Values of serum LDL and PCT levels in evaluating the condition and prognosis of acute cerebral infarction

Meng,Xianliang; Wen,Renying; Li,Xiao

doi:10.3892/etm.2018.6522

Values of serum LDL and PCT levels in evaluating the condition and prognosis of acute cerebral infarction

Authors:
- Xianliang Meng
- Renying Wen
- Xiao Li
View Affiliations

Affiliations: Department of Neurology, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Internal Medicine, People's Hospital of Huimin County, Binzhou, Shandong 251700, P.R. China, Department of Rehabilitation, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China
Published online on: July 25, 2018 https://doi.org/10.3892/etm.2018.6522
Pages: 3065-3069

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Values of low density lipoprotein (LDL) and procalcitonin (PCT) levels in evaluating the condition and prognosis of patients with acute cerebral infarction (ACI) were investigated. According to the volume of cerebral infarction, 150 patients with ACI (observation group) were divided into the mild infarction group (n=50), moderate infarction group (n=50), and severe infarction group (n=50). Besides, another 50 healthy subjects were enrolled during the same period as the control group. The levels of serum LDL and PCT on admission and at the 1st, 3rd, 7th and 10th day after treatment were detected, which were compared with those in the control group. Ten days after treatment, patients were divided into two groups, the effective group and non-effective group, based on the clinical efficacy. The differences in LDL and PCT levels were compared between the two groups. After 1 month, the clinical efficacy was evaluated again, and the correlations of LDL and PCT levels with prognosis were analyzed. The levels of serum LDL and PCT in the observation group 1 day after admission were higher than those in the control group (P<0.05), which reached the peak at the 3rd day and continuously declined after the 7th day. The LDL and PCT levels had statistically significant differences between the effective group and non-effective group (P<0.05). Pearson's correlation analysis showed that the serum LDL and PCT levels in acute phase were negatively correlated with the National Institutes of Health Stroke Scale (NIHSS) score after 1 month of treatment (P<0.05). The dynamic monitoring of serum LDL and PCT levels in ACI patients can help evaluate the condition and prognosis of patients.

