Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation

  • Authors:
    • Lili Zhong
    • Hong Liu
    • Weijia Zhang
    • Xu Liu
    • Bo Jiang
    • Hongxin Fei
    • Zhongren Sun
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China, Postdoctoral Program, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Second Department of Orthopedic Surgery, Harbin First Hospital, Harbin, Heilongjiang 150010, P.R. China, Experimental Center, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China, Department of Pathology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China, Key Laboratory of Acupuncture Clinical Neurobiology (Encephalopathy), Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4951-4958
    |
    Published online on: October 15, 2018
       https://doi.org/10.3892/etm.2018.6860
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

β‑amyloid (Aβ) aggregation and tau hyperphosphorylation are considered to be the primary pathological hallmarks of Alzheimer's disease (AD). Targeted inhibition of these pathological processes may provide effective treatments for AD. Accumulating evidence has demonstrated that ellagic acid (EA) exerts neuroprotective effects in several diseases. The present study investigated the effects of EA on AD‑associated learning and memory deficits on APP/PS1 double transgenic mice and the underlying mechanisms. APP/PS1 mice or wild‑type C57BL/6 mice were intragastrically administered EA (50 mg/kg/day) or vehicle for 60 consecutive days. The learning and memory abilities of mice were investigated using the Morris water maze test. Hippocampal regions were examined for the presence of amyloid plaques, neuronal apoptosis and tau phosphorylation. Expression levels of APP, Aβ, RAC‑αserine/threonine‑protein kinase and glycogen synthase kinase (GSK)3β in the hippocampus were determined by western blot analysis and ELISA. The results demonstrated that EA treatment ameliorated spatial learning and memory impairment in APP/PS1 mice and significantly reduced neuronal apoptosis and Aβ deposition in the hippocampus (P<0.05 and P<0.01). In addition, EA significantly inhibited the hyperphosphorylation of tau and significantly decreased the activity of glycogen synthase kinase (GSK)3β (P<0.01), which is involved in tau phosphorylation. Overall, these findings indicated that the beneficial effects of EA on AD‑associated cognitive impairments may be attributed to the inhibition of Aβ production and tau hyperphosphorylation, and its beneficial action may be mediated in part, by the RAC‑α serine/threonine‑protein kinase/GSK3β signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D and Jones E: Alzheimer's disease. Lancet. 377:1019–1031. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Selkoe DJ: Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis. 3:75–80. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Nelson PT, Braak H and Markesbery WR: Neuropathology and cognitive impairment in Alzheimer disease: A complex but coherent relationship. J Neuropathol Exp Neurol. 68:1–14. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Bloom GS: Amyloid-β and tau: The trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 71:505–508. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Ruan YY, Zhai W, Shi XM, Zhang L and Hu YL: Safflower yellow ameliorates cognition deficits and reduces tau phosphorylation in APP/PS1 transgenic mice. Metab Brain Dis. 31:1133–1142. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Sobów T, Flirski M and Liberski PP: Amyloid-beta and tau proteins as biochemical markers of Alzheimer's disease. Acta Neurobiol Exp (Wars). 64:53–70. 2004.PubMed/NCBI

7 

Sengupta U, Nilson AN and Kayed R: The role of Amyloid-β oligomers in toxicity, propagation, and immunotherapy. EBioMedicine. 6:42–49. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhang B, Li Q, Chu X, Sun S and Chen S: Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer's disease. Transl Neurodegener. 5:212016. View Article : Google Scholar : PubMed/NCBI

9 

Amakura Y, Okada M, Tsuji S and Tonogai Y: High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. J Chromatogr A. 896:87–93. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Han DH, Lee MJ and Kim JH: Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Res. 26:3601–3606. 2006.PubMed/NCBI

