Open Access

Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin

  • Authors:
    • Jie-Yang Yu
    • Jia-Hua Peng
    • Li Hui
    • Hui-Quan Huang
    • Ming-Hua Tan
    • Guo Jian
  • View Affiliations

  • Published online on: August 9, 2018     https://doi.org/10.3892/etm.2018.6591
  • Pages: 3534-3538
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Abstract

The present study was designed to investigate the association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin (HNL). A total of 112 patients confirmed with traumatic hemorrhage were enrolled as study subjects and were randomly divided into the control group (n=56) and observation group (n=56). The control group was treated with rapid fluid resuscitation, and the observation group was treated with controlled fluid resuscitation. The success rate of resuscitation, incidence rate of complications, and HNL levels were compared both before and after resuscitation at multiple time intervals. The success rate of resuscitation showed a significant improvement while the incidence rate of complications were decreased. The HNL levels in both groups revealed increase after resuscitation at 3-10 h, thereby, they showed decline following peak point. However, the peak reduction in the observation group appeared earlier, while the HNL levels at 24 and 72 h were significantly lower than those in the control group. The study concluded that the effect of controlled fluid resuscitation on massive hemorrhage was superior to that of rapid fluid resuscitation. Moreover, controlled fluid resuscitation was also able to decrease the level of HNL as well as inflammatory response.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu J, Peng J, Hui L, Huang H, Tan M and Jian G: Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin. Exp Ther Med 16: 3534-3538, 2018
APA
Yu, J., Peng, J., Hui, L., Huang, H., Tan, M., & Jian, G. (2018). Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin. Experimental and Therapeutic Medicine, 16, 3534-3538. https://doi.org/10.3892/etm.2018.6591
MLA
Yu, J., Peng, J., Hui, L., Huang, H., Tan, M., Jian, G."Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin". Experimental and Therapeutic Medicine 16.4 (2018): 3534-3538.
Chicago
Yu, J., Peng, J., Hui, L., Huang, H., Tan, M., Jian, G."Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3534-3538. https://doi.org/10.3892/etm.2018.6591