Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2019 Volume 17 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Isolated angioedema: An overview of clinical features and etiology (Review)

  • Authors:
    • Irena Nedelea
    • Diana Deleanu
  • View Affiliations / Copyright

    Affiliations: Allergology and Immunology Discipline, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
  • Pages: 1068-1072
    |
    Published online on: November 16, 2018
       https://doi.org/10.3892/etm.2018.6982
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angioedema can occur in isolation, accompanied by urticaria, or as a feature of anaphylaxis in mast cell-mediated disorders, bradykinin-mediated disorders, as well as in others with unknown mechanisms, such as infections, rare disorders, or idiopathic angioedema. In mast cell-mediated angioedema, other signs and symptoms of mast cell-mediator release are frequently seen. However, clear evidence of mast cell degranulation may be absent in histaminergic angioedema. Bradykinin-induced angioedema is not associated with urticaria or other symptoms of type I hypersensitivity reactions. For many of the known triggers of angioedema, the mechanism is unclear. While mast cell and bradykinin-mediated angioedema are relatively well defined in terms of diagnostic and therapeutic approach, angioedema with unknown mechanisms represents a challenge for patients and clinicians alike. Elucidating the clinical pattern and the possible causes of isolated angioedema is the key to a correct diagnosis. This review summarizes the causes, and clinical features of angioedema, with a focus on isolated angioedema.
View Figures
View References

1 

Quincke H: Acute localized edema of the skin. Monatschr Prakt Dermatol. 1:129–131. 1882.

2 

Osler W: Landmark publication from The American Journal of the Medical Sciences: Hereditary angio-neurotic oedema. 1888. Am J Med Sci. 339:175–178. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Craig TJ, Bernstein JA, Farkas H, Bouillet L and Boccon-Gibod I: Diagnosis and treatment of bradykinin-mediated angioedema: Outcomes from an angioedema expert consensus meeting. Int Arch Allergy Immunol. 165:119–127. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Boccon-Gibod I and Bouillet L: Angioedema and urticaria. Ann Dermatol Venereol. 141 (Suppl 3):S586–S595. 2014.(In French). View Article : Google Scholar : PubMed/NCBI

5 

Lenschow M, Bas M, Johnson F, Wirth M and Strassen U: A score for the differential diagnosis of bradykinin- and histamine-induced head and neck swellings. Eur Arch Otorhinolaryngol. 275:1767–1773. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Rosen FS, Pensky J, Donaldson V and Charache P: Hereditary angioneurotic edema: Two genetic variants. Science. 148:957–958. 1965. View Article : Google Scholar : PubMed/NCBI

7 

Davis AE III: C1 inhibitor and hereditary angioneurotic edema. Annu Rev Immunol. 6:595–628. 1988. View Article : Google Scholar : PubMed/NCBI

8 

Zuraw B and Christiansen S: Hereditary angioedema and bradykinin-mediated angioedema. Middeleton's Allergy Principles and Practice. 1. 8th. Elsevier; Philadelphia, PA: pp. 588–601. 2014

9 

Bork K, Barnstedt SE, Koch P and Traupe H: Hereditary angioedema with normal C1-inhibitor activity in women. Lancet. 356:213–217. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Frank MM, Gelfand JA and Atkinson JP: Hereditary angioedema: The clinical syndrome and its management. Ann Intern Med. 84:580–593. 1976. View Article : Google Scholar : PubMed/NCBI

11 

Bork K, Meng G, Staubach P and Hardt J: Hereditary angioedema: New findings concerning symptoms, affected organs, and course. Am J Med. 119:267–274. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Agostoni A and Cicardi M: Hereditary and acquired C1-inhibitor deficiency: Biological and clinical characteristics in 235 patients. Medicine (Baltimore). 71:206–215. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Molina C, Brun J, Coulet M, Betail G, Wahl D and Hartmann L: Diagnostic and therapeutic problems associated with hereditary deficiency of the C1 esterase inhibitor. Clin Allergy. 7:127–135. 1977. View Article : Google Scholar : PubMed/NCBI