View Figures

View References

1	Camerlingo M, Valente L, Tognozzi M, Beretta GL, Moschini L and Cesana BM: C-reactive protein levels in the first three hours after acute cerebral infarction. Int J Neurosci. 121:65–68. 2011. View Article : Google Scholar : PubMed/NCBI
2	Zhang JY, Liu B, Wang YN, Zhang WN and Wang FJ: Effect of rosuvastatin on OX40L and PPAR-γ expression in human umbilical vein endothelial cells and atherosclerotic cerebral infarction patients. J Mol Neurosci. 52:261–268. 2014. View Article : Google Scholar : PubMed/NCBI
3	Antunes RF, Kaski JC and Dumitriu IE: The role of costimulatory receptors of the tumour necrosis factor receptor family in atherosclerosis. J Biomed Biotechnol. 2012:4645322012. View Article : Google Scholar : PubMed/NCBI
4	Kamel H and Iadecola C: Brain-immune interactions and ischemic stroke: Clinical implications. Arch Neurol. 69:576–581. 2012. View Article : Google Scholar : PubMed/NCBI
5	Tsai JZ, Peng SJ, Chen YW, Wang KW, Li CH, Wang JY, Chen CJ, Lin HJ, Smith EE, Wu HK, et al: Automated segmentation and quantification of white matter hyperintensities in acute ischemic stroke patients with cerebral infarction. PLoS One. 9:e1040112014. View Article : Google Scholar : PubMed/NCBI
6	Tuttolomondo A, Di Raimondo D, Pecoraro R, Arnao V, Pinto A and Licata G: Inflammation in ischemic stroke subtypes. Curr Pharm Des. 18:4289–4310. 2012. View Article : Google Scholar : PubMed/NCBI
7	Lavrentieva A, Papadopoulou S, Kioumis J, Kaimakamis E and Bitzani M: PCT as a diagnostic and prognostic tool in burn patients. Whether time course has a role in monitoring sepsis treatment. Burns. 38:356–363. 2012. View Article : Google Scholar : PubMed/NCBI
8	Williams LS, Ghose SS and Swindle RW: Depression and other mental health diagnoses increase mortality risk after ischemic stroke. Am J Psychiatry. 161:1090–1095. 2004. View Article : Google Scholar : PubMed/NCBI
9	Zhang F, Li X, Dong Q, Wang Y and Zhang H: Risk of acute cerebral infarction and plasma asymmetrical dimethylarginine and homocysteine levels: A clinical correlation analysis of Chinese population. J Stroke Cerebrovasc Dis. 23:2225–2232. 2014. View Article : Google Scholar : PubMed/NCBI
10	Ahmetgjekaj I, Kabashi-Muçaj S, Lascu LC, Kabashi A, Bondari A, Bondari S, Dedushi-Hoti K, Biçaku A and Shatri J: Magnetic resonance imaging criteria for thrombolysis in hyperacute cerebral infarction. Curr Health Sci J. 40:111–115. 2014.PubMed/NCBI
11	Song Y, Li Q, Long L, Zhang N and Liu Y: Asn563Ser polymorphism of CD31/PECAM-1 is associated with atherosclerotic cerebral infarction in a southern Han population. Neuropsychiatr Dis Treat. 11:15–20. 2014.PubMed/NCBI
12	Maida C, Tuttolomondo A, Di Raimondo D, Daidone M and Pinto A: Management of blood pressure and heart rate in patients with acute stroke. Curr Pharm Des. 23:4583–4597. 2017. View Article : Google Scholar : PubMed/NCBI
13	Khan MM, Motto DG, Lentz SR and Chauhan AK: ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice. J Thromb Haemost. 10:1665–1671. 2012. View Article : Google Scholar : PubMed/NCBI
14	Lambertsen KL, Biber K and Finsen B: Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab. 32:1677–1698. 2012. View Article : Google Scholar : PubMed/NCBI
15	Zu H, Li Q, Huang P and Wang X: Therapeutic value of blood purification and prognostic utilities of early serum procalcitonin, C reactive protein, and brain natriuretic peptide levels in severely burned patients with sepsis. Cell Biochem Biophys. 72:259–263. 2015. View Article : Google Scholar : PubMed/NCBI
16	Dymicka-Piekarska V and Wasiluk A: Procalcitonin (PCT), contemporary indicator of infection and inflammation. Postepy Hig Med Dosw. 69:723–728. 2015.(In Polish). View Article : Google Scholar
17	Gao L, Liu X, Zhang D, Xu F, Chen Q, Hong Y, Feng G, Shi Q, Yang B and Xu L: Early diagnosis of bacterial infection in patients with septicopyemia by laboratory analysis of PCT, CRP and IL-6. Exp Ther Med. 13:3479–3483. 2017. View Article : Google Scholar : PubMed/NCBI
18	Jiao J, Wang M, Zhang J, Shen K, Liao X and Zhou X: Procalcitonin as a diagnostic marker of ventilator-associated pneumonia in cardiac surgery patients. Exp Ther Med. 9:1051–1057. 2015. View Article : Google Scholar : PubMed/NCBI
19	Kumral E, Evyapan D, Gökçay F, Karaman B and Orman M: Association of baseline dyslipidemia with stroke recurrence within five-years after ischemic stroke. Int J Stroke. 9 Suppl A100:119–126. 2014. View Article : Google Scholar : PubMed/NCBI
20	Zhang Z, Ma N, Zheng Y and Zhang L: Association of serum immunoglobulin-G to Porphyromonas gingivalis with acute cerebral infarction in the Chinese population. J Indian Soc Periodontol. 19:628–632. 2015. View Article : Google Scholar : PubMed/NCBI
21	Feng S: Diabetes and hyperglycemia after cerebral infarction in acute cerebral infarction. Diabetes N World. 19:76–78. 2016.(In Chinese).