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Article

Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells

  • Authors:
    • Yi‑Qing Li
    • Jiao‑Ting Chen
    • Song‑Mei Yin
    • Da‑Nian Nie
    • Zhi‑Yuan He
    • Shuang‑Feng Xie
    • Xiu‑Ju Wang
    • Yu‑Dan Wu
    • Jie Xiao
    • Hong‑Yun Liu
    • Jie‑Yu Wang
    • Wen‑Juan Yang
    • Li‑Ping Ma
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 3211-3219
    |
    Published online on: July 30, 2018
       https://doi.org/10.3892/etm.2018.6538
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Abstract

Previous studies have suggested that microsomal prostaglandin E synthase‑1 (mPGES‑1) is highly expressed and closely associated with mitogen‑activated protein kinase (MAPK) signaling pathways in various types of malignant cells. However, their expression patterns and function with respect to T‑cell acute lymphoblastic leukemia (T‑ALL) remain largely unknown. The present study investigated whether mPGES‑1 served a crucial role in T‑ALL and aimed to identify interactions between mPGES‑1 and the MAPK signaling pathway in T‑ALL. The results indicated that mPGES‑1 overexpression in T‑ALL jurkat cells was significantly decreased by RNA silencing. Decreasing mPGES‑1 on a consistent basis may inhibit cell proliferation, induce apoptosis and arrest the cell cycle in T‑ALL jurkat cells. Microarray and western blot analyses revealed that c‑Jun N‑terminal kinase served a role in the mPGES‑1/prostaglandin E2/EP4/MAPK positive feedback loops. In addition, P38 and extracellular signal‑regulated kinase 1/2 exhibited negative feedback effects on mPGES‑1. In conclusion, the results suggested that cross‑talk between mPGES‑1 and the MAPK signaling pathway was very complex. Therefore, the combined regulation of mPGES‑1 and the MAPK signaling pathway may be developed into a new candidate therapy for T‑ALL in the future.
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View References

1 

Roti G and Stegmaier K: New approaches to target T-ALL. Front Oncol. 4:1702014. View Article : Google Scholar : PubMed/NCBI

2 

Zhao WL: Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways. Leukemia. 24:13–21. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Qiu X, Cheng JC, Chang HM and Leung PC: COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion. Endocr Relat Cancer. 21:533–543. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Pan J, Cheng L, Bi X, Zhang X, Liu S, Bai X, Li F and Zhao AZ: Elevation of w-3 polyunsaturated fatty acids attenuates PTEN-deficiency induced endometrial cancer development through regulation of COX-2 and PGE2 production. Sci Rep. 5:149582015. View Article : Google Scholar : PubMed/NCBI

5 

Larsson K, Kock A, Idborg H, Henriksson Arsenian M, Martinsson T, Johnsen JI, Korotkova M, Kogner P and Jakobsson PJ: COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset. Proc Natl Acad Sci U S A. 112:8070–8075. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, et al: The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 342:1946–1952. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Howe LR and Dannenberg AJ: COX-2 inhibitors for the prevention of breast cancer. J Mammary Gland Biol Neoplasia. 8:31–43. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Yiannakopoulou E: Aspirin and NSAIDs for breast cancer chemoprevention. Eur J Cancer Prev. 24:416–421. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Fosbol EL, Kober L, Torp-Pedersen C and Gislason GH: Cardiovascular safety of non-steroidal anti-inflammatory drugs among healthy individuals. Expert Opin Drug Saf. 9:893–903. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Takeuchi K: Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility. World J Gastroenterol. 18:2147–2160. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Larsson K and Jakobsson PJ: Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment. Prostaglandins Other Lipid Mediat. 120:161–165. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Olesch C, Sha W, Angioni C, Sha LK, Açaf E, Patrignani P, Jakobsson PJ, Radeke HH, Grösch S, Geisslinger G, et al: MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget. 6:10284–10296. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Finetti F, Terzuoli E, Giachetti A, Santi R, Villari D, Hanaka H, Radmark O, Ziche M and Donnini S: mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity. Endocr Relat Cancer. 22:665–678. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Li YQ, Yin SM, Xie SF, Wang XJ, Ma LP, Nie DN and Wu YD: Effect of mPGES-1 inhibitor MK886 on cell cycle of leukemia HL-60 cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 20:1072–1076. 2012.(In Chinese). PubMed/NCBI

