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Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures

  • Authors:
    • Guohao Liu
    • Guiwen Lyu
    • Na Yang
    • Boyu Chen
    • Jian Yang
    • Yiwen Hu
    • Yi Lei
    • Jun Xia
    • Fan Lin
    • Guoguang Fan
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Radiology, The Second People's Hospital of Shenzhen, Shenzhen, Guangdong 518035, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 603-612
    |
    Published online on: November 27, 2018
       https://doi.org/10.3892/etm.2018.7018
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Abstract

Neuroimaging techniques have been used to investigate idiopathic generalized epilepsy with generalized tonic‑clonic seizures (IGE‑GTCS) and different studies employing these methods have produced varying results. However, there have been few studies exploring diffusional kurtosis imaging (DKI) and regional homogeneity (ReHo) techniques in patients with IGE‑GTCS. In the current study, resting‑state functional magnetic resonance imaging (fMRI) and DKI data were collected from 28 patients with IGE‑GTCS and 28 healthy controls. The ReHo method and tract‑based spatial statistical (TBSS) analysis were performed to compare differences between the groups. Compared with healthy controls, patients with IGE‑GTCS exhibited markedly increased ReHo in the bilateral putamen, the thalamus, right pallidum, right supplementary motor area and the bilateral paracentral lobules. Compared with healthy controls, patients with IGE‑GTCS also exhibited markedly decreased ReHo in the posterior cingulate/precuneus, left angular gyrus and dorsolateral prefrontal cortex. In patients with IGE‑GTCS, DKI revealed lower fractional anisotropy in the left anterior/superior corona radiata, left superior longitudinal fasciculus and genu/body of the corpus callosum. Higher mean diffusivity was detected in the bilateral anterior corona radiata, left superior corona radiata, left cingulum, and genu/body/splenium of the corpus callosum. Furthermore, reduced mean kurtosis values were identified over the bilateral superior/posterior corona radiate, left anterior corona radiata, right superior longitudinal fasciculus, left posterior thalamic radiation and the genu/body/splenium of the corpus callosum. Therefore, the results of the current study revealed abnormalities in spontaneous activity in the gray and white matter tracts in patients with IGE‑GTCS. These results suggest that novel MRI technology may be useful to help determine the pathogenesis of IGE‑GTCS.
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View References

1 

Ferrie CD: Idiopathic generalized epilepsies imitating focal epilepsies. Epilepsia. 46 Suppl 9:S91–S95. 2005. View Article : Google Scholar

2 

Szaflarski JP, Kay B, Gotman J, Privitera MD and Holland SK: The relationship between the localization of the generalized spike and wave discharge generators and the response to valproate. Epilepsia. 54:471–480. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Zang Y, Jiang T, Lu Y, He Y and Tian L: Regional homogeneity approach to fMRI data analysis. NeuroImage. 22:394–400. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Jiang S, Luo C, Liu Z, Hou C, Wang P, Dong L, Zhong C, Lai Y, Xia Y and Yao D: Altered local spontaneous brain activity in juvenile myoclonic epilepsy: A preliminary resting-state fMRI study. Neural Plast. 2016:35472032016. View Article : Google Scholar : PubMed/NCBI

5 

Zeng H, Pizarro R, Nair VA, La C and Prabhakaran V: Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy. Epilepsia. 54:658–666. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Yang T, Fang Z, Ren J, Xiao F, Li Q, Liu L, Lei D, Gong Q and Zhou D: Altered spontaneous activity in treatment-naive childhood absence epilepsy revealed by regional homogeneity. J Neurol Sci. 340:58–62. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Iwabuchi SJ and Palaniyappan L: Abnormalities in the effective connectivity of visuothalamic circuitry in schizophrenia. Psychol Med. 47:1300–1310. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yuan X, Han Y, Wei Y, Xia M, Sheng C, Jia J and He Y: Regional homogeneity changes in amnestic mild cognitive impairment patients. Neurosci Lett. 629:1–8. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Ji GJ, Zhang Z, Xu Q, Zang YF, Liao W and Lu G: Generalized tonic-clonic seizures: Aberrant interhemispheric functional and anatomical connectivity. Radiology. 271:839–847. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Y, Gao Y, Zhou M, Wu J, Zee C and Wang D: A diffusional kurtosis imaging study of idiopathic generalized epilepsy with unilateral interictal epileptiform discharges in children. J Neuroradiol. 43:339–345. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Jensen JH, Helpern JA, Ramani A, Lu H and Kaczynski K: Diffusional kurtosis imaging: The quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 53:1432–1440. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Smith SM, Johansen-Berg H, Jenkinson M, Rueckert D, Nichols TE, Miller KL, Robson MD, Jones DK, Klein JC, Bartsch AJ and Behrens TE: Acquisition and voxelwise analysis of multi-subject diffusion data with tract-based spatial statistics. Nat Protoc. 2:499–503. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Guo YL, Li SJ, Zhang ZP, Shen ZW, Zhang GS, Yan G, Wang YT, Rao HB, Zheng WB and Wu RH: Parameters of diffusional kurtosis imaging for the diagnosis of acute cerebral infarction in different brain regions. Exp Ther Med. 12:933–938. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Kamiya K, Kamagata K, Miyajima M, Nakajima M, Hori M, Tsuruta K, Mori H, Kunimatsu A, Arai H, Aoki S and Ohtomo K: Diffusional kurtosis imaging in idiopathic normal pressure hydrocephalus: Correlation with severity of cognitive impairment. Magn Reson Med Sci. 15:316–323. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Lee CY, Tabesh A, Spampinato MV, Helpern JA, Jensen JH and Bonilha L: Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy. Acta Neurol Scand. 130:148–155. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Z, Liao W, Chen H, Mantini D, Ding JR, Xu Q, Wang Z, Yuan C, Chen G, Jiao Q and Lu G: Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain. 134:2912–2928. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Engel J Jr; International League Against Epilepsy (ILAE), : A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE task force on classification and terminology. Epilepsia. 42:796–803. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Chau W and McIntosh AR: The Talairach coordinate of a point in the MNI space: How to interpret it. NeuroImage. 25:408–416. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Li S, Tian J, Bauer A, Huang R, Wen H, Li M, Wang T, Xia L and Jiang G: Reduced integrity of right lateralized white matter in patients with primary insomnia: A diffusion-tensor imaging study. Radiology. 280:520–528. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Rohlfing T: Incorrect ICBM-DTI-81 atlas orientation and white matter labels. Front Neuroscience. 7:42013. View Article : Google Scholar

