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Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway

  • Authors:
    • Yu Xi
    • Jianhua Niu
    • Dongmei Li
    • Jiagen He
    • Le Qin
    • Xinyu Peng
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of General Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832008, P.R. China
    Copyright: © Xi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3317-3324
    |
    Published online on: August 20, 2018
       https://doi.org/10.3892/etm.2018.6618
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Abstract

Mixed lineage kinase‑4 (MLK‑4) is an important member of the mixed‑lineage family of kinases that regulates the extracellular signal‑regulated kinases and c‑Jun N‑terminal kinase (JNK) signaling pathways. The functions and mechanisms of MLK‑4 in cancer initiation and progression have not been well understood. The present study investigated the expression, function and regulatory mechanism of MLK‑4 in gastric carcinoma cells. Biochemical data indicated that normal MLK‑4 was downregulated, which exerted dominant negative effects on gastric carcinoma cell viability, migration and invasion. The experimental data demonstrated that MLK‑4 supplement abrogated activity of these mutants and induced inhibitory effects on gastric carcinoma cell viabilty, migration and invasion in vitro and in vivo. In addition, to determine the regulatory mechanism of MLK‑4, its signaling pathway was assessed in gastric carcinoma cancer cells by regulating MLK‑4. The present observations indicated that restoring MLK‑4 activity by supplemental MLK‑4 reduced gastric carcinoma cell colony formation in vitro and suppressed tumor viability, migration and invasion in vivo. The results of the present study indicated that MLK‑4 may be a potential protein for targeting gastric carcinoma by suppressing kinases, which may lead to reduction of JNK signaling and enhance therapeutic efficacy in gastric carcinoma.
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1 

Areia M, Carvalho R, Cadime AT, Rocha Goncalves F and Dinis-Ribeiro M: Screening for gastric cancer and surveillance of premalignant lesions: A systematic review of cost-effectiveness studies. Helicobacter. 18:325–337. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Hossain MM and Chen Z: Comments on ‘Application of an adaptive design to a randomized phase II selection trial in gastric cancer: A report of the study design’ by Satoshi Morita and Junichi Sakamoto. Pharm Stat. 11:267–268. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Pimenta-Melo AR, Monteiro-Soares M, Libânio D and Dinis-Ribeiro M: Missing rate for gastric cancer during upper gastrointestinal endoscopy: A systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 28:1041–1019. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Veisani Y and Delpisheh A: Survival rate of gastric cancer in Iran; a systematic review and meta-analysis. Gastroenterol Hepatol Bed Bench. 9:78–86. 2016.PubMed/NCBI

5 

Nakajima T, Inokuchi K, Hattori T, Inoue K, Taguchi T, Kondou T, Abe O, Kikuchi K, Tanabe T and Ogawa N: Multi-institutional cooperative study of adjuvant immunochemotherapy in gastric cancer-five-year survival rate. Gan To Kagaku Ryoho. 16:799–806. 1989.(In Japanese). PubMed/NCBI

6 

Jung SA, Park YM, Hong SW, Moon JH, Shin JS, Lee HR, Ha SH, Lee DH, Kim JH, Kim SM, et al: Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells. J Biol Chem. 290:9974–9985. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Izawa M, Mori T, Satoh T, Teramachi K and Sairenji T: Identification of an alternative form of caspase-9 in human gastric cancer cell lines: A role of a caspase-9 variant in apoptosis resistance. Apoptosis. 4:321–325. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Moody SE, Schinzel AC, Singh S, Izzo F, Strickland MR, Luo L, Thomas SR, Boehm JS, Kim SY, Wang ZC and Hahn WC: PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene. 34:2061–2071. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Shiota M, Yokomizo A and Naito S: Pro-survival and anti-apoptotic properties of androgen receptor signaling by oxidative stress promote treatment resistance in prostate cancer. Endocr Relat Cancer. 19:R243–R253. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K and Nakajima Y: PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis. Cancer Res. 72:4829–4839. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Coccolini F, Catena F, Glehen O, Yonemura Y, Sugarbaker PH, Piso P, Ceresoli M, Montori G and Ansaloni L: Effect of intraperitoneal chemotherapy and peritoneal lavage in positive peritoneal cytology in gastric cancer. Systematic review and meta-analysis. Eur J Surg Oncol. 42:1261–1267. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Li K and Li J: Current molecular targeted therapy in advanced gastric cancer: A comprehensive review of therapeutic mechanism, clinical trials, and practical application. Gastroenterol Res Pract. 2016:41056152016. View Article : Google Scholar : PubMed/NCBI

13 

Marusiak AA, Edwards ZC, Hugo W, Trotter EW, Girotti MR, Stephenson NL, Kong X, Gartside MG, Fawdar S, Hudson A, et al: Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors. Nat Commun. 5:39012014. View Article : Google Scholar : PubMed/NCBI

