Correlation analysis between 25-hydroxyvitamin D3, vitamin B12 and vitamin C and endothelial function of patients with CHD

Qin,Xiaoming; Qin,Lei; Luo,Jiachen; Liu,Baoxin; Zhao,Jinlong; Li,Hongqiang; Wei,Yidong

doi:10.3892/etm.2018.6944

January-2019 Volume 17 Issue 1

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January-2019 Volume 17 Issue 1

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Correlation analysis between 25-hydroxyvitamin D3, vitamin B12 and vitamin C and endothelial function of patients with CHD

Authors:
- Xiaoming Qin
- Lei Qin
- Jiachen Luo
- Baoxin Liu
- Jinlong Zhao
- Hongqiang Li
- Yidong Wei
View Affiliations / Copyright

Affiliations: Department of Cardiology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, Shanghai 200072, P.R. China, Department of Cardiology, Kaifeng Central Hospital, Kaifeng, Henan 475000, P.R. China

Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 418-422
|
Published online on: November 8, 2018

https://doi.org/10.3892/etm.2018.6944
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Abstract

The aim of the study was to investigate the correlation between levels of 25-hydroxyvitamin D3, vitamin B12 and C and endothelial function of patients with coronary heart disease (CHD). Forty patients with CHD diagnosed in Shanghai Tenth People's Hospital from May 2016 to April 2017 were selected as the observation group. A total of 45 healthy individuals were selected as the control group. The participants included 54 males and 31 females. General information was collected. Peripheral serum biochemical indicators, levels of 25-hydroxyvitamin D3, vitamin B12 and C, homocysteine (Hcy), nitric oxide (NO) and endothelial NOS (eNOS) were measured. Arterial lesions detected by coronary angiography were recorded and indexes of observation and control group were compared for the correlation analysis. A proportion of hypertensive patients and their body mass index (BMI) were significantly higher in the observation than in the control group (P<0.05). Levels of 25-hydroxyvitamin D3, vitamin B12 and C in peripheral blood of observation were significantly lower than those of the control group (P<0.05). Compared with the control group, incidence of single-branch lesion and non-lesion rate were significantly lower, but incidence of double- and triple-branch lesions were significantly higher in observation than in control group (P<0.05). In addition, the level of Hcy in the observation group was higher than that in the control group, but levels of NO and eNOS in observation were significantly lower than those in control group (P<0.05. The correlation analysis revealed that 25-hydroxyvitamin D3 (r=0.792, P<0.01), vitamin B12 (r=0.635, P<0.01) and vitamin C (r=0.703, P<0.01) were negatively correlated with serum NO level. Thus, hypertension, BMI, 25-hydroxyvitamin D3, vitamin B12 and C have independent predictive value for coronary endothelial dysfunction (P<0.05). In conclusion, serum levels of 25-hydroxyvitamin D3, vitamin B12 and C are closely related to vascular endothelial dysfunction in patients with CHD and affect the severity of vascular endothelial dysfunction in patients with CHD.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation analysis between 25-hydroxyvitamin D3, vitamin B12 and vitamin C and endothelial function of patients with CHD

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