Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4)

  • Authors:
    • Xinyi Li
    • Jin Wang
    • Huisheng Wu
    • Peipei Guo
    • Chengyao Wang
    • Yanlin Wang
    • Zongze Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 3632-3638
    |
    Published online on: August 13, 2018
       https://doi.org/10.3892/etm.2018.6599
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute lung injury (ALI) is a common complication of sepsis to which patients often succumb due to poor effective pharmacological interventions. Recent studies have focused on the potential application of circulating microRNAs (miRs or miRNAs) as novel prognostic and therapeutic biomarkers. The present study focuses mainly on miR‑140, the role of which is poorly understood in the progression of ALI. The results of the present study revealed that toll‑like receptor 4 (TLR4) expression was upregulated the lungs of rats with ALI. Meanwhile, serum levels of tumor necrosis factor‑α, interleukin (IL)‑6 and IL‑1β were significantly increased in rats with ALI compared with normal control rats. These data indicated the successful establishment of LPS‑induced ALI. Furthermore, miR‑140 was decreased in the peripheral blood of patients with ALI compared with control subjects. Receiver operator characteristic analysis indicated that miR‑140 could be used to screen ALI patients and distinguish them from healthy controls. MiR‑140 was demonstrated to be downregulated in the plasma and lungs of rats with ALI compared with the normal control group. A dual luciferase reporter assay indicated that TLR4 was a target gene of miR‑140. To investigate whether miR‑140 exerted its role via TLR4, a specific TLR4‑targeting small interfering RNA was selected. It was revealed that TLR4 silencing was able to suppress the phosphorylation of NF‑κB even in cells transfected with miR‑140 inhibitor. In summary, reduced miR‑140 expression and increased TLR4 signaling activation may serve a key role in the progression of ALI.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Deng J, Wang DX, Liang AL, Tang J and Xiang DK: Effects of baicalin on alveolar fluid clearance and α-ENaC expression in rats with LPS-induced acute lung injury. Can J Physiol Pharmacol. 95:122–128. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Fragoso IT, Ribeiro EL, Gomes FO, Donato MA, Silva AK, Oliveira AC, Araújo SM, Barbosa KP, Santos LA and Peixoto CA: Diethylcarbamazine attenuates LPS-induced acute lung injury in mice by apoptosis of inflammatory cells. Pharmacol Rep. 69:81–89. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Hsia TC and Yin MC: Post-intake of S-ethyl cysteine and S-methyl cysteine improved LPS-induced acute lung injury in mice. Nutrients. 8:pii: E5072016. View Article : Google Scholar

4 

Hu Y, Lou J, Mao YY, Lai TW, Liu LY, Zhu C, Zhang C, Liu J, Li YY, Zhang F, et al: Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy. 12:2286–2299. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Huang WC, Lai CL, Liang YT, Hung HC, Liu HC and Liou CJ: Phloretin attenuates LPS-induced acute lung injury in mice via modulation of the NF-κB and MAPK pathways. Int Immunopharmacol. 40:98–105. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Jang YJ, Back MJ, Fu Z, Lee JH, Won JH, Ha HC, Lee HK, Jang JM, Choi JM and Kim DK: Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury. Arch Pharm Res. 39:1716–1725. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Kim J, Jeong SW, Quan H, Jeong CW, Choi JI and Bae HB: Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK. J Anesth. 30:100–108. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Jiang L, Zhang L, Kang K, Fei D, Gong R, Cao Y, Pan S and Zhao M and Zhao M: Resveratrol ameliorates LPS-induced acute lung injury via NLRP3 inflammasome modulation. Biomed Pharmacother. 84:130–138. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Li W, Qiu X, Jiang H, Han Y, Wei D and Liu J: Downregulation of miR-181a protects mice from LPS-induced acute lung injury by targeting Bcl-2. Biomed Pharmacother. 84:1375–1382. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zhou Z and You Z: Mesenchymal stem cells alleviate LPS-induced acute lung injury in mice by MiR-142a-5p-controlled pulmonary endothelial cell autophagy. Cell Physiol Biochem. 38:258–266. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Tao Z, Yuan Y and Liao Q: Alleviation of lipopolysaccharides-induced acute lung injury by MiR-454. Cell Physiol Biochem. 38:65–74. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Xiao J, Tang J, Chen Q, Tang D, Liu M, Luo M, Wang Y, Wang J, Zhao Z, Tang C, et al: miR-429 regulates alveolar macrophage inflammatory cytokine production and is involved in LPS-induced acute lung injury. Biochem J. 471:281–291. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Bao H, Gao F, Xie G and Liu Z: Angiotensin-converting enzyme 2 inhibits apoptosis of pulmonary endothelial cells during acute lung injury through suppressing MiR-4262. Cell Physiol Biochem. 37:759–767. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Syed M, Das P, Pawar A, Aghai ZH, Kaskinen A, Zhuang ZW, Ambalavanan N, Pryhuber G, Andersson S and Bhandari V: Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs. Nat Commun. 8:11732017. View Article : Google Scholar : PubMed/NCBI

