Acetylpuerarin inhibits oxygen‑glucose deprivation‑induced neuroinflammation of rat primary astrocytes via the suppression of HIF‑1 signaling

  • Authors:
    • Yanxiao Xiang
    • Pengchao Du
    • Xiumei Zhang
    • Siddhartha Biswas
    • Guangjun Jiao
    • Haichun Liu
  • View Affiliations

  • Published online on: July 23, 2018     https://doi.org/10.3892/etm.2018.6509
  • Pages: 2689-2695
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Abstract

In the central nervous system (CNS), ischemic injury induced by inflammation associated with astrocytes serves an important role in physiological and pathological processes. Neuroinflammation leads to the release of pro‑inflammatory cytokines, including tumor necrosis factor‑α and interleukin‑1β. The aim of the present study was to investigate whether acetylpuerarin attenuates oxygen‑glucose deprivation (OGD)‑induced astrocyte inflammation and secretion of pro‑inflammatory cytokines via inhibiting hypoxia‑inducible factor‑1 (HIF‑1) activation and suppressing downstream primary astrocyte signaling in rats. The results demonstrated that acetylpuerarin attenuates astrocyte viability and induces morphological changes following OGD stress. Furthermore, acetylpuerarin suppresses the stimulation of HIF‑1α and nuclear factor (NF)‑κB signaling pathways, while attenuating the expression and secretion of pro‑inflammatory cytokines via HIF‑1 suppression in OGD‑induced astrocytes. These findings indicate that acetylpuerarin may attenuate OGD‑induced astrocyte damage and inflammation in rat primary astrocytes via suppressing HIF‑1 activation and NF‑κB signaling. These results suggest that acetylpuerarin regulates inflammation associated with astrocytes and may represent a novel therapeutic agent for the treatment of neuroinflammation in the CNS.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xiang Y, Du P, Zhang X, Biswas S, Jiao G and Liu H: Acetylpuerarin inhibits oxygen‑glucose deprivation‑induced neuroinflammation of rat primary astrocytes via the suppression of HIF‑1 signaling. Exp Ther Med 16: 2689-2695, 2018
APA
Xiang, Y., Du, P., Zhang, X., Biswas, S., Jiao, G., & Liu, H. (2018). Acetylpuerarin inhibits oxygen‑glucose deprivation‑induced neuroinflammation of rat primary astrocytes via the suppression of HIF‑1 signaling. Experimental and Therapeutic Medicine, 16, 2689-2695. https://doi.org/10.3892/etm.2018.6509
MLA
Xiang, Y., Du, P., Zhang, X., Biswas, S., Jiao, G., Liu, H."Acetylpuerarin inhibits oxygen‑glucose deprivation‑induced neuroinflammation of rat primary astrocytes via the suppression of HIF‑1 signaling". Experimental and Therapeutic Medicine 16.3 (2018): 2689-2695.
Chicago
Xiang, Y., Du, P., Zhang, X., Biswas, S., Jiao, G., Liu, H."Acetylpuerarin inhibits oxygen‑glucose deprivation‑induced neuroinflammation of rat primary astrocytes via the suppression of HIF‑1 signaling". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2689-2695. https://doi.org/10.3892/etm.2018.6509