21 

Liao W, Zhang Z, Mantini D, Xu Q, Wang Z, Chen G, Jiao Q, Zang YF and Lu G: Relationship between large-scale functional and structural covariance networks in idiopathic generalized epilepsy. Brain Connect. 3:240–254. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zhu L, Li Y, Wang Y, Li R, Zhang Z, Lu G and Chen H: Aberrant long-range functional connectivity density in generalized tonic-clonic seizures. Medicine (Baltimore). 95:e38932016. View Article : Google Scholar : PubMed/NCBI

23 

Zhang CH, Sha Z, Mundahl J, Liu S, Lu Y, Henry TR and He B: Thalamocortical relationship in epileptic patients with generalized spike and wave discharges-a multimodal neuroimaging study. NeuroImage Clin. 9:117–127. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Zhong Y, Lu G, Zhang Z, Jiao Q, Li K and Liu Y: Altered regional synchronization in epileptic patients with generalized tonic-clonic seizures. Epilepsy Res. 97:83–91. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Paz JT, Davidson TJ, Frechette ES, Delord B, Parada I, Peng K, Deisseroth K and Huguenard JR: Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci. 16:64–70. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Huang W, Lu G, Zhang Z, Zhong Y, Wang Z, Yuan C, Jiao Q, Qian Z, Tan Q, Chen G, et al: Gray-matter volume reduction in the thalamus and frontal lobe in epileptic patients with generalized tonic-clonic seizures. J Neuroradiol. 38:298–303. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Luo C, Li Q, Xia Y, Lei X, Xue K, Yao Z, Lai Y, Martínez-Montes E, Liao W, Zhou D, et al: Resting state basal ganglia network in idiopathic generalized epilepsy. Hum Brain Mapp. 33:1279–1294. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Ciumas C and Savic I: Structural changes in patients with primary generalized tonic and clonic seizures. Neurology. 67:683–686. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Ciumas C, Wahlin TB, Espino C and Savic I: The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes. NeuroImage. 51:606–615. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Akman O, Gulcebi MI, Carcak N, Ketenci Ozatman S, Eryigit T, Moshé SL, Galanopoulou AS and Onat FY: The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy. Epilepsia. 56:1793–1802. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Robinson S, Basso G, Soldati N, Sailer U, Jovicich J, Bruzzone L, Kryspin-Exner I, Bauer H and Moser E: A resting state network in the motor control circuit of the basal ganglia. BMC Neurosci. 10:1372009. View Article : Google Scholar : PubMed/NCBI

32 

Zhang D, Snyder AZ, Fox MD, Sansbury MW, Shimony JS and Raichle ME: Intrinsic functional relations between human cerebral cortex and thalamus. J Neurophysiol. 100:1740–1748. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Rektor I, Kuba R, Brazdil M and Chrastina J: Do the basal ganglia inhibit seizure activity in temporal lobe epilepsy? Epilepsy Behav. 25:56–59. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Mohan A, Roberto AJ, Lorenzo A, Jones K, Carney MJ, Liogier-Weyback L, Hwang S and Lapidus KA: The significance of the default mode network (DMN) in neurological and neuropsychiatric disorders: A review. Yale J Biol Med. 89:49–57. 2016.PubMed/NCBI

