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Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas

  • Authors:
    • Ying Feng
    • Ming Ni
    • Yong‑Gang Wang
    • Li‑Yong Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 51-56
    |
    Published online on: November 12, 2018
       https://doi.org/10.3892/etm.2018.6953
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Abstract

Craniopharyngiomas (CPs) are rare epithelial tumors mainly located in the sellar/parasellar region. They may be classified into two major histological subtypes, which exhibit clinical and pathological differences: Adamantinomatous CP (ACP) and papillary CP (PCP). The aim of the present study was to compare the neuroendocrine dysfunction between ACP and PCP prior to and after surgical resection. According to their pathological classification, the patients were assigned to the ACP group or the PCP group. The neuroendocrine dysfunction in these two CP subtypes was evaluated using a scoring method prior to and after surgery. A total of 741 patients with CPs were included in the present study, of which 622 were ACP and 119 were PCP. The scores on the tumor mass effect, hypothalamic dysfunction and pituitary‑target gland axis dysfunction, as well as the incidence of central diabetes insipidus in the PCP group were all significantly higher than those in the ACP group, regardless of whether the surgery had been performed or not (all P<0.05). After surgery, the scores on the tumor mass effect were significantly decreased in the ACP and PCP patients (all P<0.05), while the scores on hypothalamic dysfunction and pituitary‑target gland axis dysfunction, as well as the incidence of central diabetes insipidus were all significantly increased in ACP and PCP patients (all P<0.05). Prior to and after surgery, the PCP variant exhibited a greater damage to the neuroendocrine function compared with the ACP variant.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Ni M, Wang YG and Zhong LY: Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas. Exp Ther Med 17: 51-56, 2019.
APA
Feng, Y., Ni, M., Wang, Y., & Zhong, L. (2019). Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas. Experimental and Therapeutic Medicine, 17, 51-56. https://doi.org/10.3892/etm.2018.6953
MLA
Feng, Y., Ni, M., Wang, Y., Zhong, L."Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas". Experimental and Therapeutic Medicine 17.1 (2019): 51-56.
Chicago
Feng, Y., Ni, M., Wang, Y., Zhong, L."Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas". Experimental and Therapeutic Medicine 17, no. 1 (2019): 51-56. https://doi.org/10.3892/etm.2018.6953
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Ni M, Wang YG and Zhong LY: Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas. Exp Ther Med 17: 51-56, 2019.
APA
Feng, Y., Ni, M., Wang, Y., & Zhong, L. (2019). Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas. Experimental and Therapeutic Medicine, 17, 51-56. https://doi.org/10.3892/etm.2018.6953
MLA
Feng, Y., Ni, M., Wang, Y., Zhong, L."Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas". Experimental and Therapeutic Medicine 17.1 (2019): 51-56.
Chicago
Feng, Y., Ni, M., Wang, Y., Zhong, L."Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas". Experimental and Therapeutic Medicine 17, no. 1 (2019): 51-56. https://doi.org/10.3892/etm.2018.6953
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