15 

Liu Q, Du J, Yu X, Xu J, Huang F, Li X, Zhang C, Li X, Chang J, Shang D, et al: miRNA-200c-3p is crucial in acute respiratory distress syndrome. Cell Discov. 3:170212017. View Article : Google Scholar : PubMed/NCBI

16 

Wu X, Xia M, Chen D, Wu F, Lv Z, Zhan Q, Jiao Y, Wang W, Chen G and An F: Profiling of downregulated blood-circulating miR-150-5p as a novel tumor marker for cholangiocarcinoma. Tumour Biol. 37:15019–15029. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Huang Y, Tang S, Ji-Yan C, Huang C, Li J, Cai AP and Feng YQ: Circulating miR-92a expression level in patients with essential hypertension: A potential marker of atherosclerosis. J Hum Hypertens. 31:200–205. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Coskunpinar E, Cakmak HA, Kalkan AK, Tiryakioglu NO, Erturk M and Ongen Z: Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction. Gene. 591:90–96. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yuan R, Wang G, Xu Z, Zhao H, Chen H, Han Y, Wang B, Zhou J, Hu H, Guo Z, et al: Up-regulated circulating miR-106a by DNA methylation promised a potential diagnostic and prognostic marker for gastric cancer. Anticancer Agents Med Chem. 16:1093–1100. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Han Y, Li Y and Jiang Y: The prognostic value of plasma MicroRNA-155 and MicroRNA-146a level in severe sepsis and sepsis-induced acute lung injury patients. Clin Lab. 62:2355–2360. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Cui Y, Yi L, Zhao JZ and Jiang YG: Long noncoding RNA HOXA11-AS functions as miRNA sponge to promote the glioma tumorigenesis through targeting miR-140-5p. DNA Cell Biol. 36:822–828. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Fang Z, Yin S, Sun R, Zhang S, Fu M, Wu Y, Zhang T, Khaliq J and Li Y: miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1. Mol Cancer. 16:1392017. View Article : Google Scholar : PubMed/NCBI