35 

Menon V: Large-scale brain networks and psychopathology: A unifying triple network model. Trends Cogn Sci. 15:483–506. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Wei H, An J, Shen H, Zeng LL, Qiu S and Hu D: Altered effective connectivity among core neurocognitive networks in idiopathic generalized epilepsy: An fMRI evidence. Front Hum Neurosci. 10:4472016. View Article : Google Scholar : PubMed/NCBI

37 

Laureys S, Owen A and Schiff N: Coma science: Clinical and ethical implications. Preface. Prog Brain Res. 177:xiii–xiv. 2009.PubMed/NCBI

38 

Yoo NJ, Kim HR, Kim YR, An CH and Lee SH: Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology. 60:943–952. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Anastasopoulou S, Kurth F, Luders E and Savic I: Generalized epilepsy syndromes and callosal thickness: Differential effects between patients with juvenile myoclonic epilepsy and those with generalized tonic-clonic seizures alone. Epilepsy Res. 129:74–78. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Matsuo A, Ono T, Baba H and Ono K: Callosal role in generation of epileptiform discharges: Quantitative analysis of EEGs recorded in patients undergoing corpus callosotomy. Clin Neurophysiol. 114:2165–2171. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Jenssen S, Sperling MR, Tracy JI, Nei M, Joyce L, David G and O'Connor M: Corpus callosotomy in refractory idiopathic generalized epilepsy. Seizure. 15:621–629. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Lee CY, Bennett KM and Debbins JP: Sensitivities of statistical distribution model and diffusion kurtosis model in varying microstructural environments: A monte carlo study. J Magn Reson. 230:19–26. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Kamagata K, Tomiyama H, Hatano T, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Yoshida M, et al: A preliminary diffusional kurtosis imaging study of parkinson disease: Comparison with conventional diffusion tensor imaging. Neuroradiology. 56:251–258. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Gungor-Tuncer O, Baykan B, Altindag E, Bebek N, Gurses C and Gokyigit A: Prevalence and characteristics of visual aura in idiopathic generalized epilepsy. Epilepsy Behav. 25:573–576. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Sasson E, Doniger GM, Pasternak O, Tarrasch R and Assaf Y: White matter correlates of cognitive domains in normal aging with diffusion tensor imaging. Front Neurosci. 7:322013. View Article : Google Scholar : PubMed/NCBI

46 

Du H, Zhang Y, Xie B, Wu N, Wu G, Wang J, Jiang T and Feng H: Regional atrophy of the basal ganglia and thalamus in idiopathic generalized epilepsy. J Magn Reson Imaging. 33:817–821. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Walser G, Unterberger I, Dobesberger J, Embacher N, Falkenstetter T, Larch J, Kuchukhidze G, Gotwald T, Ortler M, Bauer G and Trinka E: Asymmetric seizure termination in primary and secondary generalized tonic-clonic seizures. Epilepsia. 50:2035–2039. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu G, Lyu G, Yang N, Chen B, Yang J, Hu Y, Lei Y, Xia J, Lin F, Fan G, Fan G, et al: Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures. Exp Ther Med 17: 603-612, 2019.
APA
Liu, G., Lyu, G., Yang, N., Chen, B., Yang, J., Hu, Y. ... Fan, G. (2019). Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures. Experimental and Therapeutic Medicine, 17, 603-612. https://doi.org/10.3892/etm.2018.7018
MLA
Liu, G., Lyu, G., Yang, N., Chen, B., Yang, J., Hu, Y., Lei, Y., Xia, J., Lin, F., Fan, G."Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures". Experimental and Therapeutic Medicine 17.1 (2019): 603-612.
Chicago
Liu, G., Lyu, G., Yang, N., Chen, B., Yang, J., Hu, Y., Lei, Y., Xia, J., Lin, F., Fan, G."Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures". Experimental and Therapeutic Medicine 17, no. 1 (2019): 603-612. https://doi.org/10.3892/etm.2018.7018
Copy and paste a formatted citation
x
Spandidos Publications style
Liu G, Lyu G, Yang N, Chen B, Yang J, Hu Y, Lei Y, Xia J, Lin F, Fan G, Fan G, et al: Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures. Exp Ther Med 17: 603-612, 2019.
APA
Liu, G., Lyu, G., Yang, N., Chen, B., Yang, J., Hu, Y. ... Fan, G. (2019). Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures. Experimental and Therapeutic Medicine, 17, 603-612. https://doi.org/10.3892/etm.2018.7018
MLA
Liu, G., Lyu, G., Yang, N., Chen, B., Yang, J., Hu, Y., Lei, Y., Xia, J., Lin, F., Fan, G."Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures". Experimental and Therapeutic Medicine 17.1 (2019): 603-612.
Chicago
Liu, G., Lyu, G., Yang, N., Chen, B., Yang, J., Hu, Y., Lei, Y., Xia, J., Lin, F., Fan, G."Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic‑clonic seizures". Experimental and Therapeutic Medicine 17, no. 1 (2019): 603-612. https://doi.org/10.3892/etm.2018.7018
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