14 

Caballero T, Maurer M, Longhurst HJ, Aberer W, Bouillet L and Fabien V: IOS Study Group: Triggers and prodromal symptoms of angioedema attacks in patients with hereditary angioedema. J Investig Allergol Clin Immunol. 26:383–386. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Castelli R, Wu MA, Arquati M, Zanichelli A, Suffritti C, Rossi D and Cicardi M: High prevalence of splenic marginal zone lymphoma among patients with acquired C1 inhibitor deficiency. Br J Haematol. 172:902–908. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Slater EE, Merrill DD, Guess HA, Roylance PJ, Cooper WD, Inman WH and Ewan PW: Clinical profile of angioedema associated with angiotensin converting-enzyme inhibition. JAMA. 260:967–970. 1988. View Article : Google Scholar : PubMed/NCBI

17 

Sabroe RA and Black AK: Angiotensin-converting enzyme (ACE) inhibitors and angio-oedema. Br J Dermatol. 136:153–158. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Campo P, Fernandez TD, Canto G and Mayorga C: Angioedema induced by angiotensin-converting enzyme inhibitors. Curr Opin Allergy Clin Immunol. 13:337–344. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Leiferman KM: Hypereosinophilic syndrome. Semin Dermatol. 14:122–128. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Emonet S, Kaya G and Hauser C: Gleich's syndrome. Ann Dermatol Venereol. 127:616–618. 2000.(In French). PubMed/NCBI

21 

Zenone T, Felman P, Malcus C, Durieu I and Durand DV: Indolent course of a patient with hypereosinophilic syndrome associated with clonal T-cell proliferation. Am J Med. 107:509–511. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Geha RS, Quinti I, Austen KF, Cicardi M, Sheffer A and Rosen FS: Acquired C1-inhibitor deficiency associated with antiidiotypic antibody to monoclonal immunoglobulins. N Engl J Med. 312:534–540. 1985. View Article : Google Scholar : PubMed/NCBI

23 

Jung M and Rice L: ‘Surgical’ abdomen in a patient with chronic lymphocytic leukemia: A case of acquired angioedema. J Gastrointest Surg. 15:2262–2266. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Nilsen A and Matre R: Acquired angioedema and hypocompleentemia in a patient with myelofibrosis. Effect of danazol treatment. Acta Med Scand. 207:123–125. 1980. View Article : Google Scholar : PubMed/NCBI

25 

Khanfar A, Trikha A, Bonds R and Jana B: Angioedema with normal C1q and C1 inhibitor: An atypical presentation of Waldenström macroglobulinemia. Int J Hematol. 97:654–656. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Casali P, Borzini P, Pioltelli P, Invernizzi F and Zanussi C: Acquired C1-inhibitor deficiency in essential cryoglobulinemia and macrocryoglobulinemia. Acta Haematol. 59:277–284. 1978. View Article : Google Scholar : PubMed/NCBI

27 

Hochstadter EF and Ben-Shoshan M: Cold-induced urticaria: Challenges in diagnosis and management. BMJ Case Rep. 2013.bcr2013010441, 2013. doi: 10.1136/bcr-2013-010441. View Article : Google Scholar : PubMed/NCBI

28 

Jones JM, Reich KA and Raval DG: Angioedema in a 47-year-old woman with hypocomplementemic urticarial vasculitis syndrome. J Am Osteopath Assoc. 112:90–92. 2012.PubMed/NCBI

29 

Maejima H and Katsuoka K: A case of nonepisodic angioedema with eosinophilia associated with livedo reticularis and erythema before onset of edema of the legs. Cutis. 93:33–37. 2014.PubMed/NCBI

30 

Habibagahi Z, Ruzbeh J, Yarmohammadi V, Kamali M and Rastegar MH: Refractory angioedema in a patient with systemic lupus erythematosus. Iran J Med Sci. 40:372–375. 2015.PubMed/NCBI

