Open Access

Comparison of clinical efficacy of metoprolol combinedwith irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure

  • Authors:
    • Fangxia Zhang
    • Guoxia Zhou
    • Lisha Guo
    • Fei Lu
    • Guojun Zhou
  • View Affiliations

  • Published online on: October 4, 2018     https://doi.org/10.3892/etm.2018.6828
  • Pages: 5059-5066
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure (HF) was investigated. A retrospective analysis of the medical records of 124 patients with severe HF admitted to Binzhou Medical University Hospital from May 2012 to August 2016 was performed. Among them, 78 patients who were treated with metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator for emergency treatment were enrolled into the Research Group, while the Control Group consisted of 46 patients treated with routine medical treatment. Echocardiographic parameters, 6-minute walking test results, the efficacy of the emergency treatment, cardiac function grading, left ventricular ejection fraction (LVEF) and brain natriuretic peptide (BNP) levels were compared between the two groups. After the emergency treatment, the echocardiographic indexes of both groups increased to different extents (P<0.05). Compared with the results before, patients of both groups walked longer within six minutes after the emergency treatment (P<0.05). After the emergency treatment, the BNP expression levels in the two groups decreased to different degrees (P<0.05). After a 7-day emergency treatment, the efficiency rate of treatment of the Research Group was higher than that of the Control Group (P<0.05). The method is helpful for the recovery of respiratory function, for relieving symptoms in short time, improving cardiac function and promising high safety, using metoprolol and irbesartan and hydrochlorothiazide combined with non-invasive ventilator had satisfactory clinical efficacy in the emergency treatment of patients with severe heart failure and is thus worthy of clinical promotion.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang F, Zhou G, Guo L, Lu F and Zhou G: Comparison of clinical efficacy of metoprolol combinedwith irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure. Exp Ther Med 16: 5059-5066, 2018
APA
Zhang, F., Zhou, G., Guo, L., Lu, F., & Zhou, G. (2018). Comparison of clinical efficacy of metoprolol combinedwith irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure. Experimental and Therapeutic Medicine, 16, 5059-5066. https://doi.org/10.3892/etm.2018.6828
MLA
Zhang, F., Zhou, G., Guo, L., Lu, F., Zhou, G."Comparison of clinical efficacy of metoprolol combinedwith irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure". Experimental and Therapeutic Medicine 16.6 (2018): 5059-5066.
Chicago
Zhang, F., Zhou, G., Guo, L., Lu, F., Zhou, G."Comparison of clinical efficacy of metoprolol combinedwith irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5059-5066. https://doi.org/10.3892/etm.2018.6828