Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2019 Volume 17 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model

  • Authors:
    • I. A. Marino‑Martínez
    • A. G. Martínez‑Castro
    • V. M. Peña‑Martínez
    • C. A. Acosta‑Olivo
    • F. Vílchez‑Cavazos
    • A. Guzmán‑López
    • Edelmiro Pérez Rodríguez
    • V. J. Romero‑Díaz
    • J. A. Ortega‑Blanco
    • J. Lara‑Arias
  • View Affiliations / Copyright

    Affiliations: Pathology Service, Hospital Universitario ‘Dr. José E. González, Universidad Autónoma de Nuevo León, Monterrey, NL 64460, Mexico, Orthopedics and Traumatology Service, Hospital Universitario ‘Dr. José E. González, Universidad Autónoma de Nuevo León, Monterrey, NL 64460, Mexico, Obstetrics and Gynecology Service, Hospital Universitario ‘Dr. José E. González, Universidad Autónoma de Nuevo León, Monterrey, NL 64460, Mexico, Transplants Service, Hospital Universitario ‘Dr. José E. González, Universidad Autónoma de Nuevo León, Monterrey, NL 64460, Mexico, Department of Histology, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, NL 64460, Mexico, Top Health, SAPI de CV, Zapopan, JAL 45070, Mexico
    Copyright: © Marino‑Martínez et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 11-16
    |
    Published online on: November 2, 2018
       https://doi.org/10.3892/etm.2018.6924
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoarthritis (OA) is a degenerative joint disease that affects the soft tissues and bones of involved articulations as a result of deregulation between synthesis and extracellular matrix degradation in articular cartilage. The present study evaluated the effect of intra‑articular injection of human amniotic membrane (AM) as a treatment in an OA animal model in the knee. Chemical OA was developed in the knees of New Zealand rabbits. Once OA was established, the right knees only were treated with an intra‑articular injection of human AM, with the left knees considered as a negative control group. The evaluation was performed at 3 and 6 weeks post‑treatment. At 3 weeks post‑injection, the cartilage exhibited fibrillation, erosion, cracks and cell clusters in the negative control group, but not in the treated group (P=0.028). At 6 weeks post‑injection, the left knees exhibited hypertrophy, cracks, cell clusters, decreased matrix staining and structure loss. However, the right knees exhibited cell clusters without evidence of disruption in cartilage integrity (P=0.015). These results suggested that the intra‑articular injection of human AM delays histological changes of cartilage in OA.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, et al: Osteoarthritis: New insights. Part 1 The disease and its risk factors. Ann Intern Med. 133:635–646. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Giménez Basallote S, Pulido Morillo FJ and Trigueros Carrero JA: Definición, etiopatogenia, factores de riesgo y pronóstico. In: Guía de Buena Práctica Clínica en Artrosis. 2nd. International Marketing & Communication, SA (IM&C); Madrid, Spain: pp. 11–17. 2008, (In Spanish).

3 

Ajadi RA, Otesile EB and Kasali OB: Short-term changes in lipid profile following experimental osteoarthritis in dogs. Bulgarian J Veterinary Med. 15:166–171. 2012.

4 

Anitua E, Sanchez M, Nurden AT, Zalduendo MM, de la Fuente M, Azofra J and Andía I: Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatology (Oxford). 46:1769–1772. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Gajiwala K and Gajiwala AL: Evaluation of lyophilized, gamma-irradiated amnion as a biological dressing. Cell Tissue Bank. 5:73–80. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Gruss JS and Jirsch DW: Human amniotic membrane: A versatile wound dressing. Can Med Assoc J. 118:1237–1246. 1978.PubMed/NCBI

7 

Subrahmanyam M: Amniotic membrane as a cover for microskin grafts. Br J Plast Surg. 48:477–478. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Ward DJ, Bennett JP, Burgos H and Fabre J: The healing of chronic venous leg ulcers with prepared human amnion. Br J Plast Surg. 42:463–467. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Adinolfi M, Akle CA, McColl I, Fensom AH, Tansley L, Connolly P, Hsi BL, Faulk WP, Travers P and Bodmer WF: Expression of HLA antigens, beta 2-microglobulin and enzymes by human amniotic epithelial cells. Nature. 295:325–327. 1982. View Article : Google Scholar : PubMed/NCBI

10 

Akle CA, Adinolfi M, Welsh KI, Leibowitz S and McColl I: Immunogenicity of human amniotic epithelial cells after transplantation into volunteers. Lancet. 2:1003–1005. 1981. View Article : Google Scholar : PubMed/NCBI

11 

Faulk WP, Matthews R, Stevens PJ, Bennett JP, Burgos H and His BL: Human amnion as an adjunct in wound healing. Lancet. 1:1156–1158. 1980. View Article : Google Scholar : PubMed/NCBI

