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Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2

  • Authors:
    • Guohua Hao
    • Wei Duan
    • Jianping Sun
    • Jingyao Liu
    • Bo Peng
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology Ⅱ, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China
    Copyright: © Hao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 812-816
    |
    Published online on: November 15, 2018
       https://doi.org/10.3892/etm.2018.6972
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Abstract

Effects of febuxostat on serum cytokines interleukin (IL)‑1, IL‑4, IL‑6, IL‑8, tumor necrosis factor‑α (TNF‑α) and cyclooxygenase‑2 (COX‑2) in patients with gout were investigated. A total of 80 patients with gout admitted and treated in the Affiliated Zhongshan Hospital of Dalian University from January 2015 to September 2017 were selected and divided into two groups by virtue of a random number table, with 40 patients in each group. All the enrolled patients received strict gout diet adjustment and took colchicine at the same time. Patients in the control group were additionally treated with allopurinol, while those in the the observation group were administered with febuxostat. The serum uric acid levels were compared between the two groups. The number of gout attacks and adverse reactions were recorded, and the variations in COX‑2 positive value integral were clarified. At different time‑points of observation, the serum uric acid levels in the observation group were significantly lower than those in the control group (p<0.05). Moreover, at 3 months after treatment, the levels of inflammatory cytokines in the serum in the observation group were decreased compared with those in the control group (p<0.05). The IL‑1 and TNF‑α levels were lower in the observation group at 1 week, 1 and 3 months after treatment compared with those in the control group (p<0.05). Furthermore, it was discovered that at 3 months after treatment, the COX‑2 positive value integral in the observation group was superior to that in the control group (p<0.05). During follow‑up, the number of gout attacks that needed medical intervention in the observation group was smaller than that in the control group (p<0.05). Compared with allopurinol therapy, febuxostat therapy can remarkably inhibit inflammatory responses in the body, relieve clinical symptoms and reduce relapse of the patients with gout.
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1 

Richette P, Latourte A and Bardin T: Cardiac and renal protective effects of urate-lowering therapy. Rheumatology (Oxford). 57 suppl_1:i47–i50. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Foody J, Turpin RS, Tidwell BA, Lawrence D and Schulman KL: Major cardiovascular events in patients with gout and associated cardiovascular disease or heart failure and chronic kidney disease initiating a xanthine oxidase inhibitor. Am Health Drug Benefits. 10:393–401. 2017.PubMed/NCBI

3 

Kim Y, Oh HC, Park JW, Kim IS, Kim JY, Kim KC, Chae DS, Jo WL and Song JH: Diagnosis and treatment of inflammatory joint disease. Hip Pelvis. 29:211–222. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Anandh U and Jayanna K: Nontubercular mycobacterial infection in a renal allograft recipient. Indian J Nephrol. 27:478–481. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Beslon V, Moreau P, Maruani A, Maisonneuve H, Giraudeau B and Fournier JP: Effects of discontinuation of urate-lowering therapy: A systematic review. J Gen Intern Med. 33:358–366. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Ruiz Perez F, Sanchez-Piedra CA, Sanchez-Costa JT, Andres M, Diaz-Torne C, Jimenez-Palop M, De Miguel E, Moragues C and Sivera F: Improvement in diagnosis and treat-to-target management of hyperuricemia in gout: Results from the GEMA-2 transversal study on practice. Rheumatol Ther. 5:243–253. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Jones G, Panova E and Day R: Guideline development for the management of gout: Role of combination therapy with a focus on lesinurad. Drug Des Devel Ther. 11:3077–3081. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yamanaka H, Tamaki S, Ide Y, Kim H, Inoue K, Sugimoto M, Hidaka Y, Taniguchi A, Fujimori S and Yamamoto T: Stepwise dose increase of febuxostat is comparable with colchicine prophylaxis for the prevention of gout flares during the initial phase of urate-lowering therapy: Results from FORTUNE-1, a prospective, multicentre randomised study. Ann Rheum Dis. 77:270–276. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Zhou C, Xue C, Yang B, Wang W, Xu Y, Huang F and Wang Y: Amputation of the first metatarsophalangeal joint due to a giant gouty tophi: A case report. Medicine (Baltimore). 96:e84412017. View Article : Google Scholar : PubMed/NCBI

