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Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues

  • Authors:
    • Xinsheng Lin
    • Guofeng Wen
    • Shuangle Wang
    • Hangui Lu
    • Chuangwei Li
    • Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Shantou Central Hospital, Shantou, Guangdong 515031, P.R. China, Department of Otolaryngology‑Head and Neck Surgery, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 782-790
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    Published online on: November 28, 2018
       https://doi.org/10.3892/etm.2018.7027
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Abstract

Epidermal growth factor receptor (EGFR), cyclin D1 and KRAS proto‑oncogene, GTPase (KRAS) genes serve roles in the occurrence and development of tumors. The aim of the current study was to investigate the expression levels of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues and their association with clinical features. In addition, correlation between the expression levels of EGFR, cyclin D1 and KRAS was analyzed in laryngocarcinoma tissues. The expression levels of EGFR, cyclin D1 and KRAS in 46 patients with laryngocarcinoma and 20 patients with vocal cord polyps as the control group were determined using Super Vision immunohistochemical staining assay kits. The differences in clinical and pathological parameters between groups were statistically analyzed using SPSS software version 16.0. The expression rates of EGFR, cyclin D1 and KRAS were 71.7, 52.2 and 39.1%, respectively in laryngocarcinoma tissues, and 10.0, 5.0 and 10.0%, respectively in vocal cord polyps. There was a positive correlation between the expression levels of EGFR, cyclin D1 and KRAS. The expression of these genes was also closely associated with the clinical stage, treatment response and prognosis of patients with laryngocarcinoma. Multivariate analysis of prognosis using the Cox regression model indicated that EGFR expression in laryngocarcinoma tissues and the clinical stage of patients with laryngocarcinoma were closely associated with patient prognosis. The results of the current study indicated that EGFR, cyclin D1 and KRAS were synergistically involved in the occurrence and development of laryngocarcinoma, directly affecting the prognosis of patients. Additionally, high expression of EGFR, cyclin D1 and KRAS facilitated the invasion and metastasis of laryngocarcinoma cells. The expression of EGFR in laryngocarcinoma tissues and clinical stage were two independent risk factors affecting the prognosis of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Wen G, Wang S, Lu H, Li C and Wang X: Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues. Exp Ther Med 17: 782-790, 2019.
APA
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., & Wang, X. (2019). Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues. Experimental and Therapeutic Medicine, 17, 782-790. https://doi.org/10.3892/etm.2018.7027
MLA
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., Wang, X."Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues". Experimental and Therapeutic Medicine 17.1 (2019): 782-790.
Chicago
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., Wang, X."Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues". Experimental and Therapeutic Medicine 17, no. 1 (2019): 782-790. https://doi.org/10.3892/etm.2018.7027
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Wen G, Wang S, Lu H, Li C and Wang X: Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues. Exp Ther Med 17: 782-790, 2019.
APA
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., & Wang, X. (2019). Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues. Experimental and Therapeutic Medicine, 17, 782-790. https://doi.org/10.3892/etm.2018.7027
MLA
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., Wang, X."Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues". Experimental and Therapeutic Medicine 17.1 (2019): 782-790.
Chicago
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., Wang, X."Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues". Experimental and Therapeutic Medicine 17, no. 1 (2019): 782-790. https://doi.org/10.3892/etm.2018.7027
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