12 

Kim JC and Tseng SC: Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea. 14:473–484. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Zohar Y, Talmi YP, Finkelstein Y, Shvili Y, Sadov R and Laurian N: Use of human amniotic membrane in otolaryngologic practice. Laryngoscope. 97:978–980. 1987. View Article : Google Scholar : PubMed/NCBI

14 

Rennekampff HO, Dohrmann P, Föry R and Fändrich F: Evaluation of amniotic membrane as adhesion prophylaxis in a novel surgical gastroschisis model. J Invest Surg. 7:187–193. 1994. View Article : Google Scholar : PubMed/NCBI

15 

He Q, Li Q, Chen B and Wang Z: Repair of flexor tendon defects of rabbit with tissue engineering method. Chin J Traumatol. 5:200–208. 2002.PubMed/NCBI

16 

Mligiliche N, Endo K, Okamoto K, Fujimoto E and Ide C: Extracellular matrix of human amnion manufactured into tubes as conduits for peripheral nerve regeneration. J Biomed Mater Res. 63:591–600. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Parolini O, Alviano F, Bagnara GP, Bilic G, Buhring HJ, Evangelista M, Hennerbichler S, Liu B, Magatti M, Mao N, et al: Concise review: Isolation and characterization of cells from human term placenta: Outcome of the first international workshop on placenta derived stem cells. Stem Cells. 26:300–311. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Miki T, Lehmann T, Cai H, Stolz DB and Strom SC: Stem cell characteristics of amniotic epithelial cells. Stem Cells. 23:1549–1559. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Portmann Lanz CB, Schoeberlein A, Huber A, Sager R, Malek A, Holzgreve W and Surbek DV: Placental mesenchymal stem cells as potential autologous graft for pre- and perinatal neuro regeneration. Am J Obstet Gynecol. 194:664–673. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Sakuragawa N, Kakinuma K, Kikuchi A, Okano H, Uchida S, Kamo I, Kobayashi M and Yokoyama Y: Human amnion mesenchyme cells express phenotypes of neuroglial progenitor cells. J Neurosci Res. 78:208–214. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Wolbank S, Peterbauer A, Fahrner M, Hennerbichler S, van Griensven M, Stadler G, Redl H and Gabriel C: Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: A comparison with human mesenchymal stem cells from adipose tissue. Tissue Eng. 13:1173–1183. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Zhao P, Ise H, Hongo M, Ota M, Konishi I and Nikaido T: Human amniotic mesenchymal cells have some characteristics of cardiomyocytes. Transplantation. 79:528–535. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Stadler G, Hennerbichler S, Lindenmair A, Peterbauer A, Hofer K, van Griensven M, Gabriel C, Redl H and Wolbank S: Phenotypic shift of human amniotic epithelial cells in culture is associated with reduced osteogenic differentiation in vitro. Cytotherapy. 10:743–752. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Lindenmair A, Wolbank S, Stadler G, Meinl A, Peterbauer-Scherb A, Eibl J, Polin H, Gabriel C, van Griensven M and Redl H: Osteogenic differentiation of intact human amniotic membrane. Biomaterials. 31:8659–8665. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Kikuchi T, Sakuta T and Yamaguchi T: Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits. Osteoarthritis Cartilage. 6:177–186. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Yoshioka M, Coutts RD, Amiel D and Hacker SA: Characterization of a model of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage. 4:87–98. 1996. View Article : Google Scholar : PubMed/NCBI

27 

Mankin HJ, Dorfman H, Lippiello L and Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 53:523–537. 1971. View Article : Google Scholar : PubMed/NCBI

28 

Buckland J: Osteoarthritis: Blocking cartilage damage in a rat model of OA by intra-articular injection of an amniotic membrane allograft. Nat Rev Rheumatol. 10:1982014. View Article : Google Scholar : PubMed/NCBI

29 

Willett NJ, Thote T, Lin AS, Moran S, Raji Y, Sridaran S, Stevens HY and Guldberg RE: Intraarticular injection of micronized dehydrated human amnion/chorion membrane attenuates osteoarthritis development. Arthritis Res Ther. 16:R472014. View Article : Google Scholar : PubMed/NCBI