15 

Li YQ, Yin SM, Nie DN, Xie SF, Ma LP, Wang XJ and Wu YD: Effect of mPGES-1 inhibitor MK886 on apoptosis and drug resistance of HL-60/A cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 20:829–834. 2012.(In Chinese). PubMed/NCBI

16 

Li Y, Yin S, Nie D, Xie S, Ma L, Wang X, Wu Y and Xiao J: MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis. Int J Hematol. 94:472–478. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Munoz L and Ammit AJ: Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology. 58:561–568. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Olajide OA, Bhatia HS, de Oliveira AC, Wright CW and Fiebich BL: Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-κB and p38 MAPK inhibition. Eur J Med Chem. 63:333–339. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Furuya H, Wada M, Shimizu Y, Yamada PM, Hannun YA, Obeid LM and Kawamori T: Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J. 27:656–664. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Olajide OA, Velagapudi R, Okorji UP, Sarker SD and Fiebich BL: Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells. J Ethnopharmacol. 152:377–383. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Okorji UP, Velagapudi R, El-Bakoush A, Fiebich BL and Olajide OA: Antimalarial drug artemether inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms. Mol Neurobiol. 53:6426–6443. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Hu H, Goltsov A, Bown JL, Sims AH, Langdon SP, Harrison DJ and Faratian D: Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer. Cell Signal. 25:26–32. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Bhatia HS, Baron J, Hagl S, Eckert GP and Fiebich BL: Rice bran derivatives alleviate microglia activation: Possible involvement of MAPK pathway. J Neuroinflammation. 13:1482016. View Article : Google Scholar : PubMed/NCBI

24 

Fu P, Liang GJ, Khot SS, Phan R and Bach LA: Cross-talk between MAP kinase pathways is involved in IGF-independent, IGFBP-6-induced Rh30 rhabdomyosarcoma cell migration. J Cell Physiol. 224:636–643. 2010. View Article : Google Scholar : PubMed/NCBI

25 

O'Callaghan G and Houston A: Prostaglandin E2 and the EP receptors in malignancy: Possible therapeutic targets? Br J Pharmacol. 172:5239–5250. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Diaz-Munoz MD, Osma-Garcia IC, Cacheiro-Llaguno C, Fresno M and Iniguez MA: Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages. Cell Signal. 22:1427–1436. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Chabane N, Li X and Fahmi H: HDAC4 contributes to IL-1-induced mPGES-1 expression in human synovial fibroblasts through up-regulation of Egr-1 transcriptional activity. J Cell Biochem. 106:453–463. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Moon Y, Lee M and Yang H: Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells. Biochem Pharmacol. 73:125–135. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Noma T, Takahashi-Yanaga F, Arioka M, Mori Y and Sasaguri T: Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells. Biochem Pharmacol. 116:120–129. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Jakobsson PJ, Thoren S, Morgenstern R and Samuelsson B: Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A. 96:7220–7225. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Tomiyasu H, Watanabe M, Sugita K, Goto-Koshino Y, Fujino Y, Ohno K, Sugano S and Tsujimoto H: Regulations of ABCB1 and ABCG2 expression through MAPK pathways in acute lymphoblastic leukemia cell lines. Anticancer Res. 33:5317–5323. 2013.PubMed/NCBI

