Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index

  • Authors:
    • Zheng Liu
    • Fang Shi
    • Jun‑Xia Liu
    • Chang‑Lan Gao
    • Meng‑Miao Pei
    • Jing Li
    • Pei‑Xiu Li
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Tract Medicine, The Petroleum Clinical Medical College of Hebei Medical University, Langfang, Hebei 065000, P.R. China, Department of Radiology, The Petroleum Clinical Medical College of Hebei Medical University, Langfang, Hebei 065000, P.R. China
  • Pages: 4745-4752
    |
    Published online on: September 27, 2018
       https://doi.org/10.3892/etm.2018.6799
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was investigate the association of the severity of emphysema of patients with chronic obstructive pulmonary disease (COPD) with airway inflammation and the COPD‑specific comorbidity test (COTE) index. A total of 94 patients with COPD were divided into four groups according to the severity of their emphysema; in each patient, comorbidities were recorded and inflammatory biomarkers, including MMP‑9 and TIMP‑1 were determined in circulating blood. The unbalanced proportion of MMP‑9 and its inhibitor, TIMP‑1, led to the airway inflammation and lung remodeling in the patients with COPD. A total of 80.85% of the patients had emphysema of different degrees. The quantity of male patients and the smoking index in the three emphysema groups were significantly higher than those in the non‑emphysema group (F=7.67 and 5.42, P<0.05). The level of the predicted percent offorced expiratory volume in 1 sec in the non‑emphysema group were significantly higher than those in the emphysema group (4.33; P<0.05), and the level of D‑dimer in the non‑emphysema group was significantly lower than that in the mild and moderate emphysema groups (F=9.38, P<0.05). The low‑attenuation area score was negatively correlated with inhaled bronchodilators (r=‑0.240, P=0.007) but positively correlated with the frequency of acute exacerbations in the previous year (r=0.211, P=0.001). In terms of treatment, the use of systemic hormone therapy in the emphysema group was more frequent than that in the non‑emphysema group (F=6.21, 12.92 and 4.08, P<0.05). The level of MMP‑9 was significantly higher in COPD patients with >3 comorbidities, a COTE index of ≥4 and cardiovascular disease as well as coronary heart disease (t=6.40, 2.53, 3.65 and 2.90, P<0.05). The level of MMP‑9 was positively correlated with the neutrophilic granulocyte percentage, the number of comorbidities and the COTE index (r=0.193, 0.402 and 0.311, P<0.01). The severity of emphysema in patients with COPD was correlated with the persistence of inflammatory factors in the circulating blood and the frequency of acute exacerbations. It was indicated that MMP‑9 has a critical role in numerous comorbidities of COPD.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ostridge K, Williams N, Kim V, Harden S, Bourne S, Coombs NA, Elkington PT, Estepar RS, Washko G, Staples KJ and Wilkinson TM: Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. Respir Res. 17:922016. View Article : Google Scholar : PubMed/NCBI

2 

Papakonstantinou E, Karakiulakis G, Batzios S, Savic S, Roth M, Tamm M and Stolz D: Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection. Respir Res. 16:782015. View Article : Google Scholar : PubMed/NCBI

3 

Smith BM, Austin JH, Newell JD Jr, D'Souza BM, Rozenshtein A, Hoffman EA, Ahmed F and Barr RG: Pulmonary emphysema subtypes on computed tomography: The MESA COPD study. Am J Med. 127:94.e7–e23. 2014. View Article : Google Scholar

4 

Foster WL Jr, Pratt PC, Roggli VL, Godwin JD, Halvorsen RA Jr and Putman CE: Centrilobular emphysema: CT-pathologic correlation. Radiology. 159:27–32. 1986. View Article : Google Scholar : PubMed/NCBI

5 

Hruban RH, Meziane MA, Zerhouni EA, Khouri NF, Fishman EK, Wheeler PS, Dumler JS and Hutchins GM: High resolution computed tomography of inflation-fixed lungs. Pathologic-radiologic correlation of centrilobular emphysema. Am Rev Respir Dis. 136:935–940. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Montaño M, Sansores RH, Becerril C, Cisneros J, González-Avila G, Sommer B, Ochoa L, Herrera I, Ramírez-Venegas A and Ramos C: FEV1 inversely correlates with metalloproteinases 1, 7, 9 and CRP in COPD by biomass smoke exposure. Respir Res. 15:742014.PubMed/NCBI

7 

Grzela K, Litwiniuk M, Zagorska W and Grzela T: Airway remodeling in chronic obstructive pulmonary disease and asthma: The role of matrix metalloproteinase-9. Arch Immunol Ther Exp (Warsz). 64:47–55. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Jia TG, Zhao JQ and Liu JH: Serum inflammatory factor and cytokines in AECOPD. Asian Pac J Trop Med. 7:1005–1008. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Divo M, Cote C, de Torres JP, Casanova C, Marin JM, Pinto-Plata V, Zulueta J, Cabrera C, Zagaceta J, Hunninghake G, et al: Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 186:155–161. 2002. View Article : Google Scholar

10 

Celli BR and MacNee W; ATS/ERS Task Force, : Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper. Eur Respir J. 23:932–946. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Kitaguchi Y, Fujimoto K, Kubo K and Honda T: Characteristics of COPD phenotypes classified according to the findings of HRCT. Respir Med. 100:1742–1752. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Roberts HR, Wells AU, Milne DG, Rubens MB, Kolbe J, Cole PJ and Hansell DM: Airflow obstruction in bronchiectasis: Correlation between computed tomography features and pulmonary function tests. Thorax. 55:198–204. 2000. View Article : Google Scholar : PubMed/NCBI

