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Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency

  • Authors:
    • Cewen Liu
    • Hui Li
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 368-372
    |
    Published online on: November 1, 2018
       https://doi.org/10.3892/etm.2018.6916
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Abstract

Correlation of the severity of chronic kidney disease (CKD) with serum inflammation, osteoporosis and vitamin D deficiency was investigated. A total of 78 patients suffering from CKD who presented to the Union Hospital from December 2015 to December 2017 were selected randomly and divided into three groups based on the severity of the disease. Comparisons of interleukin‑6 (IL‑6), C‑reactive protein (CRP), tumor necrosis factor‑α (TNF‑α), indicators of osteoporosis [serum phosphate, serum calcium and bone mineral density (BMD)], content of 25(OH)D, serum sodium, serum potassium and BUN were conducted among groups. The correlation of in vivo creatinine (Cr) with C‑reactive protein (CRP), TNF-α, BMD and vitamin D deficiency were analyzed. With the aggravation of illness, IL‑6, CRP, TNF‑α, serum phosphate, serum sodium, serum potassium and blood urea nitrogen (BUN) were increased gradually, while serum calcium, BMD and vitamin D were decreased significantly (P<0.05). The content of Cr in patients suffering from osteoporosis was significantly higher than that in normal group (P<0.05). The Cr of patients in the group with abnormal CRP was significantly higher than that with normal CRP (P<0.05). Analysis showed that there is positive correlation between Cr and CRP (r=0.6961, P<0.001), as well as between Cr and TNF‑α (r=0.8969, P<0.001); and negative correlation between Cr and BMD (r=0.5472, P<0.001), and between Cr and 25(OH)D (r=0.4733, P<0.001). The severity of CKD is correlated with serum inflammation, osteoporosis and vitamin D deficiency. The higher the severity of the illness, the worse the condition of osteoporosis will be.
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Copy and paste a formatted citation
Spandidos Publications style
Liu C and Li H: Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency. Exp Ther Med 17: 368-372, 2019.
APA
Liu, C., & Li, H. (2019). Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency. Experimental and Therapeutic Medicine, 17, 368-372. https://doi.org/10.3892/etm.2018.6916
MLA
Liu, C., Li, H."Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency". Experimental and Therapeutic Medicine 17.1 (2019): 368-372.
Chicago
Liu, C., Li, H."Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency". Experimental and Therapeutic Medicine 17, no. 1 (2019): 368-372. https://doi.org/10.3892/etm.2018.6916
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C and Li H: Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency. Exp Ther Med 17: 368-372, 2019.
APA
Liu, C., & Li, H. (2019). Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency. Experimental and Therapeutic Medicine, 17, 368-372. https://doi.org/10.3892/etm.2018.6916
MLA
Liu, C., Li, H."Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency". Experimental and Therapeutic Medicine 17.1 (2019): 368-372.
Chicago
Liu, C., Li, H."Correlation of the severity of chronic kidney disease with serum inflammation, osteoporosis and vitamin D deficiency". Experimental and Therapeutic Medicine 17, no. 1 (2019): 368-372. https://doi.org/10.3892/etm.2018.6916
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