. View Article : Google Scholar : PubMed/NCBI

12 

Dallol A, Morton D, Maher ER and Latif F: SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. Cancer Res. 63:1054–1058. 2003.PubMed/NCBI

13 

Xin SY, Feng XS, Zhou LQ, Sun JJ, Gao XL and Yao GL: Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis. World J Gastroenterol. 20:6906–6911. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Ding H, Wu YL, Wang YX and Zhu FF: Characterization of the MicroRNA expression profile of cervical squamous cell carcinoma metastases. Asian Pac J Cancer Prev. 15:1675–1679. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Zheng ZM and Wang X: Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta. 1809:668–677. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Rao Q, Shen Q, Zhou H, Peng Y, Li J and Lin Z: Aberrant microRNA expression in human cervical carcinomas. Med Oncol. 29:1242–1248. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yamamoto N, Kinoshita T, Nohata N, Itesako T, Yoshino H, Enokida H, Nakagawa M, Shozu M and Seki N: Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma. Int J Oncol. 42:1523–1532. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Lee H, Kim KR, Cho NH, Hong SR, Jeong H, Kwon SY, Park KH, An HJ, Kim TH, Kim I, et al: MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix. World J Surg Oncol. 12:3342014. View Article : Google Scholar : PubMed/NCBI

19 

Banno K, Iida M, Yanokura M, Kisu I, Iwata T, Tominaga E, Tanaka K and Aoki D: MicroRNA in cervical cancer: OncomiRs and tumor suppressor miRs in diagnosis and treatment. ScientificWorldJournal. 2014:1780752014. View Article : Google Scholar : PubMed/NCBI

20 

Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP and Khan SA: Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 27:2575–2582. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Uesugi A, Kozaki K, Tsuruta T, Furuta M, Morita K, Imoto I, Omura K and Inazawa J: The tumor suppressive microRNA miR-218 targets the mTOR component rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res. 71:5765–5778. 2011. View Article : Google Scholar : PubMed/NCBI

22 

He H, Di Y, Liang M, Yang F, Yao L, Hao S, Li J, Jiang Y, Jin C and Fu D: The microRNA-218 and ROBO-1 signaling axis correlates with the lymphatic metastasis of pancreatic cancer. Oncol Rep. 30:651–658. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yang M, Liu R, Sheng J, Liao J, Wang Y, Pan E, Guo W, Pu Y and Yin L: Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma. Oncol Rep. 29:169–176. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Tu K, Li C, Zheng X, Yang W, Yao Y and Liu Q: Prognostic significance of miR-218 in human hepatocellular carcinoma and its role in cell growth. Oncol Rep. 32:1571–1577. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Bai XY, Lin JY, Zhang XC, Xie Z, Yan HH, Chen ZH, Xu CR, An SJ, Sheng GM and Wu YL: High expression of truncated GLI3 is associated with poor overall survival in patients with non-small cell lung cancer. Cancer Biomark. 13:37–47. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancerincidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Dappa E, Elger T, Hasenburg A, Düber C, Battista MJ and Hötker AM: The value of advanced MRI techniques in the assessment of cervical cancer: A review. Insights Imaging. 8:471–481. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Wang HY, Kim G, Cho H, Kim S, Lee D, Park S, Park KH and Lee H: Diagnostic performance of HPV E6/E7, hTERT, and Ki67 mRNA RT-qPCR assays on formalin-fixed paraffin-embedded cervical tissue specimens from women with cervical cancer. Exp Mol Pathol. 98:510–516. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, Saraiya M, Bray F and Ferlay J: Worldwide burden of cervical cancer in 2008. Ann Oncol. 22:2675–2686. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Luo Q, Zhang S, Wei H, Pang X and Zhang H: Roles of Foxp3 in the occurrence and development of cervical cancer. Int J Clin Exp Pathol. 8:8717–8730. 2015.PubMed/NCBI

32 

Burd EM: Human papillomavirus and cervical cancer. Clin Microbiol Rev. 16:1–17. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Nour NM: Cervical cancer: A preventable death. Rev Obstet Gynecol. 2:240–244. 2009.PubMed/NCBI

34 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:1–866. 2006. View Article : Google Scholar

35 

Kogo R, How C, Chaudary N, Bruce J, Shi W, Hill RP, Zahedi P, Yip KW and Liu FF: The microRNA-218~survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget. 6:1090–1100. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Yu J, Wang Y, Dong R, Huang X, Ding S and Qiu H: Circulating MicroRNA-218 was reduced in cervical cancer and correlated with tumor invasion. J Cancer Res Clin Oncol. 138:671–674. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Yuan W, Xiaoyun H, Haifeng Q, Jing L, Weixu H, Ruofan D, Jinjin Y and Zongji S: MicroRNA-218 enhances the radiosensitivity of human cervical cancer via promoting radiation induced apoptosis. Int J Med Sci. 11:691–696. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Hartono D, Lioe B, Zhang Y, Li B and Yu J: Impacts of particulate matter (PM2.5) on the behavior of freshwater snail Parafossarulus striatulus. Sci Rep. 7:6442017. View Article : Google Scholar : PubMed/NCBI

39 

Tang BB, Liu SY, Zhang YU, Wei LQ, Mao XL, Wang J, Li LI and Lu ZX: microRNA-218 expression and its association with the clinicopathological characteristics of patients with cervical cancer. Exp Ther Med. 10:269–274. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Steg A, Amm HM, Novak Z, Frost AR and Johnson MR: Gli3 mediates cell survival and sensitivity to cyclopamine in pancreaticcancer. Cancer Biol Ther. 10:893–902. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Iwasaki H, Nakano K, Shinkai K, Kunisawa Y, Hirahashi M, Oda Y, Onishi H and Katano M: Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes. Cancer Sci. 104:328–336. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Kang HN, Oh SC, Kim JS and Yoo YA: Abrogation of Gli3 expression suppresses the growth of colon cancercells via activation of p53. Exp Cell Res. 318:539–549. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Li S, Li Y, Liu H, Zhang Y and Zhang Q: miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3. Exp Ther Med 16: 2433-2441, 2018.
APA
Zhang, J., Li, S., Li, Y., Liu, H., Zhang, Y., & Zhang, Q. (2018). miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3. Experimental and Therapeutic Medicine, 16, 2433-2441. https://doi.org/10.3892/etm.2018.6491
MLA
Zhang, J., Li, S., Li, Y., Liu, H., Zhang, Y., Zhang, Q."miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3". Experimental and Therapeutic Medicine 16.3 (2018): 2433-2441.
Chicago
Zhang, J., Li, S., Li, Y., Liu, H., Zhang, Y., Zhang, Q."miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2433-2441. https://doi.org/10.3892/etm.2018.6491
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Li S, Li Y, Liu H, Zhang Y and Zhang Q: miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3. Exp Ther Med 16: 2433-2441, 2018.
APA
Zhang, J., Li, S., Li, Y., Liu, H., Zhang, Y., & Zhang, Q. (2018). miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3. Experimental and Therapeutic Medicine, 16, 2433-2441. https://doi.org/10.3892/etm.2018.6491
MLA
Zhang, J., Li, S., Li, Y., Liu, H., Zhang, Y., Zhang, Q."miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3". Experimental and Therapeutic Medicine 16.3 (2018): 2433-2441.
Chicago
Zhang, J., Li, S., Li, Y., Liu, H., Zhang, Y., Zhang, Q."miRNA‑218 regulates the proliferation and apoptosis of cervical cancer cells via targeting Gli3". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2433-2441. https://doi.org/10.3892/etm.2018.6491
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team