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Article

Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer

  • Authors:
    • Xiaohua Gu
    • Gang Wang
    • Hui Shen
    • Xiaoyun Fei
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, P.R. China
  • Pages: 3220-3226
    |
    Published online on: August 2, 2018
       https://doi.org/10.3892/etm.2018.6565
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Abstract

Circular RNAs (circRNAs) are a novel type of endogenous RNAs and increasing evidence have uncovered the important role of circRNA in tumor progression; however, the function of circRNAs in non‑small cell lung cancer (NSCLC) remains largely unclear. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. In conclusion, hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Gu X, Wang G, Shen H and Fei X: Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer. Exp Ther Med 16: 3220-3226, 2018.
APA
Gu, X., Wang, G., Shen, H., & Fei, X. (2018). Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer. Experimental and Therapeutic Medicine, 16, 3220-3226. https://doi.org/10.3892/etm.2018.6565
MLA
Gu, X., Wang, G., Shen, H., Fei, X."Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer". Experimental and Therapeutic Medicine 16.4 (2018): 3220-3226.
Chicago
Gu, X., Wang, G., Shen, H., Fei, X."Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3220-3226. https://doi.org/10.3892/etm.2018.6565
Copy and paste a formatted citation
x
Spandidos Publications style
Gu X, Wang G, Shen H and Fei X: Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer. Exp Ther Med 16: 3220-3226, 2018.
APA
Gu, X., Wang, G., Shen, H., & Fei, X. (2018). Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer. Experimental and Therapeutic Medicine, 16, 3220-3226. https://doi.org/10.3892/etm.2018.6565
MLA
Gu, X., Wang, G., Shen, H., Fei, X."Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer". Experimental and Therapeutic Medicine 16.4 (2018): 3220-3226.
Chicago
Gu, X., Wang, G., Shen, H., Fei, X."Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3220-3226. https://doi.org/10.3892/etm.2018.6565
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