Open Access

Gastric calcifying fibrous tumor: A clinicopathological study of nine cases

  • Authors:
    • Shan Tian
    • Zhi Zeng
    • Xiulan Peng
    • Weiguo Dong
  • View Affiliations

  • Published online on: October 23, 2018     https://doi.org/10.3892/etm.2018.6892
  • Pages: 5137-5143
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to analyze the clinicopathological characteristics presented in 9 cases of gastric calcifying fibrous tumor (CFT), and investigate the expressions and clinical implications of G protein‑coupled estrogen receptor (GPER), estrogen receptor (ER) and vimentin in gastric CFTs. The clinical and pathological information of 9 patients with CFTs was investigated retrospectively. Subsequently, the expression of GPER, ER and vimentin were examined using immunohistochemistry, and a literature search for gastric CFT was conducted. The 9 patients were 40‑71 years old with a mean age of 52.22 years, including 6 female and 3 male patients. Pathological features included dense hyalinized collagen fibers with a psammomatous body or dystrophic calcification, and the infiltration of scattered lymphocytes and plasma cells. Immunohistochemically, all cases expressed vimentin and GPER, whereas ER expression was negative. Using a database research, 25 studies regarding gastric CFT were identified, including 48 cases with a sex ratio (female:male) of 1.4:1. In addition, the number of female patients was twice the number of male patients in patients <50 years old, whereas the number was almost equal between women and men ≥50 years of age. Gastric CFT is a benign lesion with a good prognosis and a predilection for female patients, particularly premenopausal women. Estrogen may serve a role in this female predominance, and this may be mediated by GPER rather than ER.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tian S, Zeng Z, Peng X and Dong W: Gastric calcifying fibrous tumor: A clinicopathological study of nine cases. Exp Ther Med 16: 5137-5143, 2018
APA
Tian, S., Zeng, Z., Peng, X., & Dong, W. (2018). Gastric calcifying fibrous tumor: A clinicopathological study of nine cases. Experimental and Therapeutic Medicine, 16, 5137-5143. https://doi.org/10.3892/etm.2018.6892
MLA
Tian, S., Zeng, Z., Peng, X., Dong, W."Gastric calcifying fibrous tumor: A clinicopathological study of nine cases". Experimental and Therapeutic Medicine 16.6 (2018): 5137-5143.
Chicago
Tian, S., Zeng, Z., Peng, X., Dong, W."Gastric calcifying fibrous tumor: A clinicopathological study of nine cases". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5137-5143. https://doi.org/10.3892/etm.2018.6892