Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication

  • Authors:
    • Xiaoqiu Jin
    • Ying Zhu
    • Yingchun Zhang
    • Jing Chen
    • Li Rong
    • Xuesong Zhao
  • View Affiliations / Copyright

    Affiliations: Teaching and Research Office of Pediatrics, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Pediatrics, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Clinical Laboratory, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Pediatrics, The First Hospital of Qiqihar City, Qiqihar, Heilongjiang 161006, P.R. China, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5025-5030
    |
    Published online on: October 17, 2018
       https://doi.org/10.3892/etm.2018.6873
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Levels of D‑dimer and interferon‑γ (INF‑γ) in pediatric patients with Mycoplasma pneumoniae pneumonia (MPP) were assessed to explore its clinical implication in evaluating the disease severity and patients' prognosis. Enrolled in this study as subjects were 185 pediatric patients with MPP who were admitted to the Department of Pediatrics of the Second Affiliated Hospital of Qiqihar Medical University and the First Hospital of Qiqihar City from January 2017 to October 2017 and 115 healthy children who underwent physical examination during the same time period. Patients were divided into two groups according to the severity of their pneumonia: Severe pneumonia group with 95 patients and mild pneumonia group with 90 patients. A total of 92 healthy children were assigned to the control group. Immunoassay was performed to measure the serum levels of D‑dimer and INF‑γ. The levels of these two markers were compared. In terms of D‑dimer, the levels in pediatric patients in pneumonia groups were all higher than that in the healthy children (p<0.0001). After treatment for 120 h, the D‑dimer and INF‑γ levels in both pneumonia groups were lower than those before treatment (p<0.001). Among the patients in both the mild and severe pneumonia groups, those who developed extra‑pulmonary complications had higher levels of D‑dimer and INF‑γ than those who did not developed extra‑pulmonary complications (p<0.001). Increased levels of D‑dimer and INF‑γ were observed in pediatric patients with MPP. Assessment of the levels of D‑dimer and INF‑γ in serum may help with the diagnosis of severe MPP in children and predicting the occurrence of complications. This study provided more theoretical basis for the early diagnosis and identification of MPP in children, and can be used as a guideline in evaluating the severity and preventing complications.
View Figures

Figure 1

Figure 2

View References

1 

Leong CL, Norazah A, Azureen A and Lingam R: Community-acquired necrotising pneumonia caused by Panton-Valentine leucocidin-producing methicillin-resistant Staphylococcus aureus. Med J Malaysia. 72:378–379. 2017.PubMed/NCBI

2 

Tashiro M, Fushimi K, Kawano K, Takazono T, Saijo T, Yamamoto K, Kurihara S, Imamura Y, Miyazaki T, Yanagihara K, et al: Adjunctive corticosteroid therapy for inpatients with Mycoplasma pneumoniae pneumonia. BMC Pulm Med. 17:2192017. View Article : Google Scholar : PubMed/NCBI

3 

Qiu L, Wang L, Tan L, Li M, Wu C, Li L, Zhang Z, Jiang H, Sun Q and Zhang T: Molecular characterization of genomic DNA in Mycoplasma pneumoniae strains isolated from serious mycoplasma pneumonia cases in 2016, Yunnan, China. Infect Genet Evol. 58:125–134. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Millot G, Voisin B, Loiez C, Wallet F and Nseir S: The next generation of rapid point-of-care testing identification tools for ventilator-associated pneumonia. Ann Transl Med. 5:4512017. View Article : Google Scholar : PubMed/NCBI

5 

Li YX, Zheng ZG, Liu N, Wang XN, Wu LL and Chen RC: Risk factors for pulmonary embolism in acute exacerbation of chronic obstructive pulmonary disease. Zhonghua Jie He He Hu Xi Za Zhi. 39:298–303. 2016.(In Chinese). PubMed/NCBI

6 

Imdad A, Mayo-Wilson E, Herzer K and Bhutta ZA: Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev. 3:CD0085242017.PubMed/NCBI

7 

Zhang Y, Zhou X, Zhang H, Huan C and Ye Z: Establishment of Acinetobacter baumannii-induced pneumonia model in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 33:1392–1397. 2017.(In Chinese). PubMed/NCBI

8 

Miyashita N, Obase Y, Ouchi K, Kawasaki K, Kawai Y, Kobashi Y and Oka M: Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit. J Med Microbiol. 56:1625–1629. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Li MS, Hung GC, Yang SY, Pan CH, Liao YT, Tsai SY, Chen CC and Kuo CJ: Excess incidence and risk factors for recurrent pneumonia in bipolar disorder. Psychiatry Clin Neurosci. 72:337–348. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Li W, Ding C and Yin S: Aging increases the expression of lung CINCs and MCP-1 in senile patients with pneumonia. Oncotarget. 8:108604–108609. 2017.PubMed/NCBI

