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USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway

  • Authors:
    • Xiandong Song
    • Min Zhu
    • Hao Li
    • Bo Liu
    • Zhaowei Yan
    • Weican Wang
    • Hongyi Li
    • Jiping Sun
    • Shixing Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Hongqi Hospital Affiliated with Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China, Department of Radiology, Hongqi Hospital Affiliated with Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3518-3524
    |
    Published online on: August 14, 2018
       https://doi.org/10.3892/etm.2018.6608
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Abstract

The current study mainly aims to evaluate the expression pattern and underlying mechanism of upstream stimulating factor 1 (USF1) in the muscle tissues of knee osteoarthritis (KOA) patients. In accordance with previous findings, our data showed that muscle strength was significantly decreased in KOA patients compared with controls. Furthermore, several inflammatory factors, including tumor necrosis factor α (TNFα), IL‑8, IL‑6 and MCP‑1, were associated with reduced muscle strength in KOA patients. Not surprisingly, NF‑κB signaling was significantly activated in the muscle tissues of KOA patients compared with control individuals. Furthermore, we showed that USF1 was increased in the muscles of KOA patients compared with controls. More importantly, overexpression of USF1 in primary human skeletal muscle cells significantly increased the activation of NF‑κB signaling as well as the levels of pro‑inflammatory factors. In summary, we showed novel data that the upregulation of USF1 promoted NF‑κB activation‑induced inflammatory responses in muscle tissues of KOA patients.
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Copy and paste a formatted citation
Spandidos Publications style
Song X, Zhu M, Li H, Liu B, Yan Z, Wang W, Li H, Sun J and Li S: USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway. Exp Ther Med 16: 3518-3524, 2018.
APA
Song, X., Zhu, M., Li, H., Liu, B., Yan, Z., Wang, W. ... Li, S. (2018). USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 16, 3518-3524. https://doi.org/10.3892/etm.2018.6608
MLA
Song, X., Zhu, M., Li, H., Liu, B., Yan, Z., Wang, W., Li, H., Sun, J., Li, S."USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 16.4 (2018): 3518-3524.
Chicago
Song, X., Zhu, M., Li, H., Liu, B., Yan, Z., Wang, W., Li, H., Sun, J., Li, S."USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3518-3524. https://doi.org/10.3892/etm.2018.6608
Copy and paste a formatted citation
x
Spandidos Publications style
Song X, Zhu M, Li H, Liu B, Yan Z, Wang W, Li H, Sun J and Li S: USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway. Exp Ther Med 16: 3518-3524, 2018.
APA
Song, X., Zhu, M., Li, H., Liu, B., Yan, Z., Wang, W. ... Li, S. (2018). USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 16, 3518-3524. https://doi.org/10.3892/etm.2018.6608
MLA
Song, X., Zhu, M., Li, H., Liu, B., Yan, Z., Wang, W., Li, H., Sun, J., Li, S."USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 16.4 (2018): 3518-3524.
Chicago
Song, X., Zhu, M., Li, H., Liu, B., Yan, Z., Wang, W., Li, H., Sun, J., Li, S."USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3518-3524. https://doi.org/10.3892/etm.2018.6608
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