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Case Report Open Access

Eosinophilic cystitis in children: A case report

  • Authors:
    • Jun He
    • Feng Ning
    • Lei Tu
    • Jianjun Hu
    • Weijian Chen
    • Yaowang Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Hunan Children's Hospital, Changsha, Hunan 410007, P.R. China, Department of Radiology, Hunan Children's Hospital, Changsha, Hunan 410007, P.R. China, Department of Pathology, Hunan Children's Hospital, Changsha, Hunan 410007, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2978-2984
    |
    Published online on: August 7, 2018
       https://doi.org/10.3892/etm.2018.6578
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Abstract

The aim of the present case report was to investigate the clinical features, pathological examination and treatment of eosinophilic cystitis (EC) in children. Two cases of EC were reported and reviewed from January 2016 to March 2017. Case 1 (male; 6 years old) had intermittent hematuria, frequent urination, urgent urination, difficulty in urination and abdominal pain. Case 2 (male; 7 years old) had frequent urination, urgent urination, urinary pain, dysuria and suprapubic pain with no hematuria. One patient had a history of allergies and both patients underwent a cystoscope biopsy. Blood eosinophils were clearly increased and a bone marrow biopsy examination revealed that marrow eosinophils were also increased in both cases. The urine culture results were negative. Ultrasonography and computed tomography revealed uneven thickening of the bladder wall and diffusive mucosal lesions. Cystoscopy revealed that the bladder volume became smaller and the mucosa at the bladder floor and neck was red. Lesions were biopsied through the urethra and the following characteristics were observed: Congestion and edema of the bladder mucosa, infiltration of the blood vessels and eosinophils in the muscular layer, accompanied by focal muscle necrosis. Patient 1 was administered anti‑inflammatory and cetirizine hydrochloride treatments, followed by 6 weeks of prednisone dose‑reduction therapy. Patient 2 was administered antibiotics and cetirizine hydrochloride. Following 6‑month follow‑ups, abnormal voiding symptoms had disappeared in each case. Ultrasonography and computed tomography revealed no bladder wall thickening or space‑occupying lesions. EC in children is rare and easily misdiagnosed as nonspecific bladder inflammation or bladder occupying lesions. Cystoscopy and biopsy are necessary to diagnose EC and conservative treatments with anti‑inflammatory, anti‑allergic and cortical hormone nonspecific treatments are suggested.
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Copy and paste a formatted citation
Spandidos Publications style
He J, Ning F, Tu L, Hu J, Chen W and Zhao Y: Eosinophilic cystitis in children: A case report. Exp Ther Med 16: 2978-2984, 2018.
APA
He, J., Ning, F., Tu, L., Hu, J., Chen, W., & Zhao, Y. (2018). Eosinophilic cystitis in children: A case report. Experimental and Therapeutic Medicine, 16, 2978-2984. https://doi.org/10.3892/etm.2018.6578
MLA
He, J., Ning, F., Tu, L., Hu, J., Chen, W., Zhao, Y."Eosinophilic cystitis in children: A case report". Experimental and Therapeutic Medicine 16.4 (2018): 2978-2984.
Chicago
He, J., Ning, F., Tu, L., Hu, J., Chen, W., Zhao, Y."Eosinophilic cystitis in children: A case report". Experimental and Therapeutic Medicine 16, no. 4 (2018): 2978-2984. https://doi.org/10.3892/etm.2018.6578
Copy and paste a formatted citation
x
Spandidos Publications style
He J, Ning F, Tu L, Hu J, Chen W and Zhao Y: Eosinophilic cystitis in children: A case report. Exp Ther Med 16: 2978-2984, 2018.
APA
He, J., Ning, F., Tu, L., Hu, J., Chen, W., & Zhao, Y. (2018). Eosinophilic cystitis in children: A case report. Experimental and Therapeutic Medicine, 16, 2978-2984. https://doi.org/10.3892/etm.2018.6578
MLA
He, J., Ning, F., Tu, L., Hu, J., Chen, W., Zhao, Y."Eosinophilic cystitis in children: A case report". Experimental and Therapeutic Medicine 16.4 (2018): 2978-2984.
Chicago
He, J., Ning, F., Tu, L., Hu, J., Chen, W., Zhao, Y."Eosinophilic cystitis in children: A case report". Experimental and Therapeutic Medicine 16, no. 4 (2018): 2978-2984. https://doi.org/10.3892/etm.2018.6578
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