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Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty

  • Authors:
    • Zhi-Jun Zhou
    • Jian Tang
    • Wei-Hua Li
    • Wei-Dong Tao
  • View Affiliations / Copyright

    Affiliations: The Second People's Hospital of Nantong, Nantong, Jiangsu 226002, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 354-358
    |
    Published online on: October 31, 2018
       https://doi.org/10.3892/etm.2018.6911
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Abstract

Effect of flurbiprofen on the postoperative cognition and inflammatory cytokines in elderly patients after hip arthroplasty was investigated. Elderly patients undergoing replacement of total hip were randomly divided into three groups of equal size (n=60). A control group (control) received no treatment before or at the end of surgery. The other two groups, PRE and INTRA, received 50 mg flurbiprofen intravenously 15 min before the surgery and 30 min before the end of surgery, respectively. The pain score was evaluated by a visual analog scale (VAS) at the following time-points: 24 h before surgery (T0), and 3 h (T1), 12 h (T2) and 24 h (T3) after surgery. Peripheral venous blood was collected at T0, T1, T2 and T3. Cognitive function was assessed by mini-mental state examination (MMSE) at the time of T0, T1, T2 and T3. The serum concentration of tumor necrosis factor α (TNF‑α), interleukin-1β (IL-1β), IL-6, and Cox-2 were measured using enzyme linked immunosorbent assay (ELISA). The VAS scores and the release of pro-inflammatory cytokines in the PRE and INTRA groups were less than those in the control group at T1, T2 and T3. The MMSE scores in PRE and INTRA groups were significantly higher than those in the control group at T1, T2 and T3. The PRE group showed a lower VAS score, release of pro-inflammatory cytokines and higher MMSE scores at T1, T2 and T3 than the control and INTRA groups. Intravenous flurbiprofen administration reduces postoperative pain and flammatory response after hip arthroplasty. Moreover, flurbiprofen is more effective when given preoperatively than intraoperatively.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou Z, Tang J, Li W and Tao W: Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty. Exp Ther Med 17: 354-358, 2019.
APA
Zhou, Z., Tang, J., Li, W., & Tao, W. (2019). Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty. Experimental and Therapeutic Medicine, 17, 354-358. https://doi.org/10.3892/etm.2018.6911
MLA
Zhou, Z., Tang, J., Li, W., Tao, W."Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty". Experimental and Therapeutic Medicine 17.1 (2019): 354-358.
Chicago
Zhou, Z., Tang, J., Li, W., Tao, W."Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty". Experimental and Therapeutic Medicine 17, no. 1 (2019): 354-358. https://doi.org/10.3892/etm.2018.6911
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou Z, Tang J, Li W and Tao W: Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty. Exp Ther Med 17: 354-358, 2019.
APA
Zhou, Z., Tang, J., Li, W., & Tao, W. (2019). Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty. Experimental and Therapeutic Medicine, 17, 354-358. https://doi.org/10.3892/etm.2018.6911
MLA
Zhou, Z., Tang, J., Li, W., Tao, W."Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty". Experimental and Therapeutic Medicine 17.1 (2019): 354-358.
Chicago
Zhou, Z., Tang, J., Li, W., Tao, W."Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty". Experimental and Therapeutic Medicine 17, no. 1 (2019): 354-358. https://doi.org/10.3892/etm.2018.6911
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