13 

The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis. 132:182–185. 1985.PubMed/NCBI

14 

Hoffman EA, Simon BA and Mclennan G: State of the art. A structural and functional assessment of the lung via multidetector-row computed tomography: Phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc. 3:519–532. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Singh S, Loke YK, Enright PL and Furberg CD: Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of randomised controlled trials. BMJ. 342:d32152011. View Article : Google Scholar : PubMed/NCBI

16 

Dar KA, Shahid M, Mubeen A, Bhargava R, Ahmad Z, Ahmad I and Islam N: The role of noninvasive methods in assessing airway inflammation and structural changes in asthma and COPD. Monaldi Arch Chest Dis. 77:8–18. 2012.PubMed/NCBI

17 

Kwiatkowska S, Noweta K, Zieba M, Nowak D and Bialasiewicz P: Enhanced exhalation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with COPD exacerbation: A prospective study. Respiration. 84:231–241. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Linder R, Rönmark E, Pourazar J, Behndig A, Blomberg A and Lindberg A: Serum metallopteinase-9 is related to COPD severity and symptoms-cross-sectional data from a population based cohort-study. Respir Res. 16:282015. View Article : Google Scholar : PubMed/NCBI

19 

Anderson AE Jr and Foraker AG: Centrerilobolar emphysema and panlobular emphysema: Two different diseases. Thorax. 28:547–550. 1973. View Article : Google Scholar : PubMed/NCBI

20 

Saetta M, Kim WD, Izquierdo JL, Ghezzo H and Cosio MG: Extent of centriobular and panacinar emphysema in smokers'lungs: Pathological and mechanical implications. Eur Respir J. 7:664–671. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Kawayama T, Kinoshita T, Matsunaga K, Kobayashi A, Hayamizu T, Johnson M and Hoshino T: Responsiveness of blood and sputum inflammatory cells in Japanese copd patients, non-copd smoking controls, and non-copd nonsmoking controls. Int J Chron Obstruct Pulmon Dis. 11:295–303. 2016.PubMed/NCBI

22 

Segura-Valdezl L, Pardo A, Gaxiola M, Uhal BD, Becerril C and Selman M: Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest. 117:684–694. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Linder R, Rönmark E, Pourazar J, Behndig A, Blomberg A and Lindberg A: Serum metalloproteinase-9 is related to COPD severity and symptoms-cross-sectional data from a population based cohort-study. Respir Res. 16:282015. View Article : Google Scholar : PubMed/NCBI

24 

Hong Y, Ji W, An S, Han SS, Lee SJ and Kim WJ: Sex differences of COPD phenotypes in nonsmoking patiens. Int J Chron Obstruct Pulmon Dis. 11:1657–1662. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Kim V, Han MK, Vance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK and Criner GJ; COPDGene Investigators, : The chronic bronchitic phenotype of COPD: An analysis of the COPDGene study. Chest. 140:626–633. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Smith MC and Wrobel JP: Epidemiology and clinical impact of major comorbidities in patients with COPD. Int J Chron Obstruct Pulmon Dis. 9:871–888. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Selvarajah S, Todd I, Tighe PJ, John M, Bolton CE, Harrison T and Fairclough LC: Multiple Circulating cytokines are coelevated in chronic obstrictive pulmonary disease. Mediators Inflamm. 2016:36048422016. View Article : Google Scholar : PubMed/NCBI

28 

Eickhoff P, Valipour A, Kiss D, Schreder M, Cekici L, Geyer K, Kohansal R and Burghuber OC: Determinants of systemic vascular function in patients wity stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 178:1211–1218. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, et al: Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl Med. 367:913–921. 2012. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Shi F, Liu JX, Gao CL, Pei MM, Li J and Li PX: Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index. Exp Ther Med 16: 4745-4752, 2018.
APA
Liu, Z., Shi, F., Liu, J., Gao, C., Pei, M., Li, J., & Li, P. (2018). Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index. Experimental and Therapeutic Medicine, 16, 4745-4752. https://doi.org/10.3892/etm.2018.6799
MLA
Liu, Z., Shi, F., Liu, J., Gao, C., Pei, M., Li, J., Li, P."Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index". Experimental and Therapeutic Medicine 16.6 (2018): 4745-4752.
Chicago
Liu, Z., Shi, F., Liu, J., Gao, C., Pei, M., Li, J., Li, P."Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4745-4752. https://doi.org/10.3892/etm.2018.6799
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Shi F, Liu JX, Gao CL, Pei MM, Li J and Li PX: Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index. Exp Ther Med 16: 4745-4752, 2018.
APA
Liu, Z., Shi, F., Liu, J., Gao, C., Pei, M., Li, J., & Li, P. (2018). Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index. Experimental and Therapeutic Medicine, 16, 4745-4752. https://doi.org/10.3892/etm.2018.6799
MLA
Liu, Z., Shi, F., Liu, J., Gao, C., Pei, M., Li, J., Li, P."Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index". Experimental and Therapeutic Medicine 16.6 (2018): 4745-4752.
Chicago
Liu, Z., Shi, F., Liu, J., Gao, C., Pei, M., Li, J., Li, P."Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4745-4752. https://doi.org/10.3892/etm.2018.6799
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team