11 

Mansouri MT, Hemmati AA, Naghizadeh B, Mard SA, Rezaie A and Ghorbanzadeh B: A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian J Pharmacol. 47:292–298. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Ahmed T, Setzer WN, Nabavi SF, Orhan IE, Braidy N, Sobarzo-Sanchez E and Nabavi SM: Insights into effects of ellagic acid on the nervous system: A mini review. Curr Pharm Des. 22:1350–1360. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Farbood Y, Sarkaki A, Dianat M, Khodadadi A, Haddad MK and Mashhadizadeh S: Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury. Life Sci. 124:120–127. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Sarkaki A, Farbood Y, Dolatshahi M, Mansouri SM and Khodadadi A: Neuroprotective effects of ellagic acid in a rat model of Parkinson's disease. Acta Med Iran. 54:494–502. 2016.PubMed/NCBI

15 

Feng Y, Yang SG, Du XT, Zhang X, Sun XX, Zhao M, Sun GY and Liu RT: Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity. Biochem Biophys Res Commun. 390:1250–1254. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Kiasalari Z, Heydarifard R, Khalili M, Afshin-Majd S, Baluchnejadmojarad T, Zahedi E, Sanaierad A and Roghani M: Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer's disease: An exploration of underlying mechanisms. Psychopharmacology (Berl). 234:1841–1852. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Baluchnejadmojarad T, Rabiee N, Zabihnejad S and Roghani M: Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson's disease: Possible involvement of ERbeta/Nrf2/HO-1 signaling. Brain Res. 1662:23–30. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Zhang ZX, Zhao RP, Wang DS and Wang AN: Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11 month old APP/PS1 transgenic mice: A Western blot study. Exp Gerontol. 84:88–95. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ and Lee VM: Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 53:337–351. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ma J, Gao Y, Jiang L, Chao FL, Huang W, Zhou CN, Tang W, Zhang L, Huang CX, Zhang Y, et al: Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice. Oncotarget. 8:27676–27692. 2017.PubMed/NCBI

21 

Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ and Frosch MP: Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 24:516–524. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Niikura T, Tajima H and Kita Y: Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin. Curr Neuropharmacol. 4:139–147. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Mucke L: Neuroscience: Alzheimer's disease. Nature. 461:895–897. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Jahn H: Memory loss in Alzheimer's disease. Dialogues Clin Neurosci. 15:445–454. 2013.PubMed/NCBI

25 

Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK and Tsai LH: APP processing is regulated by cytoplasmic phosphorylation. J Cell Biol. 163:83–95. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Gandhi S, Refolo LM and Sambamurti K: Amyloid precursor protein compartmentalization restricts beta-amyloid production: Therapeutic targets based on BACE compartmentalization. J Mol Neurosci. 24:137–143. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Kurt MA, Davies DC, Kidd M, Duff K and Howlett DR: Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol Dis. 14:89–97. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Cohen P and Frame S: The renaissance of GSK3. Nat Rev Mol Cell Biol. 2:769–776. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Sabbagh M and Cummings J: Progressive cholinergic decline in Alzheimer's disease: Consideration for treatment with donepezil 23 mg in patients with moderate to severe symptomatology. BMC Neurol. 11:212011. View Article : Google Scholar : PubMed/NCBI

30 

Serrano-Pozo A, Frosch MP, Masliah E and Hyman BT: Neuropathological alterations in Alzheimer disease. Cold Spring Harbor Persp Med. 1:a0061892011.

31 

Parthsarathy V, McClean PL, Hölscher C, Taylor M, Tinker C, Jones G, Kolosov O, Salvati E, Gregori M, Masserini M and Allsop D: A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1DeltaE9 mouse model of Alzheimer's disease. PLoS One. 8:e547692013. View Article : Google Scholar : PubMed/NCBI

32 

Herran E, Perez-Gonzalez R, Igartua M, Pedraz JL, Carro E and Hernandez RM: Enhanced Hippocampal Neurogenesis in APP/Ps1 Mouse Model of Alzheimer's Disease After Implantation of VEGF-loaded PLGA Nanospheres. Curr Alzheimer Res. 12:932–940. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Reiserer RS, Harrison FE, Syverud DC and McDonald MP: Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav. 6:54–65. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Dionísio PA, Amaral JD, Ribeiro MF, Lo AC, D'Hooge R and Rodrigues CM: Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset. Neurobiol Aging. 36:228–240. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H and Zhang D: FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation. PloS One. 8:e780332013. View Article : Google Scholar : PubMed/NCBI