32 

Liu Y, Ge J, Li Q, Guo X, Gu L, Ma ZG, Li XH and Zhu YP: Low-dose anisomycin sensitizes glucocorticoid-resistant T-acute lymphoblastic leukemia CEM-C1 cells to dexamethasone-induced apoptosis through activation of glucocorticoid receptor and p38-MAPK/JNK. Leuk Lymphoma. 55:2179–2188. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Naci D and Aoudjit F: Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways. Cell Signal. 26:2008–2015. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S and Sugimoto Y: Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochim Biophys Acta. 1851:414–421. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Xia S, Ma J, Bai X, Zhang H, Cheng S, Zhang M, Zhang L, Du M, Wang Y, Li H, et al: Prostaglandin E2 promotes the cell growth and invasive ability of hepatocellular carcinoma cells by upregulating c-Myc expression via EP4 receptor and the PKA signaling pathway. Oncol Rep. 32:1521–1530. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Du M, Shi F, Zhang H, Xia S, Zhang M, Ma J, Bai X, Zhang L, Wang Y, Cheng S, et al: Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor. Oncol Rep. 34:715–726. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Kim KM, Im AR, Kim SH, Hyun JW and Chae S: Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. Cancer Sci. 107:181–188. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Qian JY, Leung A, Harding P and LaPointe MC: PGE2 stimulates human brain natriuretic peptide expression via EP4 and p42/44 MAPK. Am J Physiol Heart Circ Physiol. 290:H1740–H1746. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Mendez M and LaPointe MC: PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation. Am J Physiol Heart Circ Physiol. 288:H2111–2117. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Ryu WI, Lee H, Kim JH, Bae HC, Ryu HJ and Son SW: IL-33 induces Egr-1-dependent TSLP expression via the MAPK pathways in human keratinocytes. Exp Dermatol. 24:857–863. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Jeong SH, Kim HJ, Ryu HJ, Ryu WI, Park YH, Bae HC, Jang YS and Son SW: ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes. J Dermatol Sci. 72:263–273. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Naraba H, Yokoyama C, Tago N, Murakami M, Kudo I, Fueki M, Oh-Ishi S and Tanabe T: Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1. J Biol Chem. 277:28601–28608. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Khan KM, Kothari P, Du B, Dannenberg AJ and Falcone DJ: Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: Role of TNF-α and the EP4 prostanoid receptor. J Immunol. 188:1970–1980. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Galoian K, Temple HT and Galoyan A: mTORC1 inhibition and ECM-cell adhesion-independent drug resistance via PI3K-AKT and PI3K-RAS-MAPK feedback loops. Tumor Biol. 33:885–890. 2012. View Article : Google Scholar

45 

Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, et al: Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 69:565–572. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li YQ, Chen JT, Yin SM, Nie DN, He ZY, Xie SF, Wang XJ, Wu YD, Xiao J, Liu HY, Liu HY, et al: Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells. Exp Ther Med 16: 3211-3219, 2018.
APA
Li, Y., Chen, J., Yin, S., Nie, D., He, Z., Xie, S. ... Ma, L. (2018). Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells. Experimental and Therapeutic Medicine, 16, 3211-3219. https://doi.org/10.3892/etm.2018.6538
MLA
Li, Y., Chen, J., Yin, S., Nie, D., He, Z., Xie, S., Wang, X., Wu, Y., Xiao, J., Liu, H., Wang, J., Yang, W., Ma, L."Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells". Experimental and Therapeutic Medicine 16.4 (2018): 3211-3219.
Chicago
Li, Y., Chen, J., Yin, S., Nie, D., He, Z., Xie, S., Wang, X., Wu, Y., Xiao, J., Liu, H., Wang, J., Yang, W., Ma, L."Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3211-3219. https://doi.org/10.3892/etm.2018.6538
Copy and paste a formatted citation
x
Spandidos Publications style
Li YQ, Chen JT, Yin SM, Nie DN, He ZY, Xie SF, Wang XJ, Wu YD, Xiao J, Liu HY, Liu HY, et al: Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells. Exp Ther Med 16: 3211-3219, 2018.
APA
Li, Y., Chen, J., Yin, S., Nie, D., He, Z., Xie, S. ... Ma, L. (2018). Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells. Experimental and Therapeutic Medicine, 16, 3211-3219. https://doi.org/10.3892/etm.2018.6538
MLA
Li, Y., Chen, J., Yin, S., Nie, D., He, Z., Xie, S., Wang, X., Wu, Y., Xiao, J., Liu, H., Wang, J., Yang, W., Ma, L."Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells". Experimental and Therapeutic Medicine 16.4 (2018): 3211-3219.
Chicago
Li, Y., Chen, J., Yin, S., Nie, D., He, Z., Xie, S., Wang, X., Wu, Y., Xiao, J., Liu, H., Wang, J., Yang, W., Ma, L."Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3211-3219. https://doi.org/10.3892/etm.2018.6538
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