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Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo

  • Authors:
    • Xuesong Yang
    • Lingyi Yan
    • Da Ha
    • Lina Qu
    • Ling Liu
    • Yu Tao
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Daqing Long Nan Hospital, Daqing, Heilongjiang 163453, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 408-412
    |
    Published online on: November 7, 2018
       https://doi.org/10.3892/etm.2018.6937
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Abstract

Changes in the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and granulocyte-macrophage colony stimulating factor (GM-CSF) in the skin tissue fluid, and the expression of interleukin (IL)-6, IL-17 and tumor necrosis factor-α (TNF-α) in the blood of patients with vitiligo were investigated. One hundred and twenty patients diagnosed with vitiligo and treated in Daqing Long Nan Hospital from March 2014 to March 2016 were selected, including 88 patients with vitiligo vulgaris and 32 patients with segmental vitiligo. Comparative analyses were performed for research indexes. Another 80 healthy volunteers receiving physical examination were selected as healthy controls. The levels of GM-CSF in tissue fluid were detected via radioimmunoassay (RIA). The levels of sICAM-1 in tissue fluid and IL-6, IL-17 and TNF-α in the blood were detected via enzyme-linked immunosorbent assay (ELISA). The expression levels of IL-6, IL-17 and TNF-α in patients with progressive vitiligo were significantly higher than those in patients with stable vitiligo (P<0.05). The levels of sICAM-1 and GM-CSF in the skin tissue fluid at white spots of patients with vitiligo vulgaris were significantly higher than those in the skin tissue fluid at non-white spots (P<0.05). sICAM-1 levels had significant positive correlations with the levels of IL-6, IL-17 and TNF-α in the blood (P<0.05). The levels of sICAM-1 in the skin tissue fluid and IL-6 in the blood of patients with vitiligo were negatively correlated with the course of disease (P<0.05). The levels of sICAM-1 in the skin tissue fluid and IL-6 and IL-17 in the blood of patients with vitiligo were positively correlated with the skin lesion area of ​​patients (P<0.05). The levels of sICAM-1 and GM-CSF in the skin tissue fluid, and the expression levels of IL-6, IL-17 and TNF-α in the blood of patients with vitiligo are abnormal.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Yan L, Ha D, Qu L, Liu L and Tao Y: Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo. Exp Ther Med 17: 408-412, 2019.
APA
Yang, X., Yan, L., Ha, D., Qu, L., Liu, L., & Tao, Y. (2019). Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo. Experimental and Therapeutic Medicine, 17, 408-412. https://doi.org/10.3892/etm.2018.6937
MLA
Yang, X., Yan, L., Ha, D., Qu, L., Liu, L., Tao, Y."Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo". Experimental and Therapeutic Medicine 17.1 (2019): 408-412.
Chicago
Yang, X., Yan, L., Ha, D., Qu, L., Liu, L., Tao, Y."Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo". Experimental and Therapeutic Medicine 17, no. 1 (2019): 408-412. https://doi.org/10.3892/etm.2018.6937
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Yan L, Ha D, Qu L, Liu L and Tao Y: Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo. Exp Ther Med 17: 408-412, 2019.
APA
Yang, X., Yan, L., Ha, D., Qu, L., Liu, L., & Tao, Y. (2019). Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo. Experimental and Therapeutic Medicine, 17, 408-412. https://doi.org/10.3892/etm.2018.6937
MLA
Yang, X., Yan, L., Ha, D., Qu, L., Liu, L., Tao, Y."Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo". Experimental and Therapeutic Medicine 17.1 (2019): 408-412.
Chicago
Yang, X., Yan, L., Ha, D., Qu, L., Liu, L., Tao, Y."Changes in sICAM-1 and GM-CSF levels in skin tissue fluid and expression of IL-6, IL-17 and TNF-α in blood of patients with vitiligo". Experimental and Therapeutic Medicine 17, no. 1 (2019): 408-412. https://doi.org/10.3892/etm.2018.6937
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