23 

Sun Z, Zhou D, Xie X, Wang S, Wang Z, Zhao W, Xu H and Zheng L: Cross-talk between macrophages and atrial myocytes in atrial fibrillation. Basic Res Cardiol. 111:632016. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Carvalho JL, Britto A, de Oliveira AP, Castro-Faria-Neto H, Albertini R, Anatriello E and Aimbire F: Beneficial effect of low-level laser therapy in acute lung injury after i-I/R is dependent on the secretion of IL-10 and independent of the TLR/MyD88 signaling. Lasers Med Sci. 32:305–315. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Xu C, Chen G, Yang W, Xu Y, Xu Y, Huang X, Liu J, Feng Y, Xu Y and Liu B: Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor (TLR) 4-dependent signaling pathways. Int immunopharmacol. 28:1050–1058. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Chen C, Wang YL, Wang CY and Zhang ZZ: Effect of TLR-4 and HO-1 on acute lung injury induced by hemorrhagic shock in mice. Chin J Traumatol. 11:78–83. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Cabrera-Perez J, Babcock JC, Dileepan T, Murphy KA, Kucaba TA, Badovinac VP and Griffith TS: Gut microbial membership modulates CD4 T cell reconstitution and function after sepsis. J Immunol. 197:1692–1698. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Barsness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, Reznikov L and McIntyre RC: Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol. 287:R592–R599. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Sodhi CP, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR and Hackam DJ: Intestinal epithelial TLR-4 activation is required for the development of acute lung injury after trauma/hemorrhagic shock via the release of HMGB1 from the gut. J Immunol. 194:4931–4939. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Tianzhu Z and Shumin W: Esculin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of TLR/NF-κB pathways. Inflammation. 38:1529–1536. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Wang CC, Yuan JR, Wang CF, Yang N, Chen J, Liu D, Song J, Feng L, Tan XB and Jia XB: Anti-inflammatory effects of phyllanthus emblica L on benzopyrene-induced precancerous lung lesion by regulating the IL-1β/miR-101/Lin28B signaling pathway. Integr Cancer Ther. 16:505–515. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, Mitchell PS, Bennett CF, Pogosova-Agadjanyan EL, Stirewalt DL, et al: Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA. 108:5003–5008. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Kroh EM, Parkin RK, Mitchell PS and Tewari M: Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods. 50:298–301. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Jiang K, Guo S, Zhang T, Yang Y, Zhao G, Shaukat A, Wu H and Deng G: Downregulation of TLR4 by miR-181a provides negative feedback regulation to lipopolysaccharide-induced inflammation. Front Pharmacol. 9:1422018. View Article : Google Scholar : PubMed/NCBI

36 

Brogaard L, Larsen LE, Heegaard PMH, Anthon C, Gorodkin J, Dürrwald R and Skovgaard K: IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs. PLoS One. 13:e01947652018. View Article : Google Scholar : PubMed/NCBI

37 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Cheng HH, Mitchell PS, Kroh EM, Dowell AE, Chéry L, Siddiqui J, Nelson PS, Vessella RL, Knudsen BS, Chinnaiyan AM, et al: Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancer-associated hypoxia. PLoS One. 8:e692392013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Wang J, Wu H, Guo P, Wang C, Wang Y and Zhang Z: Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4). Exp Ther Med 16: 3632-3638, 2018.
APA
Li, X., Wang, J., Wu, H., Guo, P., Wang, C., Wang, Y., & Zhang, Z. (2018). Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4). Experimental and Therapeutic Medicine, 16, 3632-3638. https://doi.org/10.3892/etm.2018.6599
MLA
Li, X., Wang, J., Wu, H., Guo, P., Wang, C., Wang, Y., Zhang, Z."Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4)". Experimental and Therapeutic Medicine 16.4 (2018): 3632-3638.
Chicago
Li, X., Wang, J., Wu, H., Guo, P., Wang, C., Wang, Y., Zhang, Z."Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4)". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3632-3638. https://doi.org/10.3892/etm.2018.6599
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wang J, Wu H, Guo P, Wang C, Wang Y and Zhang Z: Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4). Exp Ther Med 16: 3632-3638, 2018.
APA
Li, X., Wang, J., Wu, H., Guo, P., Wang, C., Wang, Y., & Zhang, Z. (2018). Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4). Experimental and Therapeutic Medicine, 16, 3632-3638. https://doi.org/10.3892/etm.2018.6599
MLA
Li, X., Wang, J., Wu, H., Guo, P., Wang, C., Wang, Y., Zhang, Z."Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4)". Experimental and Therapeutic Medicine 16.4 (2018): 3632-3638.
Chicago
Li, X., Wang, J., Wu, H., Guo, P., Wang, C., Wang, Y., Zhang, Z."Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4)". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3632-3638. https://doi.org/10.3892/etm.2018.6599
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team