Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer

  • Authors:
    • Xiaohua Gu
    • Gang Wang
    • Hui Shen
    • Xiaoyun Fei
  • View Affiliations

  • Published online on: August 2, 2018     https://doi.org/10.3892/etm.2018.6565
  • Pages: 3220-3226
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Abstract

Circular RNAs (circRNAs) are a novel type of endogenous RNAs and increasing evidence have uncovered the important role of circRNA in tumor progression; however, the function of circRNAs in non‑small cell lung cancer (NSCLC) remains largely unclear. In the present study, it was demonstrated that the expression level of hsa_circ_0033155 was significantly downregulated in NSCLC tissue and the expression of hsa_circ_0033155 correlated with lymphatic metastasis. In order to further investigate the possible role of hsa_circ_0033155 in NSCLC progression, circRNA was overexpressed in NSCLC cells and it was observed that the overexpression of hsa_circ_0033155 significantly decreased cell proliferation, colony formation and migration, and elevated the level of phosphatase and tensin homolog deleted on chromosome 10, a tumor suppressor in many types of tumor. In conclusion, hsa_circ_0033155 may serve as a prospective biomarker for detection and a promising therapeutic target for NSCLC.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gu X, Wang G, Shen H and Fei X: Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer. Exp Ther Med 16: 3220-3226, 2018
APA
Gu, X., Wang, G., Shen, H., & Fei, X. (2018). Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer. Experimental and Therapeutic Medicine, 16, 3220-3226. https://doi.org/10.3892/etm.2018.6565
MLA
Gu, X., Wang, G., Shen, H., Fei, X."Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer". Experimental and Therapeutic Medicine 16.4 (2018): 3220-3226.
Chicago
Gu, X., Wang, G., Shen, H., Fei, X."Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3220-3226. https://doi.org/10.3892/etm.2018.6565