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Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials

  • Authors:
    • Zhi‑Peng Wu
    • Pei Zhang
    • Jian‑Zhong Bai
    • Yuan Liang
    • Jin‑Shan He
    • Jing‑Cheng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Orthopedics, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Orthopedics, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2449-2459
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    Published online on: July 20, 2018
       https://doi.org/10.3892/etm.2018.6495
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Abstract

The purpose of the present meta‑analysis was to assess the efficacy and safety of baricitinib for active rheumatoid arthritis (RA) in patients with an inadequate response or intolerance to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs (DMARDs). A total of 7 randomized controlled trials (RCTs) were included. The primary effective outcome was the RA improvement to reach an American College of Rheumatology 20% (ACR20) response rate. The safety outcomes were composed of clinical laboratory parameters. All patients included received 4 mg baricitinib once daily to treat RA for 12 or 24 weeks. The ACR20 response rate in the baricitinib group was significantly higher compared with that in the control group at 12 weeks [relative risk (RR), 1.77; 95% confidence interval (CI), 1.62‑1.94; P<0.00001] and 24 weeks (RR, 1.76; 95% CI, 1.48‑2.10; P<0.00001). Similarly, other effective outcome measures also exhibited significant improvements in the baricitinib group compared with those in the placebo group. Regarding the safety outcomes, no significant difference in adverse events (AEs) was identified at 12 weeks (P=0.14), but AEs were significantly higher in the baricitinib group compared with those in the control group at 24 weeks (P=0.03). Most laboratory values were significantly different between the baricitinib and placebo groups; however, the clinical significance of these changes remains to be determined. In summary, the present meta‑analysis demonstrated that 4 mg baricitinib once daily was beneficial in patients with active RA with an inadequate response or intolerance to conventional synthetic or biological DMARDs. More high‑quality RCTs are required to determine the sustained efficacy and the safety of baricitinib.
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Copy and paste a formatted citation
Spandidos Publications style
Wu ZP, Zhang P, Bai JZ, Liang Y, He JS and Wang JC: Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials. Exp Ther Med 16: 2449-2459, 2018.
APA
Wu, Z., Zhang, P., Bai, J., Liang, Y., He, J., & Wang, J. (2018). Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 16, 2449-2459. https://doi.org/10.3892/etm.2018.6495
MLA
Wu, Z., Zhang, P., Bai, J., Liang, Y., He, J., Wang, J."Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 16.3 (2018): 2449-2459.
Chicago
Wu, Z., Zhang, P., Bai, J., Liang, Y., He, J., Wang, J."Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2449-2459. https://doi.org/10.3892/etm.2018.6495
Copy and paste a formatted citation
x
Spandidos Publications style
Wu ZP, Zhang P, Bai JZ, Liang Y, He JS and Wang JC: Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials. Exp Ther Med 16: 2449-2459, 2018.
APA
Wu, Z., Zhang, P., Bai, J., Liang, Y., He, J., & Wang, J. (2018). Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials. Experimental and Therapeutic Medicine, 16, 2449-2459. https://doi.org/10.3892/etm.2018.6495
MLA
Wu, Z., Zhang, P., Bai, J., Liang, Y., He, J., Wang, J."Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 16.3 (2018): 2449-2459.
Chicago
Wu, Z., Zhang, P., Bai, J., Liang, Y., He, J., Wang, J."Efficacy and safety of baricitinib for active rheumatoid arthritis in patients with an inadequate response to conventional synthetic or biological disease‑modifying anti‑rheumatic drugs: A meta‑analysis of randomized controlled trials". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2449-2459. https://doi.org/10.3892/etm.2018.6495
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