Open Access

Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta‑analysis

  • Authors:
    • Wenjun Geng
    • Jianhua Zhao
    • Jixing Fu
    • Huamin Zhang
    • Shaohua Qiao
  • View Affiliations

  • Published online on: October 15, 2018     https://doi.org/10.3892/etm.2018.6859
  • Pages: 5085-5095
  • Copyright: © Geng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present meta‑analysis was to systematically assess the efficacy of the various treatments available for moderate to severe psoriasis. PubMed and Embase databases were systematically searched to select relevant studies up to February 2015. Odds ratios (ORs) and their 95% confidence intervals (CIs) were used as effect estimates. In addition, the Psoriasis Area and Severity Index (PASI) 50, PASI 75 and PASI 90 responses for the therapies were systematically assessed. A total of 33 randomized controlled trials were included in the present study. For the PASI 75 response rate, infliximab (5 mg) may be the most effective option for the treatment of moderate to severe psoriasis. Furthermore, the pooled results of the PASI 50 response rate demonstrated that infliximab (5 mg) and ustekinumab (90 mg) may be superior to other drugs for treating moderate to severe psoriasis. For the PASI 90 response rate, infliximab (5 mg), ustekinumab (90 mg) and briakinumab (weeks 0 and 4, 200 mg; week 8, 100 mg) exhibited improved results compared with other treatments. In conclusion, infliximab (5 mg) may be a superior option to treat moderate to severe psoriasis due to the relatively high PASI scores. However, despite the high PASI 90 responses, further studies are required to identify the efficacy of ustekinumab (90 mg) and briakinumab.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Geng W, Zhao J, Fu J, Zhang H and Qiao S: Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta‑analysis. Exp Ther Med 16: 5085-5095, 2018
APA
Geng, W., Zhao, J., Fu, J., Zhang, H., & Qiao, S. (2018). Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta‑analysis. Experimental and Therapeutic Medicine, 16, 5085-5095. https://doi.org/10.3892/etm.2018.6859
MLA
Geng, W., Zhao, J., Fu, J., Zhang, H., Qiao, S."Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta‑analysis". Experimental and Therapeutic Medicine 16.6 (2018): 5085-5095.
Chicago
Geng, W., Zhao, J., Fu, J., Zhang, H., Qiao, S."Efficacy of several biological therapies for treating moderate to severe psoriasis: A network meta‑analysis". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5085-5095. https://doi.org/10.3892/etm.2018.6859