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Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma

  • Authors:
    • Xiaobo Lu
    • Xuefeng Wan
    • Xiaoran Li
    • Kejun Pan
    • Wubuli Maimaitiaili
    • Yuexin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of Dermatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 27-34
    |
    Published online on: November 8, 2018
       https://doi.org/10.3892/etm.2018.6941
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Abstract

The present study investigated the expression of Toll‑like receptor 4 (TLR4) and proteins involved in its associated signaling pathways in patients with classic Kaposi's sarcoma (KS) and acquired immune deficiency syndrome (AIDS)‑associated KS (AIDS‑KS) in Xinjiang Autonomous Region of China. A total of 35 patients with KS were enrolled in the present study between May 2011 and July 2013, including 26 cases of AIDS‑KS and 9 cases of classic KS. Another 10 healthy subjects of the Uygur ethnic group were included in the normal control group. KS tissues were subjected to hematoxylin and eosin staining and immunohistochemical staining. To measure the expression of mRNA, reverse‑transcription quantitative polymerase chain reaction was performed. To determine protein expression, western blot analysis was employed. AIDS‑KS was mainly distributed in the face and limbs, while classic KS was mainly distributed in the limbs. The histopathological characteristics of AIDS‑KS and classic KS tissues were different from those of normal tissues. TLR4 was mainly distributed in the dermis of KS tissues. The mRNA expression levels of TLR4 were reduced in classic KS and AIDS‑KS. The protein expression levels of RAS, RAF, nuclear factor (NF)‑κB P65 and P50 as well as inhibitor of NF‑κB‑α of the TLR4 signaling pathway in AIDS‑KS and KS tissues were higher than those in normal tissues. In conclusion, the expression of TLR4 gene in KS tissues was decreased, while the expression of proteins of the TLR4 signaling pathway was upregulated in KS. Downregulation of TLR4 may be associated with the occurrence and development of AIDS‑KS, while its restoration may represent a novel therapeutic approach for AIDS‑KS.
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1 

Cancian L, Hansen A and Boshoff C: Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogramming. Trends Cell Biol. 23:421–432. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Wang X, Zhang Z, Liu T, Li X, Zhang Q, Wang L, Lu X, Lin R and Wen H: Analysis of infection rate of human herpes virus 8 in blood donors in Xinjiang Autonomous Region. Chin J Infect Dis. 27:502–504. 2009.(In Chinese).

3 

Lester SN and Li K: Toll-like receptors in antiviral innate immunity. J Mol Biol. 426:1246–1264. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Laresche C, Fournier E, Dupond AS, Woronoff AS, Drobacheff-Thiebaut C, Humbert P and Aubin F: Kaposi's sarcoma: A population-based cancer registry descriptive study of 57 consecutive cases diagnosed between 1977 and 2009. Int J Dermatol. 53:e549–e554. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Alcendor DJ: KSHV Down-regulates Tropoelastin in Both an in-vitro and in-vivo Kaposi's Sarcoma Model. J Oncobiomarkers. 2:1–7. 2015.PubMed/NCBI

7 

Machado PR, Farias KJ, Pereira MG, Freitas PP and Fonseca BA: Human herpesvirus 8 (HHV-8) detected by nested polymerase chain reaction (PCR) in HIV patients with or without Kaposi's sarcoma. An analytic cross-sectional study. Sao Paulo Med J. 134:187–192. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Fernandes F, Eloy C, Carimo A, Pinto P, Graves S, Simões J, Carrilho C and Lopes JM: Simultaneous presentation of Kaposi sarcoma and HHV8-associated large B-cell lymphoma in the same lymph node: A rare diagnosis in an HIV-negative patient. Am J Case Rep. 14:263–266. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Boivin G, Côté S, Cloutier N, Abed Y, Maguigad M and Routy JP: Quantification of human herpesvirus 8 by real-time PCR in blood fractions of AIDS patients with Kaposi's sarcoma and multicentric Castleman's disease. J Med Virol. 68:399–403. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Mäkinen T, Elliman S, Flanagan AM, Alitalo K and Boshoff C: Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 36:687–693. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Bauer AK, Dixon D, DeGraff LM, Cho HY, Walker CR, Malkinson AM and Kleeberger SR: Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst. 97:1778–1781. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Zhang K, Zhou B, Wang Y, Rao L and Zhang L: The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis. Eur J Cancer. 49:946–954. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Medzhitov R, Preston-Hurlburt P and Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394–397. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Li D, Yang L, Tan XH, Li F, Qin J, Guo S, Pu X and Xie J: Detection of HHV-8 DNA in Serum of 29 Xinjiang Classic Kaposi Sarcoma by Nested PCR. Chin J Dermatovenereol. 19:329–220. 2005.(In Chinese).

15 

Lagos D, Vart RJ, Gratrix F, Westrop SJ, Emuss V, Wong PP, Robey R, Imami N, Bower M, Gotch F and Boshoff C: Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus. Cell Host Microbe. 4:470–483. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Zhou L, Shang H, Wang Y, Li G, Ding H, Zhang X, Dai D and Shi W: The expression of TLR4 on peripheral blood monocyte and TNF-α concentration of plasma in Chinese HIV/AIDS patients. Chin J Microbiol Immunol. 27:1016–1019. 2007.(In Chinese).

