Open Access

Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues

  • Authors:
    • Xinsheng Lin
    • Guofeng Wen
    • Shuangle Wang
    • Hangui Lu
    • Chuangwei Li
    • Xin Wang
  • View Affiliations

  • Published online on: November 28, 2018     https://doi.org/10.3892/etm.2018.7027
  • Pages: 782-790
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epidermal growth factor receptor (EGFR), cyclin D1 and KRAS proto‑oncogene, GTPase (KRAS) genes serve roles in the occurrence and development of tumors. The aim of the current study was to investigate the expression levels of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues and their association with clinical features. In addition, correlation between the expression levels of EGFR, cyclin D1 and KRAS was analyzed in laryngocarcinoma tissues. The expression levels of EGFR, cyclin D1 and KRAS in 46 patients with laryngocarcinoma and 20 patients with vocal cord polyps as the control group were determined using Super Vision immunohistochemical staining assay kits. The differences in clinical and pathological parameters between groups were statistically analyzed using SPSS software version 16.0. The expression rates of EGFR, cyclin D1 and KRAS were 71.7, 52.2 and 39.1%, respectively in laryngocarcinoma tissues, and 10.0, 5.0 and 10.0%, respectively in vocal cord polyps. There was a positive correlation between the expression levels of EGFR, cyclin D1 and KRAS. The expression of these genes was also closely associated with the clinical stage, treatment response and prognosis of patients with laryngocarcinoma. Multivariate analysis of prognosis using the Cox regression model indicated that EGFR expression in laryngocarcinoma tissues and the clinical stage of patients with laryngocarcinoma were closely associated with patient prognosis. The results of the current study indicated that EGFR, cyclin D1 and KRAS were synergistically involved in the occurrence and development of laryngocarcinoma, directly affecting the prognosis of patients. Additionally, high expression of EGFR, cyclin D1 and KRAS facilitated the invasion and metastasis of laryngocarcinoma cells. The expression of EGFR in laryngocarcinoma tissues and clinical stage were two independent risk factors affecting the prognosis of patients.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lin X, Wen G, Wang S, Lu H, Li C and Wang X: Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues. Exp Ther Med 17: 782-790, 2019
APA
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., & Wang, X. (2019). Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues. Experimental and Therapeutic Medicine, 17, 782-790. https://doi.org/10.3892/etm.2018.7027
MLA
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., Wang, X."Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues". Experimental and Therapeutic Medicine 17.1 (2019): 782-790.
Chicago
Lin, X., Wen, G., Wang, S., Lu, H., Li, C., Wang, X."Expression and role of EGFR, cyclin D1 and KRAS in laryngocarcinoma tissues". Experimental and Therapeutic Medicine 17, no. 1 (2019): 782-790. https://doi.org/10.3892/etm.2018.7027