31 

Bertinotti L, Miniati I and Cerinic MM: Angioedema and systemic sclerosis. A review of the literature. Scand J Rheumatol. 31:178–180. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Cohen SH, Koethe SM, Kozin F, Rodey G, Arkins JA and Fink JN: Acquired angioedema associated with rectal carcinoma and its response to danazol therapy. Acquired angioedema treated with danazol. J Allergy Clin Immunol. 62:217–221. 1978. View Article : Google Scholar : PubMed/NCBI

33 

Wu MA and Castelli R: The Janus faces of acquired angioedema: C1-inhibitor deficiency, lymphoproliferation and autoimmunity. Clin Chem Lab Med. 54:207–214. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Varvarovska J, Sykora J, Stozicky F and Chytra I: Acquired angioedema and Helicobacter pylori infection in a child. Eur J Pediatr. 162:707–709. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Cicardi M, Frangi D, Bergamaschini L, Gardinali M, Sacchi G and Agostoni A: Acquired C1 inhibitor deficiency with angioedema symptoms in a patient infected with Echinococcus granulosus. Complement. 2:133–139. 1985. View Article : Google Scholar : PubMed/NCBI

36 

Gabb GM, Ryan P, Wing LM and Hutchinson KA: Epidemiological study of angioedema and ACE inhibitors. Aust N Z J Med. 26:777–782. 1996. View Article : Google Scholar : PubMed/NCBI

37 

Constantin MM: Value and impact of patch testing in patients with allergic contact dermatitis. Rom J Lab Med. 20:287–292. 2012.

38 

Koley S, Mandal RK, Das G, Roy AC and Banerjee S: Unilateral blepharochalasis of right eye. Indian J Dermatol. 59:525–526. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Roveda JM: Romaña's sign. Cole's unilateral trypanosomiasic ophthalmia. Arch Oftalmol B Aires. 42:1–4. 1967.(In Spanish).

40 

Herrmann A and Stange T: Facial swelling caused by small cell lung cancer: A rare differential diagnosis of angioedema. HNO. 59:188–191. 2011.(In German). View Article : Google Scholar : PubMed/NCBI

41 

Kakimoto C, Sparks C and White AA: Melkersson-Rosenthal syndrome: A form of pseudoangioedema. Ann Allergy Asthma Immunol. 99:185–189. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nedelea I and Deleanu D: Isolated angioedema: An overview of clinical features and etiology (Review). Exp Ther Med 17: 1068-1072, 2019.
APA
Nedelea, I., & Deleanu, D. (2019). Isolated angioedema: An overview of clinical features and etiology (Review). Experimental and Therapeutic Medicine, 17, 1068-1072. https://doi.org/10.3892/etm.2018.6982
MLA
Nedelea, I., Deleanu, D."Isolated angioedema: An overview of clinical features and etiology (Review)". Experimental and Therapeutic Medicine 17.2 (2019): 1068-1072.
Chicago
Nedelea, I., Deleanu, D."Isolated angioedema: An overview of clinical features and etiology (Review)". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1068-1072. https://doi.org/10.3892/etm.2018.6982
Copy and paste a formatted citation
x
Spandidos Publications style
Nedelea I and Deleanu D: Isolated angioedema: An overview of clinical features and etiology (Review). Exp Ther Med 17: 1068-1072, 2019.
APA
Nedelea, I., & Deleanu, D. (2019). Isolated angioedema: An overview of clinical features and etiology (Review). Experimental and Therapeutic Medicine, 17, 1068-1072. https://doi.org/10.3892/etm.2018.6982
MLA
Nedelea, I., Deleanu, D."Isolated angioedema: An overview of clinical features and etiology (Review)". Experimental and Therapeutic Medicine 17.2 (2019): 1068-1072.
Chicago
Nedelea, I., Deleanu, D."Isolated angioedema: An overview of clinical features and etiology (Review)". Experimental and Therapeutic Medicine 17, no. 2 (2019): 1068-1072. https://doi.org/10.3892/etm.2018.6982
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team