14 

Handley ME, Rasaiyaah J, Barnett J, Thakker M, Pollara G, Katz DR and Chain BM: Expression and function of mixed lineage kinases in dendritic cells. Int Immunol. 19:923–933. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Jaeschke A and Davis RJ: Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell. 27:498–508. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Martini M, Russo M, Lamba S, Vitiello E, Crowley EH, Sassi F, Romanelli D, Frattini M, Marchetti A and Bardelli A: Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis. Cancer Res. 73:1912–1921. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Seit-Nebi A, Cheng W, Xu H and Han J: MLK4 has negative effect on TLR4 signaling. Cell Mol Immunol. 9:27–33. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Lee JY, Yoo NJ and Lee SH: Kinase domain mutation of MLK4 gene is uncommon in gastric and hepatocellular carcinomas. Dig Liver Dis. 38:2832006. View Article : Google Scholar : PubMed/NCBI

19 

Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, et al: Serine/Threonine kinase MLK4 determines mesenchymal identity in glioma stem cells in an NF-κB-dependent manner. Cancer Cell. 29:201–213. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Marusiak AA, Stephenson NL, Baik H, Trotter EW, Li Y, Blyth K, Mason S, Chapman P, Puto LA, Read JA, et al: Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Res. 76:724–735. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Kohli M, Rago C, Lengauer C, Kinzler KW and Vogelstein B: Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res. 32:e32004. View Article : Google Scholar : PubMed/NCBI

22 

Xiao S, Wang J and Xiao N: MicroRNAs as noninvasive biomarkers in bladder cancer detection: A diagnostic meta-analysis based on qRT-PCR data. Int J Biol Markers. 31:e276–e285. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Wai-Hoe L, Wing-Seng L, Ismail Z and Lay-Harn G: SDS-PAGE-based quantitative assay for screening of kidney stone disease. Biol Proced Online. 11:145–160. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Zhuang T, Djemil T, Qi P, Magnelli A, Stephans K, Videtic G and Xia P: Dose calculation differences between Monte Carlo and pencil beam depend on the tumor locations and volumes for lung stereotactic body radiation therapy. J Appl Clin Med Phys. 14:40112013. View Article : Google Scholar : PubMed/NCBI

26 

Ruan J, Mei L, Zhu Q, Shi G and Wang H: Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer. Int J Clin Exp Pathol. 8:15035–15038. 2015.PubMed/NCBI

27 

Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS and Wang X: Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell. 54:133–146. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Gallo KA and Johnson GL: Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol. 3:663–672. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Lotharius J, Falsig J, van Beek J, Payne S, Dringen R, Brundin P and Leist M: Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway. J Neurosci. 25:6329–6342. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Chinchar E, Makey KL, Gibson J, Chen F, Cole SA, Megason GC, Vijayakumar S, Miele L and Gu JW: Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells. Vasc Cell. 6:122014. View Article : Google Scholar : PubMed/NCBI

31 

Guidicelli G, Chaigne-Delalande B, Dilhuydy MS, Pinson B, Mahfouf W, Pasquet JM, Mahon FX, Pourquier P, Moreau JF and Legembre P: The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells. PLoS One. 4:e54932009. View Article : Google Scholar : PubMed/NCBI

32 

Vacratsis PO and Gallo KA: Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylation of Thr258 of murine MITOGEN-ACTIVATED protein kinase kinase 4. J Biol Chem. 275:27893–27900. 2000.PubMed/NCBI

33 

Wang L, Gallo KA and Conrad SE: Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Oncotarget. 4:1158–1171. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Müller GJ, Geist MA, Veng LM, Willesen MG, Johansen FF, Leist M and Vaudano E: A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption. J Neurochem. 96:1242–1252. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Mota M, Reeder M, Chernoff J and Bazenet CE: Evidence for a role of mixed lineage kinases in neuronal apoptosis. J Neurosci. 21:4949–4957. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Fang W, Jia ZS and Tong ZS: Research progress in mixed lineage kinase domain-like. Sheng Li Ke Xue Jin Zhan. 46:265–268. 2015.PubMed/NCBI

37 

Garlena RA, Gonda RL, Green AB, Pileggi RM and Stronach B: Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis. J Cell Sci. 123:3177–3188. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xi Y, Niu J, Li D, He J, Qin L and Peng X: Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway. Exp Ther Med 16: 3317-3324, 2018.
APA
Xi, Y., Niu, J., Li, D., He, J., Qin, L., & Peng, X. (2018). Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway. Experimental and Therapeutic Medicine, 16, 3317-3324. https://doi.org/10.3892/etm.2018.6618
MLA
Xi, Y., Niu, J., Li, D., He, J., Qin, L., Peng, X."Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway". Experimental and Therapeutic Medicine 16.4 (2018): 3317-3324.
Chicago
Xi, Y., Niu, J., Li, D., He, J., Qin, L., Peng, X."Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3317-3324. https://doi.org/10.3892/etm.2018.6618
Copy and paste a formatted citation
x
Spandidos Publications style
Xi Y, Niu J, Li D, He J, Qin L and Peng X: Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway. Exp Ther Med 16: 3317-3324, 2018.
APA
Xi, Y., Niu, J., Li, D., He, J., Qin, L., & Peng, X. (2018). Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway. Experimental and Therapeutic Medicine, 16, 3317-3324. https://doi.org/10.3892/etm.2018.6618
MLA
Xi, Y., Niu, J., Li, D., He, J., Qin, L., Peng, X."Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway". Experimental and Therapeutic Medicine 16.4 (2018): 3317-3324.
Chicago
Xi, Y., Niu, J., Li, D., He, J., Qin, L., Peng, X."Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3317-3324. https://doi.org/10.3892/etm.2018.6618
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