11 

Minz A, Agarwal M, Singh JV and Singh VK: Care seeking for childhood pneumonia by rural and poor urban communities in Lucknow: A community-based cross-sectional study. J Family Med Prim Care. 6:211–217. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Yin YD, Wang R, Zhuo C, Wang H, Wang MG, Xie CM, She DY, Yuan X, Wang RT, Cao B, et al: Macrolide-resistant Mycoplasma pneumoniae prevalence and clinical aspects in adult patients with community-acquired pneumonia in China: A prospective multicenter surveillance study. J Thorac Dis. 9:3774–3781. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Joob B and Wiwanitkit V: Leukoagglutination, Mycoplasma pneumoniae pneumonia and EDTA acid blood. Turk J Haematol. 35:75–76. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Parois SP, Faoüen A, Le Floc'h N and Prunier A: Influence of the inflammatory status of entire male pigs on their pubertal development and fat androstenone. Animal. 11:1071–1077. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Ye Q, Xu XJ, Shao WX, Pan YX and Chen XJ: Mycoplasma pneumoniae infection in children is a risk factor for developing allergic diseases. ScientificWorldJournal. 2014:9865272014. View Article : Google Scholar : PubMed/NCBI

16 

Jiang YL and Peng DH: Serum level of vitamin A in children with pneumonia aged less than 3 years. Zhongguo Dang Dai Er Ke Za Zhi. 18:980–983. 2016.(In Chinese). PubMed/NCBI

17 

Wu HB, Ma WG, Zhao HL, Zheng J, Li JR, Liu O and Sun LZ: Risk factors for continuous renal replacement therapy after surgical repair of type A aortic dissection. J Thorac Dis. 9:1126–1132. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Yuan SJ, Xie HT and Li ZL: Clinical significance of hypersensitive C-reactive protein, fribrinogen and D-dimmer in connective tissue disease-related interstitial lung disease. Nan Fang Yi Ke Da Xue Xue Bao. 37:415–419. 2017.(In Chinese). PubMed/NCBI

19 

Duarte T, Barbisan F, do Prado-Lima PAS, Azzolin VF, da Cruz Jung IE, Duarte MMMF, Teixeira CF, Mastella MH and da Cruz IBM: Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro. Cytokine. 106:101–107. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Xu J, Gu Y, Sun J, Zhu H, Lewis DF and Wang Y: Reduced CD200 expression is associated with altered Th1/Th2 cytokine production in placental trophoblasts from preeclampsia. Am J Reprod Immunol. 79:e127632018. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jin X, Zhu Y, Zhang Y, Chen J, Rong L and Zhao X: Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication. Exp Ther Med 16: 5025-5030, 2018.
APA
Jin, X., Zhu, Y., Zhang, Y., Chen, J., Rong, L., & Zhao, X. (2018). Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication. Experimental and Therapeutic Medicine, 16, 5025-5030. https://doi.org/10.3892/etm.2018.6873
MLA
Jin, X., Zhu, Y., Zhang, Y., Chen, J., Rong, L., Zhao, X."Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication". Experimental and Therapeutic Medicine 16.6 (2018): 5025-5030.
Chicago
Jin, X., Zhu, Y., Zhang, Y., Chen, J., Rong, L., Zhao, X."Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5025-5030. https://doi.org/10.3892/etm.2018.6873
Copy and paste a formatted citation
x
Spandidos Publications style
Jin X, Zhu Y, Zhang Y, Chen J, Rong L and Zhao X: Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication. Exp Ther Med 16: 5025-5030, 2018.
APA
Jin, X., Zhu, Y., Zhang, Y., Chen, J., Rong, L., & Zhao, X. (2018). Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication. Experimental and Therapeutic Medicine, 16, 5025-5030. https://doi.org/10.3892/etm.2018.6873
MLA
Jin, X., Zhu, Y., Zhang, Y., Chen, J., Rong, L., Zhao, X."Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication". Experimental and Therapeutic Medicine 16.6 (2018): 5025-5030.
Chicago
Jin, X., Zhu, Y., Zhang, Y., Chen, J., Rong, L., Zhao, X."Assessment of levels of D‑dimer and interferon‑γ in pediatric patients with Mycoplasma pneumoniae pneumonia and its clinical implication". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5025-5030. https://doi.org/10.3892/etm.2018.6873
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team