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The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer

  • Authors:
    • Zhuo Wu
    • Ye Tian
    • Qian Yu
    • Hongyuan Li
    • Zhiqiang Tian
    • Hongfang Jiang
    • Dali Tian
    • Xueying Yang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3004-3010
    |
    Published online on: August 2, 2018
       https://doi.org/10.3892/etm.2018.6568
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Abstract

Lung cancer is a malignant disease, and has the highest incidence and mortality worldwide. Lung cancer is also a popular subject in the field of cancer research. The molecular mechanisms of lung cancer development, invasion and metastasis need to be determined to prolong survival times and improve the quality of life. Recent studies have demonstrated that ATP-binding cassette sub-family E member 1 (ABCE1) is one of the factors that contributes to the development and metastasis of lung cancer, but the specific mechanism of this phenomenon remains unclear. A polymerase chain reaction microarray was used in the present study to screen for chemokine (C-C motif) ligand 7 (CCL7) expression in cell lines that highly expressed ABCE1, and the results showed that CCL7 was highly expressed in H1299 cells (P<0.01). The expression of CCL7 and ABCE1 in lung cancer tissues obtained from 30 patients with non‑small cell lung cancer (NSCLC) was higher than that in adjacent normal lung tissues (P<0.01), and a positive correlation between the expression levels of the two genes in NSCLC was observed. These findings indicate that ABCE1 is involved in the development and progression of lung cancer through the CCL7 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Wu Z, Tian Y, Yu Q, Li H, Tian Z, Jiang H, Tian D and Yang X: The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer. Exp Ther Med 16: 3004-3010, 2018.
APA
Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H. ... Yang, X. (2018). The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer. Experimental and Therapeutic Medicine, 16, 3004-3010. https://doi.org/10.3892/etm.2018.6568
MLA
Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H., Tian, D., Yang, X."The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer". Experimental and Therapeutic Medicine 16.4 (2018): 3004-3010.
Chicago
Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H., Tian, D., Yang, X."The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3004-3010. https://doi.org/10.3892/etm.2018.6568
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Z, Tian Y, Yu Q, Li H, Tian Z, Jiang H, Tian D and Yang X: The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer. Exp Ther Med 16: 3004-3010, 2018.
APA
Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H. ... Yang, X. (2018). The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer. Experimental and Therapeutic Medicine, 16, 3004-3010. https://doi.org/10.3892/etm.2018.6568
MLA
Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H., Tian, D., Yang, X."The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer". Experimental and Therapeutic Medicine 16.4 (2018): 3004-3010.
Chicago
Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H., Tian, D., Yang, X."The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3004-3010. https://doi.org/10.3892/etm.2018.6568
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