10 

Sheer R, Null KD, Szymanski KA, Sudharshan L, Banovic J and Pasquale MK: Predictors of reaching a serum uric acid goal in patients with gout and treated with febuxostat. Clinicoecon Outcomes Res. 9:629–639. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Collison J: Crystal arthritis: Febuxostat reduces synovitis in early gout. Nat Rev Rheumatol. 13:6942017. View Article : Google Scholar

12 

Cutolo M, Cimmino MA and Perez-Ruiz F: Potency on lowering serum uric acid in gout patients: A pooled analysis of registrative studies comparing febuxostat vs. allopurinol. Eur Rev Med Pharmacol Sci. 21:4186–4195. 2017.PubMed/NCBI

13 

Huneycutt E, Board C and Clements JN: Lesinurad, a selective URAT-1 inhibitor with a novel mechanism in combination with a xanthine oxidase inhibitor, for hyperuricemia associated with gout. J Pharm Pract. Jan 1–2017.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

14 

Sanchez-Niño MD, Zheng-Lin B, Valiño-Rivas L, Sanz AB, Ramos AM, Luño J, Goicoechea M and Ortiz A: Lesinurad: What the nephrologist should know. Clin Kidney J. 10:679–687. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Dalbeth N, Saag KG, Palmer WE, Choi HK, Hunt B, MacDonald PA, Thienel U and Gunawardhana L: Effects of febuxostat in early gout: A randomized, double-blind, placebo-controlled study. Arthritis Rheumatol. 69:2386–2395. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Davies K and Bukhari MAS: Recent pharmacological advances in the management of gout. Rheumatology (Oxford). 2017:1093–1096. 2017.

17 

Plumpton CO, Alfirevic A, Pirmohamed M and Hughes DA: Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford). 56:1729–1739. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Britnell SR, Chillari KA and Brown JN: The role of xanthine oxidase inhibitors in patients with history of stroke: A systematic review. Curr Vasc Pharmacol. 2017:128–135. 2017.

19 

Kim S, Kim HJ, Ahn HS, Oh SW, Han KH, Um TH, Cho CR and Han SY: Renoprotective effects of febuxostat compared with allopurinol in patients with hyperuricemia: A systematic review and meta-analysis. Kidney Res Clin Pract. 36:274–281. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Hill-McManus D, Soto E, Marshall S, Lane S and Hughes D: Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout. Br J Clin Pharmacol. 84:142–152. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hao G, Duan W, Sun J, Liu J and Peng B: Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2. Exp Ther Med 17: 812-816, 2019.
APA
Hao, G., Duan, W., Sun, J., Liu, J., & Peng, B. (2019). Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2. Experimental and Therapeutic Medicine, 17, 812-816. https://doi.org/10.3892/etm.2018.6972
MLA
Hao, G., Duan, W., Sun, J., Liu, J., Peng, B."Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2". Experimental and Therapeutic Medicine 17.1 (2019): 812-816.
Chicago
Hao, G., Duan, W., Sun, J., Liu, J., Peng, B."Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2". Experimental and Therapeutic Medicine 17, no. 1 (2019): 812-816. https://doi.org/10.3892/etm.2018.6972
Copy and paste a formatted citation
x
Spandidos Publications style
Hao G, Duan W, Sun J, Liu J and Peng B: Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2. Exp Ther Med 17: 812-816, 2019.
APA
Hao, G., Duan, W., Sun, J., Liu, J., & Peng, B. (2019). Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2. Experimental and Therapeutic Medicine, 17, 812-816. https://doi.org/10.3892/etm.2018.6972
MLA
Hao, G., Duan, W., Sun, J., Liu, J., Peng, B."Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2". Experimental and Therapeutic Medicine 17.1 (2019): 812-816.
Chicago
Hao, G., Duan, W., Sun, J., Liu, J., Peng, B."Effects of febuxostat on serum cytokines IL‑1, IL‑4, IL‑6, IL‑8, TNF‑α and COX‑2". Experimental and Therapeutic Medicine 17, no. 1 (2019): 812-816. https://doi.org/10.3892/etm.2018.6972
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