17 

Lester RT, Yao XD, Ball TB, McKinnon LR, Kaul R, Wachihi C, Jaoko W, Plummer FA and Rosenthal KL: Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection. AIDS. 22:685–694. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Bosinger SE, Hosiawa KA, Cameron MJ, Persad D, Ran L, Xu L, Boulassel MR, Parenteau M, Fournier J, Rud EW and Kelvin DJ: Gene expression profiling of host response in models of acute HIV infection. J Immunol. 173:6858–6863. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Speicher DJ, Sehu MM, Johnson NW and Shaw DR: Successful treatment of an HIV-positive patient with unmasking Kaposi's sarcoma immune reconstitution inflammatory syndrome. J Clin Virol. 57:282–285. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Tamburro KM, Yang D, Poisson J, Fedoriw Y, Roy D, Lucas A, Sin SH, Malouf N, Moylan V, Damania B, et al: Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A. Virology. 433:220–225. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Maimaitiaili W, Pan K, Lu X, Sun X, Yibaguli A, Yang K, Zuohela T, Adili K and Zhang Y: Clinical, pathological and prognosis analyses of AIDS patients with Kaposi sarcoma. Chin J Infect Dis. 30:368–370. 2012.(In Chinese).

22 

Rea K, Sensi M, Anichini A, Canevari S and Tomassetti A: EGFR/MEK/ERK/CDK5-dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor cells. Cell Death Dis. 4:e8152013. View Article : Google Scholar : PubMed/NCBI

23 

Buscà R, Christen R, Lovern M, Clifford AM, Yue JX, Goss GG, Pouysségur J and Lenormand P: ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1. BMC Evol Biol. 15:1792015. View Article : Google Scholar : PubMed/NCBI

24 

Singh A, Ruan Y, Tippett T and Narendran A: Targeted inhibition of MEK1 by cobimetinib leads to differentiation and apoptosis in neuroblastoma cells. J Exp Clin Cancer Res. 34:1042015. View Article : Google Scholar : PubMed/NCBI

25 

Tamminen JA, Yin M, Rönty M, Sutinen E, Pasternack A, Ritvos O, Myllärniemi M and Koli K: Overexpression of activin-A and -B in malignant mesothelioma-attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. Exp Cell Res. 332:102–115. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Park HS, You GE, Yang KH, Kim JY, An S, Song JY, Lee SJ, Lim YK and Nam SY: Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells. Eur J Cell Biol. 9:653–660. 2015. View Article : Google Scholar

27 

Nguyen MP, Lee D, Lee SH, Lee HE, Lee HY and Lee YM: Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion. Oncotarget. 6:16588–16600. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Shostak K and Chariot A: EGFR and NF-κB: Partners in cancer. Trends Mol Med. 21:385–393. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Cannon M, Philpott NJ and Cesarman E: The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. J Virol. 77:57–67. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Pati S, Cavrois M, Guo HG, Foulke JS Jr, Kim J, Feldman RA and Reitz M: Activation of NF-kappaB by the human herpesvirus 8 chemokine receptor ORF74: evidence for a paracrine model of Kaposi's sarcoma pathogenesis. J Virol. 75:8660–8673. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Gregory SM, West JA, Dillon PJ, Hilscher C, Dittmer DP and Damania B: Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci USA. 106:11725–11730. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Hävemeier A, Gramolelli S, Pietrek M, Jochmann R, Stürzl M and Schulz TF: Activation of NF-κB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-κB -inducing kinase, IκB kinases, and phosphorylation of p65. J Virol. 88:13161–13172. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Jacobs SR, Gregory SM, West JA, Wollish AC, Bennett CL, Blackbourn DJ, Heise MT and Damania B: The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. J Virol. 87:798–806. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Meyer F, Ehlers E, Steadman A, Waterbury T, Cao M and Zhang L: TLR-TRIF pathway enhances the expression of KSHV replication and transcription activator. J Biol Chem. 288:20435–20442. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Ahmad H, Gubbels R, Ehlers E, Meyer F, Waterbury T, Lin R and Zhang L: Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF). J Biol Chem. 286:7865–7872. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Guo Y, Li Y, Wei X, Feng Z and Yang S: Expression of TLR2 and TLR4 in primary liver cancer. Chin J Pathophysiol. 24:1912–1915. 2008.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Lu X, Wan X, Li X, Pan K, Maimaitiaili W and Zhang Y: Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma. Exp Ther Med 17: 27-34, 2019.
APA
Lu, X., Wan, X., Li, X., Pan, K., Maimaitiaili, W., & Zhang, Y. (2019). Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma. Experimental and Therapeutic Medicine, 17, 27-34. https://doi.org/10.3892/etm.2018.6941
MLA
Lu, X., Wan, X., Li, X., Pan, K., Maimaitiaili, W., Zhang, Y."Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma". Experimental and Therapeutic Medicine 17.1 (2019): 27-34.
Chicago
Lu, X., Wan, X., Li, X., Pan, K., Maimaitiaili, W., Zhang, Y."Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma". Experimental and Therapeutic Medicine 17, no. 1 (2019): 27-34. https://doi.org/10.3892/etm.2018.6941
Copy and paste a formatted citation
x
Spandidos Publications style
Lu X, Wan X, Li X, Pan K, Maimaitiaili W and Zhang Y: Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma. Exp Ther Med 17: 27-34, 2019.
APA
Lu, X., Wan, X., Li, X., Pan, K., Maimaitiaili, W., & Zhang, Y. (2019). Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma. Experimental and Therapeutic Medicine, 17, 27-34. https://doi.org/10.3892/etm.2018.6941
MLA
Lu, X., Wan, X., Li, X., Pan, K., Maimaitiaili, W., Zhang, Y."Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma". Experimental and Therapeutic Medicine 17.1 (2019): 27-34.
Chicago
Lu, X., Wan, X., Li, X., Pan, K., Maimaitiaili, W., Zhang, Y."Expression of TLR4 gene is downregulated in acquired immune deficiency syndrome‑associated Kaposi's sarcoma". Experimental and Therapeutic Medicine 17, no. 1 (2019): 27-34. https://doi.org/10.3892/etm.2018.6941
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