36 

Li C, Guo XD, Lei M, Wu JY, Jin JZ, Shi XF, Zhu ZY, Rukachaisirikul V, Hu LH, Wen TQ and Shen X: Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies. Acta Pharmacol Sin. 38:9–28. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Chang KA, Kim HS, Ha TY, Ha JW, Shin KY, Jeong YH, Lee JP, Park CH, Kim S, Baik TK and Suh YH: Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol Cell Biol. 26:4327–4338. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Taghavi F, Habibi-Rezaei M, Bohlooli M, Farhadi M, Goodarzi M, Movaghati S, Maghami P, Taghibiglou C, Amanlou M, Haertlé T and Moosavi-Movahedi AA: Antiamyloidogenic effects of ellagic acid on human serum albumin fibril formation induced by potassium sorbate and glucose. J Mol Recognit. 29:611–618. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ and Mucke L: Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 316:750–754. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, et al: Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta. 1739:198–210. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Ma Q, Ruan YY, Xu H, Shi XM, Wang ZX and Hu YL: Safflower yellow reduces lipid peroxidation, neuropathology, tau phosphorylation and ameliorates amyloid beta-induced impairment of learning and memory in rats. Biomed Pharmacother. 76:153–164. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Maas T, Eidenmüller J and Brandt R: Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem. 275:15733–15740. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Matsuoka Y, Gray AJ, Hirata-Fukae C, Minami SS, Waterhouse EG, Mattson MP, LaFerla FM, Gozes I and Aisen PS: Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci. 31:165–170. 2007.PubMed/NCBI

44 

Ryder J, Su Y and Ni B: Akt/GSK3beta serine/threonine kinases: Evidence for a signalling pathway mediated by familial Alzheimer's disease mutations. Cell Signal. 16:187–200. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Gassowska M, Czapski GA, Pajak B, Cieslik M, Lenkiewicz AM and Adamczyk A: Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells. PloS One. 9:e942592014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhong L, Liu H, Zhang W, Liu X, Jiang B, Fei H and Sun Z: Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation. Exp Ther Med 16: 4951-4958, 2018.
APA
Zhong, L., Liu, H., Zhang, W., Liu, X., Jiang, B., Fei, H., & Sun, Z. (2018). Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation. Experimental and Therapeutic Medicine, 16, 4951-4958. https://doi.org/10.3892/etm.2018.6860
MLA
Zhong, L., Liu, H., Zhang, W., Liu, X., Jiang, B., Fei, H., Sun, Z."Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation". Experimental and Therapeutic Medicine 16.6 (2018): 4951-4958.
Chicago
Zhong, L., Liu, H., Zhang, W., Liu, X., Jiang, B., Fei, H., Sun, Z."Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4951-4958. https://doi.org/10.3892/etm.2018.6860
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong L, Liu H, Zhang W, Liu X, Jiang B, Fei H and Sun Z: Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation. Exp Ther Med 16: 4951-4958, 2018.
APA
Zhong, L., Liu, H., Zhang, W., Liu, X., Jiang, B., Fei, H., & Sun, Z. (2018). Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation. Experimental and Therapeutic Medicine, 16, 4951-4958. https://doi.org/10.3892/etm.2018.6860
MLA
Zhong, L., Liu, H., Zhang, W., Liu, X., Jiang, B., Fei, H., Sun, Z."Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation". Experimental and Therapeutic Medicine 16.6 (2018): 4951-4958.
Chicago
Zhong, L., Liu, H., Zhang, W., Liu, X., Jiang, B., Fei, H., Sun, Z."Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4951-4958. https://doi.org/10.3892/etm.2018.6860
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team