30 

Raines AL, Shih MS, Chua L, Su CW, Tseng SC and O'Connell J: Efficacy of particulate amniotic membrane and umbilical cord tissues in attenuating cartilage destruction in an osteoarthritis model. Tissue Eng Part A. 23:12–19. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Vines JB, Aliprantis AO, Gomoll AH and Farr J: Cryopreserved amniotic suspension for the treatment of knee osteoarthritis. J Knee Surg. 29:443–450. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Díaz-Prado S, Rendal-Vázquez ME, Muiños-López E, Hermida-Gómez T, Rodríguez-Cabarcos M, Fuentes-Boquete I, de Toro FJ and Blanco FJ: Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair. Cell Tissue Bank. 11:183–195. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Lucero JM, Castiglioni AE, Hovanyecz P, Gorla A, Berasategui O, Fedrigo GV and Lorenti AS: Culture of chondrocytes on an acellular matrix derived from amniochorionic membrane. Rev Asoc Argent Ortop Traumatol. 77:207–212. 2012.(In Spanish). View Article : Google Scholar

34 

Bischoff M, Stachon T, Seitz B, Huber M, Zawada M, Langenbucher A and Szentmáry N: Growth factor and interleukin concentrations in amniotic membrane-conditioned medium. Curr Eye Res. 42:174–180. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Kim YI, Ryu JS, Yeo JE, Choi YJ, Kim YS, Ko K and Koh YG: Overexpression of TGF-β1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells. Biochem Biophys Res Commun. 450:1593–1599. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Marino‑Martínez IA, Martínez‑Castro AG, Peña‑Martínez VM, Acosta‑Olivo CA, Vílchez‑Cavazos F, Guzmán‑López A, Pérez Rodríguez E, Romero‑Díaz VJ, Ortega‑Blanco JA, Lara‑Arias J, Lara‑Arias J, et al: Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model. Exp Ther Med 17: 11-16, 2019.
APA
Marino‑Martínez, I.A., Martínez‑Castro, A.G., Peña‑Martínez, V.M., Acosta‑Olivo, C.A., Vílchez‑Cavazos, F., Guzmán‑López, A. ... Lara‑Arias, J. (2019). Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model. Experimental and Therapeutic Medicine, 17, 11-16. https://doi.org/10.3892/etm.2018.6924
MLA
Marino‑Martínez, I. A., Martínez‑Castro, A. G., Peña‑Martínez, V. M., Acosta‑Olivo, C. A., Vílchez‑Cavazos, F., Guzmán‑López, A., Pérez Rodríguez, E., Romero‑Díaz, V. J., Ortega‑Blanco, J. A., Lara‑Arias, J."Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model". Experimental and Therapeutic Medicine 17.1 (2019): 11-16.
Chicago
Marino‑Martínez, I. A., Martínez‑Castro, A. G., Peña‑Martínez, V. M., Acosta‑Olivo, C. A., Vílchez‑Cavazos, F., Guzmán‑López, A., Pérez Rodríguez, E., Romero‑Díaz, V. J., Ortega‑Blanco, J. A., Lara‑Arias, J."Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model". Experimental and Therapeutic Medicine 17, no. 1 (2019): 11-16. https://doi.org/10.3892/etm.2018.6924
Copy and paste a formatted citation
x
Spandidos Publications style
Marino‑Martínez IA, Martínez‑Castro AG, Peña‑Martínez VM, Acosta‑Olivo CA, Vílchez‑Cavazos F, Guzmán‑López A, Pérez Rodríguez E, Romero‑Díaz VJ, Ortega‑Blanco JA, Lara‑Arias J, Lara‑Arias J, et al: Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model. Exp Ther Med 17: 11-16, 2019.
APA
Marino‑Martínez, I.A., Martínez‑Castro, A.G., Peña‑Martínez, V.M., Acosta‑Olivo, C.A., Vílchez‑Cavazos, F., Guzmán‑López, A. ... Lara‑Arias, J. (2019). Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model. Experimental and Therapeutic Medicine, 17, 11-16. https://doi.org/10.3892/etm.2018.6924
MLA
Marino‑Martínez, I. A., Martínez‑Castro, A. G., Peña‑Martínez, V. M., Acosta‑Olivo, C. A., Vílchez‑Cavazos, F., Guzmán‑López, A., Pérez Rodríguez, E., Romero‑Díaz, V. J., Ortega‑Blanco, J. A., Lara‑Arias, J."Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model". Experimental and Therapeutic Medicine 17.1 (2019): 11-16.
Chicago
Marino‑Martínez, I. A., Martínez‑Castro, A. G., Peña‑Martínez, V. M., Acosta‑Olivo, C. A., Vílchez‑Cavazos, F., Guzmán‑López, A., Pérez Rodríguez, E., Romero‑Díaz, V. J., Ortega‑Blanco, J. A., Lara‑Arias, J."Human amniotic membrane intra‑articular injection prevents cartilage damage in an osteoarthritis model". Experimental and Therapeutic Medicine 17, no. 1 (2019): 11-16. https://doi.org/10.3892/etm.2018.6924
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team