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Article

Protective role of propofol in endometriosis and its mechanism

  • Authors:
    • Shuo Feng
    • Yingui Sun
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261053, P.R. China, Department of Anesthesiology, Weifang Medical University, Weifang, Shandong 261053, P.R. China
  • Pages: 3646-3650
    |
    Published online on: August 22, 2018
       https://doi.org/10.3892/etm.2018.6648
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Abstract

Endometriosis (EM) is a common benign gynecological disorder. The present study aimed to investigate the potential role of propofol, a commonly used intravenous anesthetic agent, in the pathogenesis of EM. The EM cell line CRL‑7566 was used in the present study. CRL‑7566 cells were first treated with various concentrations of propofol (0, 1, 5 or 10 µg/ml) for specific duration, and the cell viability and apoptotic rate were determined by performing an MTT and a flow cytometric cell apoptosis assay, respectively. The protein and mRNA levels of cell proliferation‑ and apoptosis‑associated genes were detected by western blot and reverse‑transcription quantitative polymerase chain reaction, respectively. The results demonstrated that propofol inhibited CRL‑7566 cell proliferation in a dose‑ and time‑dependent manner. CRL‑7566 cell apoptosis was dose‑dependently induced by propofol treatment. In addition, propofol treatment significantly increased the levels of forkhead box (FOX)O1, FOXO3, Bim, pro‑caspase‑3, active caspase‑3, p53 and p21. In conclusion, the present study suggested that propofol inhibited the proliferation and induced apoptosis of EM cells via inducing the expression/activation of multiple associated genes/proteins, indicating a protective role of propofol in EM.
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Copy and paste a formatted citation
Spandidos Publications style
Feng S and Sun Y: Protective role of propofol in endometriosis and its mechanism. Exp Ther Med 16: 3646-3650, 2018.
APA
Feng, S., & Sun, Y. (2018). Protective role of propofol in endometriosis and its mechanism. Experimental and Therapeutic Medicine, 16, 3646-3650. https://doi.org/10.3892/etm.2018.6648
MLA
Feng, S., Sun, Y."Protective role of propofol in endometriosis and its mechanism". Experimental and Therapeutic Medicine 16.4 (2018): 3646-3650.
Chicago
Feng, S., Sun, Y."Protective role of propofol in endometriosis and its mechanism". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3646-3650. https://doi.org/10.3892/etm.2018.6648
Copy and paste a formatted citation
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Spandidos Publications style
Feng S and Sun Y: Protective role of propofol in endometriosis and its mechanism. Exp Ther Med 16: 3646-3650, 2018.
APA
Feng, S., & Sun, Y. (2018). Protective role of propofol in endometriosis and its mechanism. Experimental and Therapeutic Medicine, 16, 3646-3650. https://doi.org/10.3892/etm.2018.6648
MLA
Feng, S., Sun, Y."Protective role of propofol in endometriosis and its mechanism". Experimental and Therapeutic Medicine 16.4 (2018): 3646-3650.
Chicago
Feng, S., Sun, Y."Protective role of propofol in endometriosis and its mechanism". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3646-3650. https://doi.org/10.3892/etm.2018.6648
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